Pharmacokinetic Interactions between Cardiovascular Medicines and Plant Products
The growing use of plant products among patients with cardiovascular pharmacotherapy raises the concerns about their potential interactions with conventional cardiovascular medicines. Plant products can influence pharmacokinetics or/and pharmacological activity of coadministered drugs and some of th...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
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| Series: | Cardiovascular Therapeutics |
| Online Access: | http://dx.doi.org/10.1155/2019/9402781 |
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| _version_ | 1832550252137152512 |
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| author | Irina-Iuliana Costache Anca Miron Monica Hăncianu Viviana Aursulesei Alexandru Dan Costache Ana Clara Aprotosoaie |
| author_facet | Irina-Iuliana Costache Anca Miron Monica Hăncianu Viviana Aursulesei Alexandru Dan Costache Ana Clara Aprotosoaie |
| author_sort | Irina-Iuliana Costache |
| collection | DOAJ |
| description | The growing use of plant products among patients with cardiovascular pharmacotherapy raises the concerns about their potential interactions with conventional cardiovascular medicines. Plant products can influence pharmacokinetics or/and pharmacological activity of coadministered drugs and some of these interactions may lead to unexpected clinical outcomes. Numerous studies and case reports showed various pharmacokinetic interactions that are characterized by a high degree of unpredictability. This review highlights the pharmacokinetic clinically relevant interactions between major conventional cardiovascular medicines and plant products with an emphasis on their putative mechanisms, drawbacks of herbal products use, and the perspectives for further well-designed studies. |
| format | Article |
| id | doaj-art-0cdfc864746348648f64b17229f9fe0a |
| institution | Kabale University |
| issn | 1755-5914 1755-5922 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiovascular Therapeutics |
| spelling | doaj-art-0cdfc864746348648f64b17229f9fe0a2025-02-03T06:07:13ZengWileyCardiovascular Therapeutics1755-59141755-59222019-01-01201910.1155/2019/94027819402781Pharmacokinetic Interactions between Cardiovascular Medicines and Plant ProductsIrina-Iuliana Costache0Anca Miron1Monica Hăncianu2Viviana Aursulesei3Alexandru Dan Costache4Ana Clara Aprotosoaie5Faculty of Medicine, Grigore T.Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, RomaniaFaculty of Pharmacy, Grigore T.Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, RomaniaFaculty of Pharmacy, Grigore T.Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, RomaniaFaculty of Medicine, Grigore T.Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, RomaniaFaculty of Medicine, Grigore T.Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, RomaniaFaculty of Pharmacy, Grigore T.Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, RomaniaThe growing use of plant products among patients with cardiovascular pharmacotherapy raises the concerns about their potential interactions with conventional cardiovascular medicines. Plant products can influence pharmacokinetics or/and pharmacological activity of coadministered drugs and some of these interactions may lead to unexpected clinical outcomes. Numerous studies and case reports showed various pharmacokinetic interactions that are characterized by a high degree of unpredictability. This review highlights the pharmacokinetic clinically relevant interactions between major conventional cardiovascular medicines and plant products with an emphasis on their putative mechanisms, drawbacks of herbal products use, and the perspectives for further well-designed studies.http://dx.doi.org/10.1155/2019/9402781 |
| spellingShingle | Irina-Iuliana Costache Anca Miron Monica Hăncianu Viviana Aursulesei Alexandru Dan Costache Ana Clara Aprotosoaie Pharmacokinetic Interactions between Cardiovascular Medicines and Plant Products Cardiovascular Therapeutics |
| title | Pharmacokinetic Interactions between Cardiovascular Medicines and Plant Products |
| title_full | Pharmacokinetic Interactions between Cardiovascular Medicines and Plant Products |
| title_fullStr | Pharmacokinetic Interactions between Cardiovascular Medicines and Plant Products |
| title_full_unstemmed | Pharmacokinetic Interactions between Cardiovascular Medicines and Plant Products |
| title_short | Pharmacokinetic Interactions between Cardiovascular Medicines and Plant Products |
| title_sort | pharmacokinetic interactions between cardiovascular medicines and plant products |
| url | http://dx.doi.org/10.1155/2019/9402781 |
| work_keys_str_mv | AT irinaiulianacostache pharmacokineticinteractionsbetweencardiovascularmedicinesandplantproducts AT ancamiron pharmacokineticinteractionsbetweencardiovascularmedicinesandplantproducts AT monicahancianu pharmacokineticinteractionsbetweencardiovascularmedicinesandplantproducts AT vivianaaursulesei pharmacokineticinteractionsbetweencardiovascularmedicinesandplantproducts AT alexandrudancostache pharmacokineticinteractionsbetweencardiovascularmedicinesandplantproducts AT anaclaraaprotosoaie pharmacokineticinteractionsbetweencardiovascularmedicinesandplantproducts |