Genome-wide association study of myocarditis and pericarditis following COVID-19 vaccination
Abstract This genome-wide association study (GWAS) explores the genetic components of severe adverse events following COVID-19 vaccination, with focus on myocarditis and pericarditis. Three SNPs (rs536572545, rs146289966 and rs142297026) near the SCAF11 gene were linked to pericarditis, while rs5703...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-05-01
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| Series: | npj Vaccines |
| Online Access: | https://doi.org/10.1038/s41541-025-01139-4 |
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| _version_ | 1850278020116381696 |
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| author | Marco Cavalli Niclas Eriksson Tomasz Baron Ahmet Yalcinkaya Nils Landegren Petter Brodin Pär Hallberg Mia Wadelius |
| author_facet | Marco Cavalli Niclas Eriksson Tomasz Baron Ahmet Yalcinkaya Nils Landegren Petter Brodin Pär Hallberg Mia Wadelius |
| author_sort | Marco Cavalli |
| collection | DOAJ |
| description | Abstract This genome-wide association study (GWAS) explores the genetic components of severe adverse events following COVID-19 vaccination, with focus on myocarditis and pericarditis. Three SNPs (rs536572545, rs146289966 and rs142297026) near the SCAF11 gene were linked to pericarditis, while rs570375365 in the LRRC4C gene was associated with myocarditis. These findings suggest that genetic variants may influence inflammation pathways, providing a basis for further investigation into the immunological responses triggered by vaccines. |
| format | Article |
| id | doaj-art-0cdaf07266f24fb38aeeb2ee3b779f9e |
| institution | OA Journals |
| issn | 2059-0105 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Vaccines |
| spelling | doaj-art-0cdaf07266f24fb38aeeb2ee3b779f9e2025-08-20T01:49:40ZengNature Portfolionpj Vaccines2059-01052025-05-011011710.1038/s41541-025-01139-4Genome-wide association study of myocarditis and pericarditis following COVID-19 vaccinationMarco Cavalli0Niclas Eriksson1Tomasz Baron2Ahmet Yalcinkaya3Nils Landegren4Petter Brodin5Pär Hallberg6Mia Wadelius7Department of Medical Sciences, Clinical Pharmacogenomics, Science for Life Laboratory, Uppsala UniversityDepartment of Medical Sciences, Clinical Pharmacogenomics, Science for Life Laboratory, Uppsala UniversityDepartment of Medical Sciences, Cardiology, Uppsala Clinical Research Centre, Uppsala UniversityScience for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala UniversityScience for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala UniversityUnit for Clinical Pediatrics, Department of Women’s and Children’s Health, Karolinska InstitutetDepartment of Medical Sciences, Clinical Pharmacogenomics, Science for Life Laboratory, Uppsala UniversityDepartment of Medical Sciences, Clinical Pharmacogenomics, Science for Life Laboratory, Uppsala UniversityAbstract This genome-wide association study (GWAS) explores the genetic components of severe adverse events following COVID-19 vaccination, with focus on myocarditis and pericarditis. Three SNPs (rs536572545, rs146289966 and rs142297026) near the SCAF11 gene were linked to pericarditis, while rs570375365 in the LRRC4C gene was associated with myocarditis. These findings suggest that genetic variants may influence inflammation pathways, providing a basis for further investigation into the immunological responses triggered by vaccines.https://doi.org/10.1038/s41541-025-01139-4 |
| spellingShingle | Marco Cavalli Niclas Eriksson Tomasz Baron Ahmet Yalcinkaya Nils Landegren Petter Brodin Pär Hallberg Mia Wadelius Genome-wide association study of myocarditis and pericarditis following COVID-19 vaccination npj Vaccines |
| title | Genome-wide association study of myocarditis and pericarditis following COVID-19 vaccination |
| title_full | Genome-wide association study of myocarditis and pericarditis following COVID-19 vaccination |
| title_fullStr | Genome-wide association study of myocarditis and pericarditis following COVID-19 vaccination |
| title_full_unstemmed | Genome-wide association study of myocarditis and pericarditis following COVID-19 vaccination |
| title_short | Genome-wide association study of myocarditis and pericarditis following COVID-19 vaccination |
| title_sort | genome wide association study of myocarditis and pericarditis following covid 19 vaccination |
| url | https://doi.org/10.1038/s41541-025-01139-4 |
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