Cobalt Single‐Atom Intercalation in Molybdenum Disulfide Enhances Piezocatalytic and Enzyodynamic Activities for Advanced Cancer Therapeutics
Abstract Piezoelectric semiconductor nanomaterials have attracted considerable interest in piezocatalytic tumor treatment. However, piezocatalytic therapy encounters obstacles such as suboptimal piezoelectric responses, rapid electron‐hole recombination, inefficient energy harvesting, and the comple...
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2025-04-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202415485 |
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| author | Haomiao Bai Sujun Ding Yanfei Dai Jiefu Liu Huangjing Chen Wei Feng Dehong Yu Yu Chen Xuejun Ni |
| author_facet | Haomiao Bai Sujun Ding Yanfei Dai Jiefu Liu Huangjing Chen Wei Feng Dehong Yu Yu Chen Xuejun Ni |
| author_sort | Haomiao Bai |
| collection | DOAJ |
| description | Abstract Piezoelectric semiconductor nanomaterials have attracted considerable interest in piezocatalytic tumor treatment. However, piezocatalytic therapy encounters obstacles such as suboptimal piezoelectric responses, rapid electron‐hole recombination, inefficient energy harvesting, and the complexities of the tumor microenvironment. In this study, sulfur vacancy‐engineered cobalt (Co) single‐atom doped molybdenum disulfide (SA‐Co@MoS2) nanoflowers are strategically designed, which exhibit enhanced piezoelectric effects. Specifically, the introduction of Co single atom not only induces lattice distortion and out‐of‐plane polarization but also leads to the formation of numerous sulfur vacancies. These changes collectively narrow the intrinsic bandgap of the material, facilitating effective separation and migration of charge carriers, and enabling efficient production of reactive oxygen species under ultrasound stimulation. Additionally, the SA‐Co@MoS2 nanoflowers demonstrate improved enzymatic activity and exhibit glutathione depletion capabilities attributed to the mixed valence states of Co, intensifying oxidative stress in tumor cells, and leading to cell cycle arrest and apoptosis, while the inactivation of glutathione peroxidase 4 induces ferroptosis. Both in vitro and in vivo results indicate that SA‐Co@MoS2 nanoflowers can significantly eliminate tumor cells. This study offers valuable insights into the exploration of single‐atom doping‐enhanced piezoelectric sonosensitizers for cancer treatment, potentially paving the way for advancements in the field of piezocatalytic synergistic enzyodynamic therapy. |
| format | Article |
| id | doaj-art-0cdc824dff4346278688f86d3dbfbdce |
| institution | DOAJ |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-0cdc824dff4346278688f86d3dbfbdce2025-08-20T03:09:08ZengWileyAdvanced Science2198-38442025-04-011214n/an/a10.1002/advs.202415485Cobalt Single‐Atom Intercalation in Molybdenum Disulfide Enhances Piezocatalytic and Enzyodynamic Activities for Advanced Cancer TherapeuticsHaomiao Bai0Sujun Ding1Yanfei Dai2Jiefu Liu3Huangjing Chen4Wei Feng5Dehong Yu6Yu Chen7Xuejun Ni8Department of Medical Ultrasound Affiliated Hospital of Nantong University Nantong 226001 P. R. ChinaDepartment of Medical Ultrasound Affiliated Hospital of Nantong University Nantong 226001 P. R. ChinaRadiology Department Branch of Affiliated Hospital of Nantong University Nantong 226001 P. R. ChinaDepartment of Medical Ultrasound Affiliated Hospital of Nantong University Nantong 226001 P. R. ChinaDepartment of Medical Ultrasound Affiliated Hospital of Nantong University Nantong 226001 P. R. ChinaMaterdicine Lab School of Life Sciences Shanghai University Shanghai 200444 P. R. ChinaMaterdicine Lab School of Life Sciences Shanghai University Shanghai 200444 P. R. ChinaMaterdicine Lab School of Life Sciences Shanghai University Shanghai 200444 P. R. ChinaDepartment of Medical Ultrasound Affiliated Hospital of Nantong University Nantong 226001 P. R. ChinaAbstract Piezoelectric semiconductor nanomaterials have attracted considerable interest in piezocatalytic tumor treatment. However, piezocatalytic therapy encounters obstacles such as suboptimal piezoelectric responses, rapid electron‐hole recombination, inefficient energy harvesting, and the complexities of the tumor microenvironment. In this study, sulfur vacancy‐engineered cobalt (Co) single‐atom doped molybdenum disulfide (SA‐Co@MoS2) nanoflowers are strategically designed, which exhibit enhanced piezoelectric effects. Specifically, the introduction of Co single atom not only induces lattice distortion and out‐of‐plane polarization but also leads to the formation of numerous sulfur vacancies. These changes collectively narrow the intrinsic bandgap of the material, facilitating effective separation and migration of charge carriers, and enabling efficient production of reactive oxygen species under ultrasound stimulation. Additionally, the SA‐Co@MoS2 nanoflowers demonstrate improved enzymatic activity and exhibit glutathione depletion capabilities attributed to the mixed valence states of Co, intensifying oxidative stress in tumor cells, and leading to cell cycle arrest and apoptosis, while the inactivation of glutathione peroxidase 4 induces ferroptosis. Both in vitro and in vivo results indicate that SA‐Co@MoS2 nanoflowers can significantly eliminate tumor cells. This study offers valuable insights into the exploration of single‐atom doping‐enhanced piezoelectric sonosensitizers for cancer treatment, potentially paving the way for advancements in the field of piezocatalytic synergistic enzyodynamic therapy.https://doi.org/10.1002/advs.202415485enzyodynamic therapynanomedicinepiezocatalytic therapysingle‐atom doping |
| spellingShingle | Haomiao Bai Sujun Ding Yanfei Dai Jiefu Liu Huangjing Chen Wei Feng Dehong Yu Yu Chen Xuejun Ni Cobalt Single‐Atom Intercalation in Molybdenum Disulfide Enhances Piezocatalytic and Enzyodynamic Activities for Advanced Cancer Therapeutics Advanced Science enzyodynamic therapy nanomedicine piezocatalytic therapy single‐atom doping |
| title | Cobalt Single‐Atom Intercalation in Molybdenum Disulfide Enhances Piezocatalytic and Enzyodynamic Activities for Advanced Cancer Therapeutics |
| title_full | Cobalt Single‐Atom Intercalation in Molybdenum Disulfide Enhances Piezocatalytic and Enzyodynamic Activities for Advanced Cancer Therapeutics |
| title_fullStr | Cobalt Single‐Atom Intercalation in Molybdenum Disulfide Enhances Piezocatalytic and Enzyodynamic Activities for Advanced Cancer Therapeutics |
| title_full_unstemmed | Cobalt Single‐Atom Intercalation in Molybdenum Disulfide Enhances Piezocatalytic and Enzyodynamic Activities for Advanced Cancer Therapeutics |
| title_short | Cobalt Single‐Atom Intercalation in Molybdenum Disulfide Enhances Piezocatalytic and Enzyodynamic Activities for Advanced Cancer Therapeutics |
| title_sort | cobalt single atom intercalation in molybdenum disulfide enhances piezocatalytic and enzyodynamic activities for advanced cancer therapeutics |
| topic | enzyodynamic therapy nanomedicine piezocatalytic therapy single‐atom doping |
| url | https://doi.org/10.1002/advs.202415485 |
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