Personalized neoadjuvant strategy using 70-gene assay to increase breast-conserving surgery in ER+/HER2– breast cancer

Personalized neoadjuvant strategy using 70-gene assay to increase breast-conserving surgery in ER+/HER2– breast cancer

Abstract We investigated whether tailored neoadjuvant therapy (chemotherapy [NCT] or endocrine therapy [NET]) guided by a 70-gene assay could improve breast-conserving surgery (BCS) rates among patients with ER-positive/HER2-negative breast cancer initially deemed ineligible for BCS. Of 130 prospect...

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Main Authors: Wonshik Han, Eunhye Kang, Ji Gwang Jung, Hong-Kyu Kim, Han-Byoel Lee, Jisun Kim, Sae Byul Lee, Hee-Chul Shin, Chan Sub Park, Min-Ki Seong, Hyun-Ah Kim, Eun-Kyu Kim, Byung Ho Son
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:npj Breast Cancer
Online Access:https://doi.org/10.1038/s41523-025-00772-5
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