Factors Contributing to In-Hospital Mortality in Dengue: Insights from National Surveillance Data in Mexico (2020–2024)
This study aimed to identify the factors associated with all-cause in-hospital mortality in laboratory-confirmed dengue cases from 2020 to mid-2024. A nationwide retrospective cohort study was conducted in Mexico and data from 18,436 participants were analyzed. Risk ratios (RRs) and 95% confidence i...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-09-01
|
| Series: | Tropical Medicine and Infectious Disease |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2414-6366/9/9/202 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850259233534115840 |
|---|---|
| author | Eder Fernando Ríos-Bracamontes Oliver Mendoza-Cano Agustin Lugo-Radillo Ana Daniela Ortega-Ramírez Efrén Murillo-Zamora |
| author_facet | Eder Fernando Ríos-Bracamontes Oliver Mendoza-Cano Agustin Lugo-Radillo Ana Daniela Ortega-Ramírez Efrén Murillo-Zamora |
| author_sort | Eder Fernando Ríos-Bracamontes |
| collection | DOAJ |
| description | This study aimed to identify the factors associated with all-cause in-hospital mortality in laboratory-confirmed dengue cases from 2020 to mid-2024. A nationwide retrospective cohort study was conducted in Mexico and data from 18,436 participants were analyzed. Risk ratios (RRs) and 95% confidence intervals (CIs), estimated using generalized linear regression models, were used to evaluate the factors associated with all-cause in-hospital mortality risk. The overall case–fatality rate was 17.5 per 1000. In the multiple model, compared to dengue virus (DENV) 1 infections, DENV-2 (RR = 1.81, 95% CI 1.15–2.86) and DENV-3 (RR = 1.87, 95% CI 1.19–2.92) were associated with increased mortality risk. Patient characteristics, such as increasing age (RR = 1.02, 95% CI 1.01–1.03), type 2 diabetes mellitus (RR = 2.07, 95% CI 1.45–2.96), and chronic kidney disease (RR = 3.35, 95% CI 2.03–5.51), were also associated with an increased risk of a fatal outcome. We documented the influence of both the virus and individual susceptibility on mortality risk, underscoring the need for a comprehensive public health strategy for dengue. |
| format | Article |
| id | doaj-art-0cceddef653d4b17a9f26dfc042b90ba |
| institution | OA Journals |
| issn | 2414-6366 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Tropical Medicine and Infectious Disease |
| spelling | doaj-art-0cceddef653d4b17a9f26dfc042b90ba2025-08-20T01:55:53ZengMDPI AGTropical Medicine and Infectious Disease2414-63662024-09-019920210.3390/tropicalmed9090202Factors Contributing to In-Hospital Mortality in Dengue: Insights from National Surveillance Data in Mexico (2020–2024)Eder Fernando Ríos-Bracamontes0Oliver Mendoza-Cano1Agustin Lugo-Radillo2Ana Daniela Ortega-Ramírez3Efrén Murillo-Zamora4Departamento de Medicina Interna, Hospital General de Zona No. 1, Instituto Mexicano del Seguro Social, Av. Lapislázuli 250, Villa de Álvarez 28984, MexicoFacultad de Ingeniería Civil, Universidad de Colima, km. 9 Carretera Colima-Coquimatlán, Coquimatlán 28400, MexicoCONAHCyT—Facultad de Medicina y Cirugía, Universidad Autónoma Benito Juárez de Oaxaca, Ex Hacienda Aguilera S/N, Carr. a San Felipe del Agua, Oaxaca 68020, MexicoFacultad de Medicina, Universidad de Colima, Av. Universidad 333, Colima 28040, MexicoUnidad de Investigación en Epidemiología Clínica, Instituto Mexicano del Seguro Social, Av. Lapislázuli 250, Villa de Álvarez 28984, MexicoThis study aimed to identify the factors associated with all-cause in-hospital mortality in laboratory-confirmed dengue cases from 2020 to mid-2024. A nationwide retrospective cohort study was conducted in Mexico and data from 18,436 participants were analyzed. Risk ratios (RRs) and 95% confidence intervals (CIs), estimated using generalized linear regression models, were used to evaluate the factors associated with all-cause in-hospital mortality risk. The overall case–fatality rate was 17.5 per 1000. In the multiple model, compared to dengue virus (DENV) 1 infections, DENV-2 (RR = 1.81, 95% CI 1.15–2.86) and DENV-3 (RR = 1.87, 95% CI 1.19–2.92) were associated with increased mortality risk. Patient characteristics, such as increasing age (RR = 1.02, 95% CI 1.01–1.03), type 2 diabetes mellitus (RR = 2.07, 95% CI 1.45–2.96), and chronic kidney disease (RR = 3.35, 95% CI 2.03–5.51), were also associated with an increased risk of a fatal outcome. We documented the influence of both the virus and individual susceptibility on mortality risk, underscoring the need for a comprehensive public health strategy for dengue.https://www.mdpi.com/2414-6366/9/9/202denguedengue virushospital mortalitypublic health |
| spellingShingle | Eder Fernando Ríos-Bracamontes Oliver Mendoza-Cano Agustin Lugo-Radillo Ana Daniela Ortega-Ramírez Efrén Murillo-Zamora Factors Contributing to In-Hospital Mortality in Dengue: Insights from National Surveillance Data in Mexico (2020–2024) Tropical Medicine and Infectious Disease dengue dengue virus hospital mortality public health |
| title | Factors Contributing to In-Hospital Mortality in Dengue: Insights from National Surveillance Data in Mexico (2020–2024) |
| title_full | Factors Contributing to In-Hospital Mortality in Dengue: Insights from National Surveillance Data in Mexico (2020–2024) |
| title_fullStr | Factors Contributing to In-Hospital Mortality in Dengue: Insights from National Surveillance Data in Mexico (2020–2024) |
| title_full_unstemmed | Factors Contributing to In-Hospital Mortality in Dengue: Insights from National Surveillance Data in Mexico (2020–2024) |
| title_short | Factors Contributing to In-Hospital Mortality in Dengue: Insights from National Surveillance Data in Mexico (2020–2024) |
| title_sort | factors contributing to in hospital mortality in dengue insights from national surveillance data in mexico 2020 2024 |
| topic | dengue dengue virus hospital mortality public health |
| url | https://www.mdpi.com/2414-6366/9/9/202 |
| work_keys_str_mv | AT ederfernandoriosbracamontes factorscontributingtoinhospitalmortalityindengueinsightsfromnationalsurveillancedatainmexico20202024 AT olivermendozacano factorscontributingtoinhospitalmortalityindengueinsightsfromnationalsurveillancedatainmexico20202024 AT agustinlugoradillo factorscontributingtoinhospitalmortalityindengueinsightsfromnationalsurveillancedatainmexico20202024 AT anadanielaortegaramirez factorscontributingtoinhospitalmortalityindengueinsightsfromnationalsurveillancedatainmexico20202024 AT efrenmurillozamora factorscontributingtoinhospitalmortalityindengueinsightsfromnationalsurveillancedatainmexico20202024 |