A Tale of Two Hematological Malignancies: CML Followed by CLL in the Same Patient
Studies have reported second malignancies occurring in patients with chronic myeloid leukemia (CML) or chronic lymphoid leukemia (CLL). We discuss the case of a 77-year-old man diagnosed with CLL who later developed CML. The CLL was managed with surveillance after diagnosis for 3 years and later tre...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
American College of Physicians
2023-01-01
|
| Series: | Annals of Internal Medicine: Clinical Cases |
| Online Access: | https://www.acpjournals.org/doi/10.7326/aimcc.2022.0116 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850202531086467072 |
|---|---|
| author | Insija Selene Aasems Jacob Zain Mary El-Amir Sanjivani Sathe Asma Taj |
| author_facet | Insija Selene Aasems Jacob Zain Mary El-Amir Sanjivani Sathe Asma Taj |
| author_sort | Insija Selene |
| collection | DOAJ |
| description | Studies have reported second malignancies occurring in patients with chronic myeloid leukemia (CML) or chronic lymphoid leukemia (CLL). We discuss the case of a 77-year-old man diagnosed with CLL who later developed CML. The CLL was managed with surveillance after diagnosis for 3 years and later treated with ibrutinib and venetoclax. While on treatment with venetoclax for 4 months, the patient had worsening leukocytosis shown via peripheral flow cytometry and fluorescence in situ hybridization, with the presence of myeloid lineage cells positive for BCR-ABL and complete disappearance of lymphoid cells. This case report highlights the importance of considering a second malignancy in hematologic malignancies with variable disease prognosis. |
| format | Article |
| id | doaj-art-0ce27936852b42399a4d24a3e6d4d00d |
| institution | OA Journals |
| issn | 2767-7664 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | American College of Physicians |
| record_format | Article |
| series | Annals of Internal Medicine: Clinical Cases |
| spelling | doaj-art-0ce27936852b42399a4d24a3e6d4d00d2025-08-20T02:11:46ZengAmerican College of PhysiciansAnnals of Internal Medicine: Clinical Cases2767-76642023-01-012110.7326/aimcc.2022.0116A Tale of Two Hematological Malignancies: CML Followed by CLL in the Same PatientInsija Selene0Aasems Jacob1Zain Mary El-Amir2Sanjivani Sathe3Asma Taj41Division of Hematology Oncology, University of Kentucky, Kentucky2Division of Internal Medicine, Pikeville Medical Center, Pikeville, Kentucky1Division of Hematology Oncology, University of Kentucky, Kentucky3Division of Internal Medicine, Carle Foundation Hospital, Urbana, Illinois4Division of Hematology & Oncology, Ascension Medical Group, Saginaw, MichiganStudies have reported second malignancies occurring in patients with chronic myeloid leukemia (CML) or chronic lymphoid leukemia (CLL). We discuss the case of a 77-year-old man diagnosed with CLL who later developed CML. The CLL was managed with surveillance after diagnosis for 3 years and later treated with ibrutinib and venetoclax. While on treatment with venetoclax for 4 months, the patient had worsening leukocytosis shown via peripheral flow cytometry and fluorescence in situ hybridization, with the presence of myeloid lineage cells positive for BCR-ABL and complete disappearance of lymphoid cells. This case report highlights the importance of considering a second malignancy in hematologic malignancies with variable disease prognosis.https://www.acpjournals.org/doi/10.7326/aimcc.2022.0116 |
| spellingShingle | Insija Selene Aasems Jacob Zain Mary El-Amir Sanjivani Sathe Asma Taj A Tale of Two Hematological Malignancies: CML Followed by CLL in the Same Patient Annals of Internal Medicine: Clinical Cases |
| title | A Tale of Two Hematological Malignancies: CML Followed by CLL in the Same Patient |
| title_full | A Tale of Two Hematological Malignancies: CML Followed by CLL in the Same Patient |
| title_fullStr | A Tale of Two Hematological Malignancies: CML Followed by CLL in the Same Patient |
| title_full_unstemmed | A Tale of Two Hematological Malignancies: CML Followed by CLL in the Same Patient |
| title_short | A Tale of Two Hematological Malignancies: CML Followed by CLL in the Same Patient |
| title_sort | tale of two hematological malignancies cml followed by cll in the same patient |
| url | https://www.acpjournals.org/doi/10.7326/aimcc.2022.0116 |
| work_keys_str_mv | AT insijaselene ataleoftwohematologicalmalignanciescmlfollowedbycllinthesamepatient AT aasemsjacob ataleoftwohematologicalmalignanciescmlfollowedbycllinthesamepatient AT zainmaryelamir ataleoftwohematologicalmalignanciescmlfollowedbycllinthesamepatient AT sanjivanisathe ataleoftwohematologicalmalignanciescmlfollowedbycllinthesamepatient AT asmataj ataleoftwohematologicalmalignanciescmlfollowedbycllinthesamepatient AT insijaselene taleoftwohematologicalmalignanciescmlfollowedbycllinthesamepatient AT aasemsjacob taleoftwohematologicalmalignanciescmlfollowedbycllinthesamepatient AT zainmaryelamir taleoftwohematologicalmalignanciescmlfollowedbycllinthesamepatient AT sanjivanisathe taleoftwohematologicalmalignanciescmlfollowedbycllinthesamepatient AT asmataj taleoftwohematologicalmalignanciescmlfollowedbycllinthesamepatient |