The Relevance and Potential Role of Orbital Fat in Inflammatory Orbital Diseases: Implications for Diagnosis and Treatment
Abstract The orbit is an important structure within the skull that houses the eye, optic nerve, and extraocular muscles. It also contains adipose/fat tissue, which provides a protective cushion for these components. Inflammatory orbital disease can affect any or all components of the orbit, often ar...
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| Format: | Article |
| Language: | English |
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Adis, Springer Healthcare
2024-12-01
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| Series: | Ophthalmology and Therapy |
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| Online Access: | https://doi.org/10.1007/s40123-024-01079-7 |
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| author | Prince Dadson Peter Ngum Luis Eduardo Juarez-Orozco Michael Ntodie Piotr Loba |
| author_facet | Prince Dadson Peter Ngum Luis Eduardo Juarez-Orozco Michael Ntodie Piotr Loba |
| author_sort | Prince Dadson |
| collection | DOAJ |
| description | Abstract The orbit is an important structure within the skull that houses the eye, optic nerve, and extraocular muscles. It also contains adipose/fat tissue, which provides a protective cushion for these components. Inflammatory orbital disease can affect any or all components of the orbit, often arising from various underlying pathologic conditions, including autoimmune, infectious, and vascular diseases. Typical signs and symptoms of orbital inflammation include swelling, redness, pain, discomfort, and potential loss of function. The role of orbital fat in the pathogenesis of inflammatory orbital diseases has not been fully explored. This review aims to provide a comprehensive description of orbital fat, its relevance and the potential role in inflammatory diseases of the orbit, and the use of radiologic imaging studies for evaluating this fat depot in cases of as inflammatory orbital diseases. Additionally, this review discusses the various procedures available for the treatment and management of these conditions. A range of interventions, including pharmacotherapy and surgical procedures, will be evaluated as promising therapeutic options. This review also explores the characteristics and potential applications of orbital fat-derived stem cells, with an emphasis on their regenerative abilities and anti-inflammatory effects. Understanding the role of orbital fat and its contribution to inflammatory orbital diseases is essential for optimizing diagnostic and treatment strategies. |
| format | Article |
| id | doaj-art-0cc78c50e1cb4967beb9eabd28b432c9 |
| institution | Kabale University |
| issn | 2193-8245 2193-6528 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Ophthalmology and Therapy |
| spelling | doaj-art-0cc78c50e1cb4967beb9eabd28b432c92025-01-26T12:18:49ZengAdis, Springer HealthcareOphthalmology and Therapy2193-82452193-65282024-12-0114224728110.1007/s40123-024-01079-7The Relevance and Potential Role of Orbital Fat in Inflammatory Orbital Diseases: Implications for Diagnosis and TreatmentPrince Dadson0Peter Ngum1Luis Eduardo Juarez-Orozco2Michael Ntodie3Piotr Loba4Turku PET Centre, University of TurkuTurku Brain Injury Center, Turku University Hospital and University of TurkuTurku PET Centre, University of TurkuCentre for Optometry and Vision Science, Biomedical Sciences Research Institute, Ulster UniversityDepartment of Binocular Vision Pathophysiology and Strabismus, Medical University of LodzAbstract The orbit is an important structure within the skull that houses the eye, optic nerve, and extraocular muscles. It also contains adipose/fat tissue, which provides a protective cushion for these components. Inflammatory orbital disease can affect any or all components of the orbit, often arising from various underlying pathologic conditions, including autoimmune, infectious, and vascular diseases. Typical signs and symptoms of orbital inflammation include swelling, redness, pain, discomfort, and potential loss of function. The role of orbital fat in the pathogenesis of inflammatory orbital diseases has not been fully explored. This review aims to provide a comprehensive description of orbital fat, its relevance and the potential role in inflammatory diseases of the orbit, and the use of radiologic imaging studies for evaluating this fat depot in cases of as inflammatory orbital diseases. Additionally, this review discusses the various procedures available for the treatment and management of these conditions. A range of interventions, including pharmacotherapy and surgical procedures, will be evaluated as promising therapeutic options. This review also explores the characteristics and potential applications of orbital fat-derived stem cells, with an emphasis on their regenerative abilities and anti-inflammatory effects. Understanding the role of orbital fat and its contribution to inflammatory orbital diseases is essential for optimizing diagnostic and treatment strategies.https://doi.org/10.1007/s40123-024-01079-7Orbital fatInflammatory orbital diseaseDiagnosticTreatmentRadiologic imaging studies |
| spellingShingle | Prince Dadson Peter Ngum Luis Eduardo Juarez-Orozco Michael Ntodie Piotr Loba The Relevance and Potential Role of Orbital Fat in Inflammatory Orbital Diseases: Implications for Diagnosis and Treatment Ophthalmology and Therapy Orbital fat Inflammatory orbital disease Diagnostic Treatment Radiologic imaging studies |
| title | The Relevance and Potential Role of Orbital Fat in Inflammatory Orbital Diseases: Implications for Diagnosis and Treatment |
| title_full | The Relevance and Potential Role of Orbital Fat in Inflammatory Orbital Diseases: Implications for Diagnosis and Treatment |
| title_fullStr | The Relevance and Potential Role of Orbital Fat in Inflammatory Orbital Diseases: Implications for Diagnosis and Treatment |
| title_full_unstemmed | The Relevance and Potential Role of Orbital Fat in Inflammatory Orbital Diseases: Implications for Diagnosis and Treatment |
| title_short | The Relevance and Potential Role of Orbital Fat in Inflammatory Orbital Diseases: Implications for Diagnosis and Treatment |
| title_sort | relevance and potential role of orbital fat in inflammatory orbital diseases implications for diagnosis and treatment |
| topic | Orbital fat Inflammatory orbital disease Diagnostic Treatment Radiologic imaging studies |
| url | https://doi.org/10.1007/s40123-024-01079-7 |
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