Association between lactate dehydrogenase levels and all-cause mortality in ICU patients with heart failure: a retrospective analysis of the MIMIC-IV database
Abstract Background Heart failure (HF) patients admitted to the intensive care unit (ICU) often face high short-term mortality rates. This study aims to investigate the relationship between lactate dehydrogenase (LDH) levels and all-cause mortality in critically ill patients with HF. Methods Data fr...
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2025-01-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | https://doi.org/10.1186/s12872-025-04513-1 |
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| author | Panxu Guo Hongfu Ding Xiaowan Li Danying Xie Ke Wang Wanmin Su XiaoJuan Yang Fang Nie Peixi Wang |
| author_facet | Panxu Guo Hongfu Ding Xiaowan Li Danying Xie Ke Wang Wanmin Su XiaoJuan Yang Fang Nie Peixi Wang |
| author_sort | Panxu Guo |
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| description | Abstract Background Heart failure (HF) patients admitted to the intensive care unit (ICU) often face high short-term mortality rates. This study aims to investigate the relationship between lactate dehydrogenase (LDH) levels and all-cause mortality in critically ill patients with HF. Methods Data from the MIMIC-IV database were extracted for subjects eligible for HF diagnosis. We utilized the restricted cubic spline (RCS) method, Kaplan-Meier (K-M) survival curves, and Cox regression analysis to assess the association between lactate dehydrogenase (LDH) levels and all-cause mortality in HF patients. Overlap weighting (OW) and subgroup analysis were employed to enhance the robustness and reliability of the study. Results A total of 3,065 subjects were enrolled in this study. RCS analysis revealed a nonlinear relationship between LDH levels and the risk of all-cause mortality in critically ill patients with HF, with a hazard ratio (HR) > 1 when LDH exceeded 315 U/L. The K-M survival curve indicated lower survival rates and shorter survival times in subjects with LDH ≥ 315 U/L. Elevated LDH levels were independently associated with increased in-hospital and 1-year mortality rates, with adjusted HR of 1.39 (95% CI: 1.16, 1.67) and 1.29 (95% CI: 1.14, 1.45), respectively. The results remained consistently robust in the OW analyses. Conclusions Elevated LDH levels were significantly associated with an increased risk of all-cause mortality in ICU-admitted HF patients. Further randomized trials are needed to confirm this association. |
| format | Article |
| id | doaj-art-0cda235e81614b109141145f0dd7e8c9 |
| institution | Kabale University |
| issn | 1471-2261 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
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| series | BMC Cardiovascular Disorders |
| spelling | doaj-art-0cda235e81614b109141145f0dd7e8c92025-02-02T12:07:47ZengBMCBMC Cardiovascular Disorders1471-22612025-01-0125111110.1186/s12872-025-04513-1Association between lactate dehydrogenase levels and all-cause mortality in ICU patients with heart failure: a retrospective analysis of the MIMIC-IV databasePanxu Guo0Hongfu Ding1Xiaowan Li2Danying Xie3Ke Wang4Wanmin Su5XiaoJuan Yang6Fang Nie7Peixi Wang8Nanhai Family Practice HospitalSchool of Nursing and Health, Henan UniversitySchool of Nursing and Health, Henan UniversitySchool of Nursing and Health, Henan UniversitySchool of Nursing and Health, Henan UniversityOperations Management Department, Shenzhen Longhua District People’s HospitalZhongshan City People’s HospitalZhongshan City People’s HospitalNanhai Family Practice HospitalAbstract Background Heart failure (HF) patients admitted to the intensive care unit (ICU) often face high short-term mortality rates. This study aims to investigate the relationship between lactate dehydrogenase (LDH) levels and all-cause mortality in critically ill patients with HF. Methods Data from the MIMIC-IV database were extracted for subjects eligible for HF diagnosis. We utilized the restricted cubic spline (RCS) method, Kaplan-Meier (K-M) survival curves, and Cox regression analysis to assess the association between lactate dehydrogenase (LDH) levels and all-cause mortality in HF patients. Overlap weighting (OW) and subgroup analysis were employed to enhance the robustness and reliability of the study. Results A total of 3,065 subjects were enrolled in this study. RCS analysis revealed a nonlinear relationship between LDH levels and the risk of all-cause mortality in critically ill patients with HF, with a hazard ratio (HR) > 1 when LDH exceeded 315 U/L. The K-M survival curve indicated lower survival rates and shorter survival times in subjects with LDH ≥ 315 U/L. Elevated LDH levels were independently associated with increased in-hospital and 1-year mortality rates, with adjusted HR of 1.39 (95% CI: 1.16, 1.67) and 1.29 (95% CI: 1.14, 1.45), respectively. The results remained consistently robust in the OW analyses. Conclusions Elevated LDH levels were significantly associated with an increased risk of all-cause mortality in ICU-admitted HF patients. Further randomized trials are needed to confirm this association.https://doi.org/10.1186/s12872-025-04513-1Lactate dehydrogenaseHeart failureIntensive care unitsMortalityMIMIC-IV |
| spellingShingle | Panxu Guo Hongfu Ding Xiaowan Li Danying Xie Ke Wang Wanmin Su XiaoJuan Yang Fang Nie Peixi Wang Association between lactate dehydrogenase levels and all-cause mortality in ICU patients with heart failure: a retrospective analysis of the MIMIC-IV database BMC Cardiovascular Disorders Lactate dehydrogenase Heart failure Intensive care units Mortality MIMIC-IV |
| title | Association between lactate dehydrogenase levels and all-cause mortality in ICU patients with heart failure: a retrospective analysis of the MIMIC-IV database |
| title_full | Association between lactate dehydrogenase levels and all-cause mortality in ICU patients with heart failure: a retrospective analysis of the MIMIC-IV database |
| title_fullStr | Association between lactate dehydrogenase levels and all-cause mortality in ICU patients with heart failure: a retrospective analysis of the MIMIC-IV database |
| title_full_unstemmed | Association between lactate dehydrogenase levels and all-cause mortality in ICU patients with heart failure: a retrospective analysis of the MIMIC-IV database |
| title_short | Association between lactate dehydrogenase levels and all-cause mortality in ICU patients with heart failure: a retrospective analysis of the MIMIC-IV database |
| title_sort | association between lactate dehydrogenase levels and all cause mortality in icu patients with heart failure a retrospective analysis of the mimic iv database |
| topic | Lactate dehydrogenase Heart failure Intensive care units Mortality MIMIC-IV |
| url | https://doi.org/10.1186/s12872-025-04513-1 |
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