Advanced maternal age is a risk factor for both early and late gestational diabetes mellitus: The Japan Environment and Children's Study
ABSTRACT Aims This study investigated the association between maternal age and early and late gestational diabetes mellitus (GDM). Methods In total, 72,270 pregnant women were included in this prospective birth cohort study. Associations between maternal age and early GDM (diagnosed at <24 gestat...
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| Format: | Article |
| Language: | English |
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Wiley
2025-04-01
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| Series: | Journal of Diabetes Investigation |
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| Online Access: | https://doi.org/10.1111/jdi.14400 |
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| author | Kazuma Tagami Noriyuki Iwama Hirotaka Hamada Hasumi Tomita Rie Kudo Natsumi Kumagai Hongxin Wang Seiya Izumi Zen Watanabe Mami Ishikuro Taku Obara Hirohito Metoki Yuichiro Miura Chiharu Ota Takashi Sugiyama Shinichi Kuriyama Takahiro Arima Nobuo Yaegashi Masatoshi Saito The Japan Environment and Children's Study Group |
| author_facet | Kazuma Tagami Noriyuki Iwama Hirotaka Hamada Hasumi Tomita Rie Kudo Natsumi Kumagai Hongxin Wang Seiya Izumi Zen Watanabe Mami Ishikuro Taku Obara Hirohito Metoki Yuichiro Miura Chiharu Ota Takashi Sugiyama Shinichi Kuriyama Takahiro Arima Nobuo Yaegashi Masatoshi Saito The Japan Environment and Children's Study Group |
| author_sort | Kazuma Tagami |
| collection | DOAJ |
| description | ABSTRACT Aims This study investigated the association between maternal age and early and late gestational diabetes mellitus (GDM). Methods In total, 72,270 pregnant women were included in this prospective birth cohort study. Associations between maternal age and early GDM (diagnosed at <24 gestational weeks) and late GDM (diagnosed at ≥24 gestational weeks) were evaluated using a multinomial logistic regression model with possible confounding factors. The reference category was maternal age of 30–34.9 years. Results Higher maternal age was associated with higher odds of early and late GDM (P‐value for trend <0.0001 and <0.0001, respectively). The adjusted odds ratios (aORs) for early GDM with maternal age of 35–39.9 years and ≥40 were 1.399 (95% confidence interval [CI]: 1.134–1.725) and 2.494 (95% CI: 1.828–3.402), respectively. The aORs for late GDM with maternal age of 35–39 years and ≥40 were 1.603 (95% CI: 1.384–1.857) and 2.276 (95% CI: 1.798–2.881), respectively. Conclusions Higher maternal age was associated with an increased risk of GDM regardless of when GDM was diagnosed. The association between maternal age and early GDM was similar to that between maternal age and late GDM. |
| format | Article |
| id | doaj-art-0ce0bfa2db77497593d81b8441809e50 |
| institution | OA Journals |
| issn | 2040-1116 2040-1124 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Investigation |
| spelling | doaj-art-0ce0bfa2db77497593d81b8441809e502025-08-20T02:25:12ZengWileyJournal of Diabetes Investigation2040-11162040-11242025-04-0116473574310.1111/jdi.14400Advanced maternal age is a risk factor for both early and late gestational diabetes mellitus: The Japan Environment and Children's StudyKazuma Tagami0Noriyuki Iwama1Hirotaka Hamada2Hasumi Tomita3Rie Kudo4Natsumi Kumagai5Hongxin Wang6Seiya Izumi7Zen Watanabe8Mami Ishikuro9Taku Obara10Hirohito Metoki11Yuichiro Miura12Chiharu Ota13Takashi Sugiyama14Shinichi Kuriyama15Takahiro Arima16Nobuo Yaegashi17Masatoshi Saito18The Japan Environment and Children's Study GroupDepartment of Obstetrics and Gynecology Tohoku University Graduate School of Medicine Sendai Miyagi JapanDepartment of Obstetrics and Gynecology Tohoku University Graduate School of Medicine Sendai Miyagi JapanDepartment of Obstetrics and Gynecology Tohoku University Graduate School of Medicine Sendai Miyagi JapanDepartment of Obstetrics and Gynecology Tohoku University Graduate School of Medicine Sendai Miyagi JapanDepartment of Obstetrics and Gynecology Tohoku University Graduate School of Medicine Sendai Miyagi JapanDepartment of Obstetrics and Gynecology Tohoku University Graduate School of Medicine Sendai Miyagi JapanDepartment of Obstetrics and Gynecology Tohoku University Graduate School