The Role of Complement System in Septic Shock
Septic shock is a critical clinical condition with a high mortality rate. A better understanding of the underlying mechanisms is important to develop effective therapies. Basic and clinical studies suggest that activation of complements in the common cascade, for example, complement component 3 (C3)...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/407324 |
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| author | Jean Charchaflieh Jiandong Wei Georges Labaze Yunfang Joan Hou Benjamin Babarsh Helen Stutz Haekyung Lee Samrat Worah Ming Zhang |
| author_facet | Jean Charchaflieh Jiandong Wei Georges Labaze Yunfang Joan Hou Benjamin Babarsh Helen Stutz Haekyung Lee Samrat Worah Ming Zhang |
| author_sort | Jean Charchaflieh |
| collection | DOAJ |
| description | Septic shock is a critical clinical condition with a high mortality rate. A better understanding of the underlying mechanisms is important to develop effective therapies. Basic and clinical studies suggest that activation of complements in the common cascade, for example, complement component 3 (C3) and C5, is involved in the development of septic shock. The involvement of three upstream complement pathways in septic shock is more complicated. Both the classical and alternative pathways appear to be activated in septic shock, but the alternative pathway may be activated earlier than the classical pathway. Activation of these two pathways is essential to clear endotoxin. Recent investigations have shed light on the role of lectin complement pathway in septic shock. Published reports suggest a protective role of mannose-binding lectin (MBL) against sepsis. Our preliminary study of MBL-associated serine protease-2 (MASP-2) in septic shock patients indicated that acute decrease of MASP-2 in the early phase of septic shock might correlate with in-hospital mortality. It is unknown whether excessive activation of these three upstream complement pathways may contribute to the detrimental effects in septic shock. This paper also discusses additional complement-related pathogenic mechanisms and intervention strategies for septic shock. |
| format | Article |
| id | doaj-art-0ce1ddb4d2164752abfdfa5a2976a9c6 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-0ce1ddb4d2164752abfdfa5a2976a9c62025-02-03T06:13:10ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/407324407324The Role of Complement System in Septic ShockJean Charchaflieh0Jiandong Wei1Georges Labaze2Yunfang Joan Hou3Benjamin Babarsh4Helen Stutz5Haekyung Lee6Samrat Worah7Ming Zhang8Department of Anesthesiology, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USADepartment of Anesthesiology, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USADepartment of Anesthesiology, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USADepartment of Anesthesiology, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USADepartment of Anesthesiology, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USADepartment of Anesthesiology, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USADepartment of Anesthesiology, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USADepartment of Anesthesiology, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USADepartment of Anesthesiology, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USASeptic shock is a critical clinical condition with a high mortality rate. A better understanding of the underlying mechanisms is important to develop effective therapies. Basic and clinical studies suggest that activation of complements in the common cascade, for example, complement component 3 (C3) and C5, is involved in the development of septic shock. The involvement of three upstream complement pathways in septic shock is more complicated. Both the classical and alternative pathways appear to be activated in septic shock, but the alternative pathway may be activated earlier than the classical pathway. Activation of these two pathways is essential to clear endotoxin. Recent investigations have shed light on the role of lectin complement pathway in septic shock. Published reports suggest a protective role of mannose-binding lectin (MBL) against sepsis. Our preliminary study of MBL-associated serine protease-2 (MASP-2) in septic shock patients indicated that acute decrease of MASP-2 in the early phase of septic shock might correlate with in-hospital mortality. It is unknown whether excessive activation of these three upstream complement pathways may contribute to the detrimental effects in septic shock. This paper also discusses additional complement-related pathogenic mechanisms and intervention strategies for septic shock.http://dx.doi.org/10.1155/2012/407324 |
| spellingShingle | Jean Charchaflieh Jiandong Wei Georges Labaze Yunfang Joan Hou Benjamin Babarsh Helen Stutz Haekyung Lee Samrat Worah Ming Zhang The Role of Complement System in Septic Shock Clinical and Developmental Immunology |
| title | The Role of Complement System in Septic Shock |
| title_full | The Role of Complement System in Septic Shock |
| title_fullStr | The Role of Complement System in Septic Shock |
| title_full_unstemmed | The Role of Complement System in Septic Shock |
| title_short | The Role of Complement System in Septic Shock |
| title_sort | role of complement system in septic shock |
| url | http://dx.doi.org/10.1155/2012/407324 |
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