Association between Diabetes Complications and the Triglyceride-Glucose Index in Hospitalized Patients with Type 2 Diabetes
Background. Triglyceride-glucose (TyG) index is a convenient indicator of insulin resistance. It has been shown to be associated with macrovascular and microvascular complications in nonhospitalized diabetic patients. However, whether TyG index is a risk factor of diabetes vascular complications in...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2021/8757996 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849309114386087936 |
|---|---|
| author | Ying Pan Shao Zhong Kaixin Zhou Zijian Tian Fei Chen Ziqing Liu Zhaoxu Geng Shaoyun Li Rong Huang Heyou Wang Weiqing Zou Ji Hu |
| author_facet | Ying Pan Shao Zhong Kaixin Zhou Zijian Tian Fei Chen Ziqing Liu Zhaoxu Geng Shaoyun Li Rong Huang Heyou Wang Weiqing Zou Ji Hu |
| author_sort | Ying Pan |
| collection | DOAJ |
| description | Background. Triglyceride-glucose (TyG) index is a convenient indicator of insulin resistance. It has been shown to be associated with macrovascular and microvascular complications in nonhospitalized diabetic patients. However, whether TyG index is a risk factor of diabetes vascular complications in hospitalized type 2 diabetic patients is unclear. We sought to explore the association between TyG index and the risk of macrovascular and microvascular complications in a large Chinese cohort of hospitalized patients. Method. A total of 4,721 patients with type 2 diabetes (T2D) who were hospitalized in the Department of Endocrinology, Kunshan Hospital Affiliated to Jiangsu University were enrolled between January 2015 and November 2020. TyG index was calculated as lnfasting triglycerides mg/dL×fasting glucose mg/dL/2. Measures of macrovascular complications included brachial-ankle pulse wave velocity (ba-PWV) and ankle-brachial index (ABI), whilst urine microalbumin (MAU), chronic kidney disease (CKD), and diabetic retinopathy (DR) were evaluated for microvascular complications. Logistic regressions were used to examine the association between TyG index and diabetes complications. Results. In univariate logistic regressions, higher TyG index was significantly (p<0.002) associated with increased odds of MAU (OR=1.39, 95% CI: [1.22~1.59]) and ABI (OR=1.31, 95% CI: [1.10-1.57]) but not CKD, DR, or ba-PWV. After controlling for confounders such as age, sex, and body mass index (BMI), TyG index remained strongly (p<0.002) associated with MAU and ABI. These associations were more pronounced (p<0.001) in patients with poor glycemic control or in the elderly. Conclusion. Hospitalized patients with an elevated TyG index were at a higher risk of lower limb vascular stenosis and nephric microvascular damage. Close monitoring of TyG index in patients with younger age or poor glycemic control could potentially reduce the burden of diabetes complications and prevent readmission. |
| format | Article |
| id | doaj-art-0cd36a6538774e65a27f30cda73236ec |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-0cd36a6538774e65a27f30cda73236ec2025-08-20T03:54:15ZengWileyJournal of Diabetes Research2314-67452314-67532021-01-01202110.1155/2021/87579968757996Association between Diabetes Complications and the Triglyceride-Glucose Index in Hospitalized Patients with Type 2 DiabetesYing Pan0Shao Zhong1Kaixin Zhou2Zijian Tian3Fei Chen4Ziqing Liu5Zhaoxu Geng6Shaoyun Li7Rong Huang8Heyou Wang9Weiqing Zou10Ji Hu11Department of Endocrinology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, ChinaDepartment of Endocrinology, Kunshan Hospital Affiliated to Jiangsu University, Kunshan, Jiangsu, ChinaCollege of Life Sciences, University of Chinese Academy of Sciences, Beijing, ChinaCollege of Life Sciences, University of Chinese Academy of Sciences, Beijing, ChinaCollege of Life Sciences, University of Chinese Academy of Sciences, Beijing, ChinaCollege of Life Sciences, University of Chinese Academy of Sciences, Beijing, ChinaInstitute of Biophysics, Chinese Academy of Sciences, Beijing, ChinaBig Data Laboratory, Renji Hospital, University of Chinese Academy of Sciences, Chongqing, ChinaBioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou, ChinaPenglang Community Health Service Center, Kunshan, Jiangsu, ChinaPenglang Community Health Service Center, Kunshan, Jiangsu, ChinaDepartment of Endocrinology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, ChinaBackground. Triglyceride-glucose (TyG) index is a convenient indicator of insulin resistance. It has been shown to be associated with macrovascular and