of Medicine Sendai Miyagi JapanDepartment of Obstetrics and Gynecology Tohoku University Graduate School of Medicine Sendai Miyagi JapanDepartment of Obstetrics and Gynecology Tohoku University Graduate School of Medicine Sendai Miyagi JapanDivision of Molecular Epidemiology, Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization Tohoku University Sendai Miyagi JapanDivision of Molecular Epidemiology, Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization Tohoku University Sendai Miyagi JapanDivision of Public Health, Hygiene and Epidemiology Tohoku Medical Pharmaceutical University Sendai Miyagi JapanEnvironment and Genome Research Center Tohoku University Graduate School of Medicine Sendai Miyagi JapanEnvironment and Genome Research Center Tohoku University Graduate School of Medicine Sendai Miyagi JapanDepartment of Obstetrics and Gynecology Ehime University Graduate School of Medicine Toon Ehime JapanDivision of Molecular Epidemiology, Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization Tohoku University Sendai Miyagi JapanEnvironment and Genome Research Center Tohoku University Graduate School of Medicine Sendai Miyagi JapanEnvironment and Genome Research Center Tohoku University Graduate School of Medicine Sendai Miyagi JapanDepartment of Obstetrics and Gynecology Tohoku University Graduate School of Medicine Sendai Miyagi JapanABSTRACT Aims This study investigated the association between maternal age and early and late gestational diabetes mellitus (GDM). Methods In total, 72,270 pregnant women were included in this prospective birth cohort study. Associations between maternal age and early GDM (diagnosed at <24 gestational weeks) and late GDM (diagnosed at ≥24 gestational weeks) were evaluated using a multinomial logistic regression model with possible confounding factors. The reference category was maternal age of 30–34.9 years. Results Higher maternal age was associated with higher odds of early and late GDM (P‐value for trend <0.0001 and <0.0001, respectively). The adjusted odds ratios (aORs) for early GDM with maternal age of 35–39.9 years and ≥40 were 1.399 (95% confidence interval [CI]: 1.134–1.725) and 2.494 (95% CI: 1.828–3.402), respectively. The aORs for late GDM with maternal age of 35–39 years and ≥40 were 1.603 (95% CI: 1.384–1.857) and 2.276 (95% CI: 1.798–2.881), respectively. Conclusions Higher maternal age was associated with an increased risk of GDM regardless of when GDM was diagnosed. The association between maternal age and early GDM was similar to that between maternal age and late GDM.https://doi.org/10.1111/jdi.14400Advanced maternal ageGestational diabetesInsulin resistance |
| spellingShingle | Kazuma Tagami Noriyuki Iwama Hirotaka Hamada Hasumi Tomita Rie Kudo Natsumi Kumagai Hongxin Wang Seiya Izumi Zen Watanabe Mami Ishikuro Taku Obara Hirohito Metoki Yuichiro Miura Chiharu Ota Takashi Sugiyama Shinichi Kuriyama Takahiro Arima Nobuo Yaegashi Masatoshi Saito The Japan Environment and Children's Study Group Advanced maternal age is a risk factor for both early and late gestational diabetes mellitus: The Japan Environment and Children's Study Journal of Diabetes Investigation Advanced maternal age Gestational diabetes Insulin resistance |
| title | Advanced maternal age is a risk factor for both early and late gestational diabetes mellitus: The Japan Environment and Children's Study |
| title_full | Advanced maternal age is a risk factor for both early and late gestational diabetes mellitus: The Japan Environment and Children's Study |
| title_fullStr | Advanced maternal age is a risk factor for both early and late gestational diabetes mellitus: The Japan Environment and Children's Study |
| title_full_unstemmed | Advanced maternal age is a risk factor for both early and late gestational diabetes mellitus: The Japan Environment and Children's Study |
| title_short | Advanced maternal age is a risk factor for both early and late gestational diabetes mellitus: The Japan Environment and Children's Study |
| title_sort | advanced maternal age is a risk factor for both early and late gestational diabetes mellitus the japan environment and children s study |
| topic | Advanced maternal age Gestational diabetes Insulin resistance |
| url | https://doi.org/10.1111/jdi.14400 |
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