Association between white blood cell counts and the efficacy on cognitive function after rTMS intervention in schizophrenia
Abstract rTMS has shown some effect in improving cognitive functions in patients with schizophrenia. However, these findings were controversial, and specific mechanisms of action and optimal therapeutic parameters still require further investigation. This study aimed to examine predictive biomarkers...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-03-01
|
| Series: | Schizophrenia |
| Online Access: | https://doi.org/10.1038/s41537-025-00590-5 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850039618759557120 |
|---|---|
| author | Suzhen Ye Bailing Wang Heling Sui Meihong Xiu Fengchun Wu |
| author_facet | Suzhen Ye Bailing Wang Heling Sui Meihong Xiu Fengchun Wu |
| author_sort | Suzhen Ye |
| collection | DOAJ |
| description | Abstract rTMS has shown some effect in improving cognitive functions in patients with schizophrenia. However, these findings were controversial, and specific mechanisms of action and optimal therapeutic parameters still require further investigation. This study aimed to examine predictive biomarkers of the efficacy of rTMS in cognitive improvement in schizophrenia. A secondary analysis of a previous randomized, controlled trial was performed. Fifty-six patients were allocated to the active rTMS and 28 to the sham group. Patients received 6 weeks of treatment and were followed up for 18 weeks. Cognition was assessed and blood biomarkers were measured in all patients. In patients with schizophrenia, there was a significant interaction between time and group on immediate memory. Furthermore, this study found that after controlling for confounders, patients with higher baseline white blood cell (WBC) counts showed less improvement in immediate memory after rTMS than patients with lower WBC counts. Linear regression analysis showed that WBC counts were associated with immediate memory improvement after rTMS treatment. Our results reveal that WBC counts at baseline correlated with the response to rTMS in patients with schizophrenia. Patients with higher baseline WBC counts improved less after rTMS intervention than those with lower WBC counts. |
| format | Article |
| id | doaj-art-0ce042f922a145fbb99acdad2b87b2b5 |
| institution | DOAJ |
| issn | 2754-6993 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Schizophrenia |
| spelling | doaj-art-0ce042f922a145fbb99acdad2b87b2b52025-08-20T02:56:16ZengNature PortfolioSchizophrenia2754-69932025-03-011111810.1038/s41537-025-00590-5Association between white blood cell counts and the efficacy on cognitive function after rTMS intervention in schizophreniaSuzhen Ye0Bailing Wang1Heling Sui2Meihong Xiu3Fengchun Wu4Department of Rehabilitation, The First Affiliated Hospital of Wenzhou Medical UniversityQingdao Mental Health CenterQingdao Mental Health CenterPeking University HuiLongGuan Clinical Medical School, Beijing HuiLongGuan HospitalDepartment of Psychiatry, The Affiliated Brain Hospital, Guangzhou Medical UniversityAbstract rTMS has shown some effect in improving cognitive functions in patients with schizophrenia. However, these findings were controversial, and specific mechanisms of action and optimal therapeutic parameters still require further investigation. This study aimed to examine predictive biomarkers of the efficacy of rTMS in cognitive improvement in schizophrenia. A secondary analysis of a previous randomized, controlled trial was performed. Fifty-six patients were allocated to the active rTMS and 28 to the sham group. Patients received 6 weeks of treatment and were followed up for 18 weeks. Cognition was assessed and blood biomarkers were measured in all patients. In patients with schizophrenia, there was a significant interaction between time and group on immediate memory. Furthermore, this study found that after controlling for confounders, patients with higher baseline white blood cell (WBC) counts showed less improvement in immediate memory after rTMS than patients with lower WBC counts. Linear regression analysis showed that WBC counts were associated with immediate memory improvement after rTMS treatment. Our results reveal that WBC counts at baseline correlated with the response to rTMS in patients with schizophrenia. Patients with higher baseline WBC counts improved less after rTMS intervention than those with lower WBC counts.https://doi.org/10.1038/s41537-025-00590-5 |
| spellingShingle | Suzhen Ye Bailing Wang Heling Sui Meihong Xiu Fengchun Wu Association between white blood cell counts and the efficacy on cognitive function after rTMS intervention in schizophrenia Schizophrenia |
| title | Association between white blood cell counts and the efficacy on cognitive function after rTMS intervention in schizophrenia |
| title_full | Association between white blood cell counts and the efficacy on cognitive function after rTMS intervention in schizophrenia |
| title_fullStr | Association between white blood cell counts and the efficacy on cognitive function after rTMS intervention in schizophrenia |
| title_full_unstemmed | Association between white blood cell counts and the efficacy on cognitive function after rTMS intervention in schizophrenia |
| title_short | Association between white blood cell counts and the efficacy on cognitive function after rTMS intervention in schizophrenia |
| title_sort | association between white blood cell counts and the efficacy on cognitive function after rtms intervention in schizophrenia |
| url | https://doi.org/10.1038/s41537-025-00590-5 |
| work_keys_str_mv | AT suzhenye associationbetweenwhitebloodcellcountsandtheefficacyoncognitivefunctionafterrtmsinterventioninschizophrenia AT bailingwang associationbetweenwhitebloodcellcountsandtheefficacyoncognitivefunctionafterrtmsinterventioninschizophrenia AT helingsui associationbetweenwhitebloodcellcountsandtheefficacyoncognitivefunctionafterrtmsinterventioninschizophrenia AT meihongxiu associationbetweenwhitebloodcellcountsandtheefficacyoncognitivefunctionafterrtmsinterventioninschizophrenia AT fengchunwu associationbetweenwhitebloodcellcountsandtheefficacyoncognitivefunctionafterrtmsinterventioninschizophrenia |