Dual role of miR-155 and exosomal miR-155 in tumor angiogenesis: implications for cancer progression and therapy

Dual role of miR-155 and exosomal miR-155 in tumor angiogenesis: implications for cancer progression and therapy

Abstract Tumor angiogenesis facilitates cancer progression by supporting tumor growth and metastasis. MicroRNA-155 (miR-155) plays a pivotal role in regulating angiogenesis through both direct effects on tumor and endothelial cells and indirect modulation via exosomal communication. This review high...

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Main Authors: Qusay Mohammed Hussain, Ali Fawzi Al-Hussainy, Gaurav Sanghvi, R. Roopashree, Aditya Kashyap, D. Alex Anand, Rajashree Panigrahi, Nargiz Shavazi, Sada Ghalib Taher, Mariem Alwan, Mahmood Jawad, Hiba Mushtaq
Format: Article
Language:English
Published: BMC 2025-05-01
Series:European Journal of Medical Research
Subjects:
Cancer
Angiogenesis
Exosome
MicroRNA-155
Online Access:https://doi.org/10.1186/s40001-025-02618-z
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Summary:Abstract Tumor angiogenesis facilitates cancer progression by supporting tumor growth and metastasis. MicroRNA-155 (miR-155) plays a pivotal role in regulating angiogenesis through both direct effects on tumor and endothelial cells and indirect modulation via exosomal communication. This review highlights miR-155’s pro-angiogenic influence on endothelial cell behavior and tumor microenvironment remodeling. Additionally, exosomal miR-155 enhances intercellular communication, promoting vascularization in several cancers. Emerging therapeutic strategies include miR-155 inhibition using antagomirs, exosome-mediated delivery systems, and modulation of pathways such as JAK2/STAT3 and TGF-β/SMAD2. Targeting miR-155 represents a promising approach to hinder tumor angiogenesis and improve cancer therapy outcomes.
ISSN:2047-783X

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