Update on NKCC2 regulation in the thick ascending limb (TAL) by membrane trafficking, phosphorylation, and protein-protein interactions

Update on NKCC2 regulation in the thick ascending limb (TAL) by membrane trafficking, phosphorylation, and protein-protein interactions

Purpose of reviewThe thick ascending limb (TAL) of loop of Henle is essential for NaCl, calcium and magnesium homeostasis, pH balance and for urine concentration. NKCC2 is the main transporter for NaCl reabsorption in the TAL and its regulation is very complex. There have been recent advancements to...

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Bibliographic Details
Main Authors: Dipak Maskey, Jessica Granados Pineda, Pablo A. Ortiz
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Physiology
Subjects:
thick ascending limb
SLC12A1
NKCC2
protein-protein interactions
proteomics
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2024.1508806/full
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