Studyng the effects of Cantharellus cibarius fungi on Opisthorchis felineus trematode and on parasite host - C57BL/6 inbred mice
Opisthorchiasis is a dangerous parasitic disease caused by trematodes in the family Opisthorchiidae. One of the causes of this infection is the species Opisthorchis felineus, which is common in the Russian Federation and Western Europe. The disease has a large number of complications and relatively...
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| Format: | Article |
| Language: | English |
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Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders
2018-11-01
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| Series: | Вавиловский журнал генетики и селекции |
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| Online Access: | https://vavilov.elpub.ru/jour/article/view/1720 |
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| author | M. A. Tsyganov G. B. Vishnevetskaya T. P. Kukina I. V. Sorokina M. N. Lvova M. A. Protsenko N. E. Kostina D. F. Avgustinovich |
| author_facet | M. A. Tsyganov G. B. Vishnevetskaya T. P. Kukina I. V. Sorokina M. N. Lvova M. A. Protsenko N. E. Kostina D. F. Avgustinovich |
| author_sort | M. A. Tsyganov |
| collection | DOAJ |
| description | Opisthorchiasis is a dangerous parasitic disease caused by trematodes in the family Opisthorchiidae. One of the causes of this infection is the species Opisthorchis felineus, which is common in the Russian Federation and Western Europe. The disease has a large number of complications and relatively few effective treatments, so nowadays it is relevant to look for new drugs for the treatment of opisthorchiasis, with the maximum antiparasitic and minimal side effect. In this work, a potentially anthelmintic effect of the methanol extract of the golden chanterelle mushroom (Cantharellus cibarius) was investigated. In in vitro experiments, the significantly reduced mobility and survival rates of juvenile O. felineus specimens with increasing concentrations (10-1000 pg/ml) of the C. cibarius extract were shown. In in vivo studies, administration of the C. cibarius extract on the first day after parasitic infection of inbred C57BL/6 mice resulted in a decrease of the number of helminths in the bile ducts of the liver, evaluated 6 weeks after infection. In another series of experiments, administration of the C. cibarius extract for 7 days to mice infected with O. felineus for five weeks had no anthelmintic effect. In both cases, the state of the infected hosts, evaluated by a number of physiological and biochemical parameters (relative weight of organs, blood indices), did not deteriorate, indicating that there was no adverse effect of the C. cibarius extract. The results obtained suggest that the C. cibarius extract might have anthelmintic properties if applied as parasite larvae excyst. |
| format | Article |
| id | doaj-art-0cc33cb8e1734892a68e000a78ac1605 |
| institution | Kabale University |
| issn | 2500-3259 |
| language | English |
| publishDate | 2018-11-01 |
| publisher | Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders |
| record_format | Article |
| series | Вавиловский журнал генетики и селекции |
| spelling | doaj-art-0cc33cb8e1734892a68e000a78ac16052025-02-01T09:58:06ZengSiberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and BreedersВавиловский журнал генетики и селекции2500-32592018-11-0122785686310.18699/VJ18.426832Studyng the effects of Cantharellus cibarius fungi on Opisthorchis felineus trematode and on parasite host - C57BL/6 inbred miceM. A. Tsyganov0G. B. Vishnevetskaya1T. P. Kukina2I. V. Sorokina3M. N. Lvova4M. A. Protsenko5N. E. Kostina6D. F. Avgustinovich7Institute of Cytology and Genetics, SB RAS; Novosibirsk State UniversityInstitute of Cytology and Genetics, SB RASN.N. Vorozhtsov Novosibirsk Institute of organic Chemistry, SB RASN.N. Vorozhtsov Novosibirsk Institute of organic Chemistry, SB RASInstitute of Cytology and Genetics, SB RAS; Novosibirsk State Medical UniversityState Research Center of Virology and Biotechnology "Vector" KoltsovoInstitute of Cytology and Genetics, SB RASInstitute of Cytology and Genetics, SB RASOpisthorchiasis is a dangerous parasitic disease caused by trematodes in the family Opisthorchiidae. One of the causes of this infection is the species Opisthorchis felineus, which is common in the Russian Federation and Western Europe. The disease has a large number of complications and relatively few effective treatments, so nowadays it is relevant to look for new drugs for the treatment of opisthorchiasis, with the maximum antiparasitic and minimal side effect. In this work, a potentially anthelmintic effect of the methanol extract of the golden chanterelle mushroom (Cantharellus cibarius) was investigated. In in vitro experiments, the significantly reduced mobility and survival rates of juvenile O. felineus specimens with increasing concentrations (10-1000 pg/ml) of the C. cibarius extract were shown. In in vivo studies, administration of the C. cibarius extract on the first day after parasitic infection of inbred C57BL/6 mice resulted in a decrease of the number of helminths in the bile ducts of the liver, evaluated 6 weeks after infection. In another series of experiments, administration of the C. cibarius extract for 7 days to mice infected with O. felineus for five weeks had no anthelmintic effect. In both cases, the state of the infected hosts, evaluated by a number of physiological and biochemical parameters (relative weight of organs, blood indices), did not deteriorate, indicating that there was no adverse effect of the C. cibarius extract. The results obtained suggest that the C. cibarius extract might have anthelmintic properties if applied as parasite larvae excyst.https://vavilov.elpub.ru/jour/article/view/1720opisthorchis felineusmethanolic extract of cantharellus cibariusc57bl/6 miceblood biochemical markers |
| spellingShingle | M. A. Tsyganov G. B. Vishnevetskaya T. P. Kukina I. V. Sorokina M. N. Lvova M. A. Protsenko N. E. Kostina D. F. Avgustinovich Studyng the effects of Cantharellus cibarius fungi on Opisthorchis felineus trematode and on parasite host - C57BL/6 inbred mice Вавиловский журнал генетики и селекции opisthorchis felineus methanolic extract of cantharellus cibarius c57bl/6 mice blood biochemical markers |
| title | Studyng the effects of Cantharellus cibarius fungi on Opisthorchis felineus trematode and on parasite host - C57BL/6 inbred mice |
| title_full | Studyng the effects of Cantharellus cibarius fungi on Opisthorchis felineus trematode and on parasite host - C57BL/6 inbred mice |
| title_fullStr | Studyng the effects of Cantharellus cibarius fungi on Opisthorchis felineus trematode and on parasite host - C57BL/6 inbred mice |
| title_full_unstemmed | Studyng the effects of Cantharellus cibarius fungi on Opisthorchis felineus trematode and on parasite host - C57BL/6 inbred mice |
| title_short | Studyng the effects of Cantharellus cibarius fungi on Opisthorchis felineus trematode and on parasite host - C57BL/6 inbred mice |
| title_sort | studyng the effects of cantharellus cibarius fungi on opisthorchis felineus trematode and on parasite host c57bl 6 inbred mice |
| topic | opisthorchis felineus methanolic extract of cantharellus cibarius c57bl/6 mice blood biochemical markers |
| url | https://vavilov.elpub.ru/jour/article/view/1720 |
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