COVID-19 in an Adult with Down Syndrome: Impact on Autoimmune Response
We here report a case of COVID-19 with effusion prior to the development of pneumonia in an adult with Down syndrome. Serositis due to rheumatic disease was initially suspected because of a high titer of serum autoantibodies and leukocytopenia; however, SARS-CoV-2 infection was confirmed by reverse...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Case Reports in Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2022/6128496 |
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| _version_ | 1850232963211460608 |
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| author | Hiroshi Kobayashi Mana Akiniwa Yoshiko Yamaguchi Yuji Hirai Akiko Aoki |
| author_facet | Hiroshi Kobayashi Mana Akiniwa Yoshiko Yamaguchi Yuji Hirai Akiko Aoki |
| author_sort | Hiroshi Kobayashi |
| collection | DOAJ |
| description | We here report a case of COVID-19 with effusion prior to the development of pneumonia in an adult with Down syndrome. Serositis due to rheumatic disease was initially suspected because of a high titer of serum autoantibodies and leukocytopenia; however, SARS-CoV-2 infection was confirmed by reverse transcription polymerase chain reaction on admission after previous negative tests. Several cases of COVID-19 have been associated with autoimmune responses along with some cases of COVID-19 with autoimmune manifestations. Furthermore, patients with Down syndrome have a higher mortality risk from COVID-19 than the general population, and it is believed that a high sensitivity to the interferon response may contribute to the increased severity of the disease. Thus, careful attention should be paid to autoimmune manifestations due to SARS-CoV-2 infection for ensuring a proper and timely diagnosis, especially in patients with Down syndrome. |
| format | Article |
| id | doaj-art-0ce558e8d91d47cbbe765f3e714f4ed0 |
| institution | OA Journals |
| issn | 2090-6633 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Infectious Diseases |
| spelling | doaj-art-0ce558e8d91d47cbbe765f3e714f4ed02025-08-20T02:03:01ZengWileyCase Reports in Infectious Diseases2090-66332022-01-01202210.1155/2022/6128496COVID-19 in an Adult with Down Syndrome: Impact on Autoimmune ResponseHiroshi Kobayashi0Mana Akiniwa1Yoshiko Yamaguchi2Yuji Hirai3Akiko Aoki4Department of RheumatologyDepartment of RheumatologyDepartment of General Medicine and Primary CareDepartment of Infectious DiseasesDepartment of RheumatologyWe here report a case of COVID-19 with effusion prior to the development of pneumonia in an adult with Down syndrome. Serositis due to rheumatic disease was initially suspected because of a high titer of serum autoantibodies and leukocytopenia; however, SARS-CoV-2 infection was confirmed by reverse transcription polymerase chain reaction on admission after previous negative tests. Several cases of COVID-19 have been associated with autoimmune responses along with some cases of COVID-19 with autoimmune manifestations. Furthermore, patients with Down syndrome have a higher mortality risk from COVID-19 than the general population, and it is believed that a high sensitivity to the interferon response may contribute to the increased severity of the disease. Thus, careful attention should be paid to autoimmune manifestations due to SARS-CoV-2 infection for ensuring a proper and timely diagnosis, especially in patients with Down syndrome.http://dx.doi.org/10.1155/2022/6128496 |
| spellingShingle | Hiroshi Kobayashi Mana Akiniwa Yoshiko Yamaguchi Yuji Hirai Akiko Aoki COVID-19 in an Adult with Down Syndrome: Impact on Autoimmune Response Case Reports in Infectious Diseases |
| title | COVID-19 in an Adult with Down Syndrome: Impact on Autoimmune Response |
| title_full | COVID-19 in an Adult with Down Syndrome: Impact on Autoimmune Response |
| title_fullStr | COVID-19 in an Adult with Down Syndrome: Impact on Autoimmune Response |
| title_full_unstemmed | COVID-19 in an Adult with Down Syndrome: Impact on Autoimmune Response |
| title_short | COVID-19 in an Adult with Down Syndrome: Impact on Autoimmune Response |
| title_sort | covid 19 in an adult with down syndrome impact on autoimmune response |
| url | http://dx.doi.org/10.1155/2022/6128496 |
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