Plasma Level’s of Neuregulin-1 in Healthy People
Aim. To determine the median levels of neuregulin-1 (NRG-1; endothelium-derived growth factor and the natural agonist of the ERBB3 and ERBB4 receptors) NRG-1 in healthy volunteers and to study the associations of NRG-1 levels with gender and age.Material and Methods. Ninety seven healthy participant...
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| Format: | Article |
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Столичная издательская компания
2022-01-01
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| Series: | Рациональная фармакотерапия в кардиологии |
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| Online Access: | https://www.rpcardio.online/jour/article/view/2622 |
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| author | K. A. Zhbanov A. A. Shchendrygina E. A. Zheleznykh E. V. Privalova A. Y. Suvorov A. S. Ablyametova N. F. Fuksman E. Yu. Salakheeva Yu. N. Belenkov |
| author_facet | K. A. Zhbanov A. A. Shchendrygina E. A. Zheleznykh E. V. Privalova A. Y. Suvorov A. S. Ablyametova N. F. Fuksman E. Yu. Salakheeva Yu. N. Belenkov |
| author_sort | K. A. Zhbanov |
| collection | DOAJ |
| description | Aim. To determine the median levels of neuregulin-1 (NRG-1; endothelium-derived growth factor and the natural agonist of the ERBB3 and ERBB4 receptors) NRG-1 in healthy volunteers and to study the associations of NRG-1 levels with gender and age.Material and Methods. Ninety seven healthy participants were enrolled (median age of 44 [32-54], men 45 men [46.4%]). The following age groups were identified: 20-29 y.о. (n=20, men – 50.0%), 30-39 y.о. (n=21, men – 52.4%), 40-49 y.о. (n=22, men – 45.5%), 50-59 y.о. (n=22, men – 36.4%); 60-69 y.о. (n=12, men – 50.0%). Peripheral blood samples were collected at the time of enrolment, standard laboratory tests were performed, and NRG-1 levels were determined in the plasma samples by ELISA.Results. In the cohort of 97 healthy participants the median value of NRG-1 was 0.3 [0.121-2.24] ng/ml. NRG-1 levels did not differ significantly between men and women (p=0.145), indicating that NRG-1 levels are not influenced by gender. The levels of NRG-1 were similar in the different age groups: age 20-29 years=0.26 [0.17-0.37] ng/ml; age 30-39=0.24 [0.1-0.39] ng/ml; age 40-49=0.31 [0.19-1.15] ng/ml; age 50-59=0.37 [0.19-1.0] ng/ml; age 60-69=0.4 [0.13-0.81] ng/ml. Correlation analysis between NRG-1 levels and route blood measurements (haemoglobin, lipids, glucose, creatinine, and uretic acid) did not show significant associations.Conclusions. In this study, the median value of NRG-1 plasma levels were determined. The results of the study show that age and gender had no influence on NRG-1 values. |
| format | Article |
| id | doaj-art-0ce5df5ad42647ef804ef075ba009ed4 |
| institution | Kabale University |
| issn | 1819-6446 2225-3653 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj-art-0ce5df5ad42647ef804ef075ba009ed42025-08-23T10:00:34ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532022-01-0117685385910.20996/1819-6446-2021-11-011965Plasma Level’s of Neuregulin-1 in Healthy PeopleK. A. Zhbanov0A. A. Shchendrygina1E. A. Zheleznykh2E. V. Privalova3A. Y. Suvorov4A. S. Ablyametova5N. F. Fuksman6E. Yu. Salakheeva7Yu. N. Belenkov8I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)Aim. To determine the median levels of neuregulin-1 (NRG-1; endothelium-derived growth factor and the natural agonist of the ERBB3 and ERBB4 receptors) NRG-1 in healthy volunteers and to study the associations of NRG-1 levels with gender and age.Material and Methods. Ninety seven healthy participants were enrolled (median age of 44 [32-54], men 45 men [46.4%]). The following age groups were identified: 20-29 y.о. (n=20, men – 50.0%), 30-39 y.о. (n=21, men – 52.4%), 40-49 y.о. (n=22, men – 45.5%), 50-59 y.о. (n=22, men – 36.4%); 60-69 y.о. (n=12, men – 50.0%). Peripheral blood samples were collected at the time of enrolment, standard laboratory tests were performed, and NRG-1 levels were determined in the plasma samples by ELISA.Results. In the cohort of 97 healthy participants the median value of NRG-1 was 0.3 [0.121-2.24] ng/ml. NRG-1 levels did not differ significantly between men and women (p=0.145), indicating that NRG-1 levels are not influenced by gender. The levels of NRG-1 were similar in the different age groups: age 20-29 years=0.26 [0.17-0.37] ng/ml; age 30-39=0.24 [0.1-0.39] ng/ml; age 40-49=0.31 [0.19-1.15] ng/ml; age 50-59=0.37 [0.19-1.0] ng/ml; age 60-69=0.4 [0.13-0.81] ng/ml. Correlation analysis between NRG-1 levels and route blood measurements (haemoglobin, lipids, glucose, creatinine, and uretic acid) did not show significant associations.Conclusions. In this study, the median value of NRG-1 plasma levels were determined. The results of the study show that age and gender had no influence on NRG-1 values.https://www.rpcardio.online/jour/article/view/2622neuregulin-1nrg-1erbb3erbb4 |
| spellingShingle | K. A. Zhbanov A. A. Shchendrygina E. A. Zheleznykh E. V. Privalova A. Y. Suvorov A. S. Ablyametova N. F. Fuksman E. Yu. Salakheeva Yu. N. Belenkov Plasma Level’s of Neuregulin-1 in Healthy People Рациональная фармакотерапия в кардиологии neuregulin-1 nrg-1 erbb3 erbb4 |
| title | Plasma Level’s of Neuregulin-1 in Healthy People |
| title_full | Plasma Level’s of Neuregulin-1 in Healthy People |
| title_fullStr | Plasma Level’s of Neuregulin-1 in Healthy People |
| title_full_unstemmed | Plasma Level’s of Neuregulin-1 in Healthy People |
| title_short | Plasma Level’s of Neuregulin-1 in Healthy People |
| title_sort | plasma level s of neuregulin 1 in healthy people |
| topic | neuregulin-1 nrg-1 erbb3 erbb4 |
| url | https://www.rpcardio.online/jour/article/view/2622 |
| work_keys_str_mv | AT kazhbanov plasmalevelsofneuregulin1inhealthypeople AT aashchendrygina plasmalevelsofneuregulin1inhealthypeople AT eazheleznykh plasmalevelsofneuregulin1inhealthypeople AT evprivalova plasmalevelsofneuregulin1inhealthypeople AT aysuvorov plasmalevelsofneuregulin1inhealthypeople AT asablyametova plasmalevelsofneuregulin1inhealthypeople AT nffuksman plasmalevelsofneuregulin1inhealthypeople AT eyusalakheeva plasmalevelsofneuregulin1inhealthypeople AT yunbelenkov plasmalevelsofneuregulin1inhealthypeople |