Synthetic protocells interact with viral nanomachinery and inactivate pathogenic human virus.
We present a new antiviral strategy and research tool that could be applied to a wide range of enveloped viruses that infect human beings via membrane fusion. We test this strategy on two emerging zoonotic henipaviruses that cause fatal encephalitis in humans, Nipah (NiV) and Hendra (HeV) viruses. I...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2011-03-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0016874&type=printable |
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| author | Matteo Porotto Feng Yi Anne Moscona David A LaVan |
| author_facet | Matteo Porotto Feng Yi Anne Moscona David A LaVan |
| author_sort | Matteo Porotto |
| collection | DOAJ |
| description | We present a new antiviral strategy and research tool that could be applied to a wide range of enveloped viruses that infect human beings via membrane fusion. We test this strategy on two emerging zoonotic henipaviruses that cause fatal encephalitis in humans, Nipah (NiV) and Hendra (HeV) viruses. In the new approach, artificial cell-like particles (protocells) presenting membrane receptors in a biomimetic manner were developed and found to attract and inactivate henipavirus envelope glycoprotein pseudovirus particles, preventing infection. The protocells do not accumulate virus during the inactivation process. The use of protocells that interact with, but do not accumulate, viruses may provide significant advantages over current antiviral drugs, and this general approach may have wide potential for antiviral development. |
| format | Article |
| id | doaj-art-0ce33b43f717432b8d99e76b1da6570e |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2011-03-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-0ce33b43f717432b8d99e76b1da6570e2025-08-20T03:10:23ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-03-0163e1687410.1371/journal.pone.0016874Synthetic protocells interact with viral nanomachinery and inactivate pathogenic human virus.Matteo PorottoFeng YiAnne MosconaDavid A LaVanWe present a new antiviral strategy and research tool that could be applied to a wide range of enveloped viruses that infect human beings via membrane fusion. We test this strategy on two emerging zoonotic henipaviruses that cause fatal encephalitis in humans, Nipah (NiV) and Hendra (HeV) viruses. In the new approach, artificial cell-like particles (protocells) presenting membrane receptors in a biomimetic manner were developed and found to attract and inactivate henipavirus envelope glycoprotein pseudovirus particles, preventing infection. The protocells do not accumulate virus during the inactivation process. The use of protocells that interact with, but do not accumulate, viruses may provide significant advantages over current antiviral drugs, and this general approach may have wide potential for antiviral development.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0016874&type=printable |
| spellingShingle | Matteo Porotto Feng Yi Anne Moscona David A LaVan Synthetic protocells interact with viral nanomachinery and inactivate pathogenic human virus. PLoS ONE |
| title | Synthetic protocells interact with viral nanomachinery and inactivate pathogenic human virus. |
| title_full | Synthetic protocells interact with viral nanomachinery and inactivate pathogenic human virus. |
| title_fullStr | Synthetic protocells interact with viral nanomachinery and inactivate pathogenic human virus. |
| title_full_unstemmed | Synthetic protocells interact with viral nanomachinery and inactivate pathogenic human virus. |
| title_short | Synthetic protocells interact with viral nanomachinery and inactivate pathogenic human virus. |
| title_sort | synthetic protocells interact with viral nanomachinery and inactivate pathogenic human virus |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0016874&type=printable |
| work_keys_str_mv | AT matteoporotto syntheticprotocellsinteractwithviralnanomachineryandinactivatepathogenichumanvirus AT fengyi syntheticprotocellsinteractwithviralnanomachineryandinactivatepathogenichumanvirus AT annemoscona syntheticprotocellsinteractwithviralnanomachineryandinactivatepathogenichumanvirus AT davidalavan syntheticprotocellsinteractwithviralnanomachineryandinactivatepathogenichumanvirus |