microvascular complications in nonhospitalized diabetic patients. However, whether TyG index is a risk factor of diabetes vascular complications in hospitalized type 2 diabetic patients is unclear. We sought to explore the association between TyG index and the risk of macrovascular and microvascular complications in a large Chinese cohort of hospitalized patients. Method. A total of 4,721 patients with type 2 diabetes (T2D) who were hospitalized in the Department of Endocrinology, Kunshan Hospital Affiliated to Jiangsu University were enrolled between January 2015 and November 2020. TyG index was calculated as lnfasting triglycerides mg/dL×fasting glucose mg/dL/2. Measures of macrovascular complications included brachial-ankle pulse wave velocity (ba-PWV) and ankle-brachial index (ABI), whilst urine microalbumin (MAU), chronic kidney disease (CKD), and diabetic retinopathy (DR) were evaluated for microvascular complications. Logistic regressions were used to examine the association between TyG index and diabetes complications. Results. In univariate logistic regressions, higher TyG index was significantly (p<0.002) associated with increased odds of MAU (OR=1.39, 95% CI: [1.22~1.59]) and ABI (OR=1.31, 95% CI: [1.10-1.57]) but not CKD, DR, or ba-PWV. After controlling for confounders such as age, sex, and body mass index (BMI), TyG index remained strongly (p<0.002) associated with MAU and ABI. These associations were more pronounced (p<0.001) in patients with poor glycemic control or in the elderly. Conclusion. Hospitalized patients with an elevated TyG index were at a higher risk of lower limb vascular stenosis and nephric microvascular damage. Close monitoring of TyG index in patients with younger age or poor glycemic control could potentially reduce the burden of diabetes complications and prevent readmission.http://dx.doi.org/10.1155/2021/8757996 |
| spellingShingle | Ying Pan Shao Zhong Kaixin Zhou Zijian Tian Fei Chen Ziqing Liu Zhaoxu Geng Shaoyun Li Rong Huang Heyou Wang Weiqing Zou Ji Hu Association between Diabetes Complications and the Triglyceride-Glucose Index in Hospitalized Patients with Type 2 Diabetes Journal of Diabetes Research |
| title | Association between Diabetes Complications and the Triglyceride-Glucose Index in Hospitalized Patients with Type 2 Diabetes |
| title_full | Association between Diabetes Complications and the Triglyceride-Glucose Index in Hospitalized Patients with Type 2 Diabetes |
| title_fullStr | Association between Diabetes Complications and the Triglyceride-Glucose Index in Hospitalized Patients with Type 2 Diabetes |
| title_full_unstemmed | Association between Diabetes Complications and the Triglyceride-Glucose Index in Hospitalized Patients with Type 2 Diabetes |
| title_short | Association between Diabetes Complications and the Triglyceride-Glucose Index in Hospitalized Patients with Type 2 Diabetes |
| title_sort | association between diabetes complications and the triglyceride glucose index in hospitalized patients with type 2 diabetes |
| url | http://dx.doi.org/10.1155/2021/8757996 |
| work_keys_str_mv | AT yingpan associationbetweendiabetescomplicationsandthetriglycerideglucoseindexinhospitalizedpatientswithtype2diabetes AT shaozhong associationbetweendiabetescomplicationsandthetriglycerideglucoseindexinhospitalizedpatientswithtype2diabetes AT kaixinzhou associationbetweendiabetescomplicationsandthetriglycerideglucoseindexinhospitalizedpatientswithtype2diabetes AT zijiantian associationbetweendiabetescomplicationsandthetriglycerideglucoseindexinhospitalizedpatientswithtype2diabetes AT feichen associationbetweendiabetescomplicationsandthetriglycerideglucoseindexinhospitalizedpatientswithtype2diabetes AT ziqingliu associationbetweendiabetescomplicationsandthetriglycerideglucoseindexinhospitalizedpatientswithtype2diabetes AT zhaoxugeng associationbetweendiabetescomplicationsandthetriglycerideglucoseindexinhospitalizedpatientswithtype2diabetes AT shaoyunli associationbetweendiabetescomplicationsandthetriglycerideglucoseindexinhospitalizedpatientswithtype2diabetes AT ronghuang associationbetweendiabetescomplicationsandthetriglycerideglucoseindexinhospitalizedpatientswithtype2diabetes AT heyouwang associationbetweendiabetescomplicationsandthetriglycerideglucoseindexinhospitalizedpatientswithtype2diabetes AT weiqingzou associationbetweendiabetescomplicationsandthetriglycerideglucoseindexinhospitalizedpatientswithtype2diabetes AT jihu associationbetweendiabetescomplicationsandthetriglycerideglucoseindexinhospitalizedpatientswithtype2diabetes |