Molecular Age-Related Changes in the Anterior Segment of the Eye
Purpose. To examine the current knowledge about the age-related processes in the anterior segment of the eye at a biological, clinical, and molecular level. Methods. We reviewed the available published literature that addresses the aging process of the anterior segment of the eye and its associated...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2017/1295132 |
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| author | Luis Fernando Hernandez-Zimbron Rosario Gulias-Cañizo María F. Golzarri Blanca Elizabeth Martínez-Báez Hugo Quiroz-Mercado Roberto Gonzalez-Salinas |
| author_facet | Luis Fernando Hernandez-Zimbron Rosario Gulias-Cañizo María F. Golzarri Blanca Elizabeth Martínez-Báez Hugo Quiroz-Mercado Roberto Gonzalez-Salinas |
| author_sort | Luis Fernando Hernandez-Zimbron |
| collection | DOAJ |
| description | Purpose. To examine the current knowledge about the age-related processes in the anterior segment of the eye at a biological, clinical, and molecular level. Methods. We reviewed the available published literature that addresses the aging process of the anterior segment of the eye and its associated molecular and physiological events. We performed a search on PubMed, CINAHL, and Embase using the MeSH terms “eye,” “anterior segment,” and “age.” We generated searches to account for synonyms of these keywords and MESH headings as follows: (1) “Eye” AND “ageing process” OR “anterior segment ageing” and (2) “Anterior segment” AND “ageing process” OR “anterior segment” AND “molecular changes” AND “age.” Results. Among the principal causes of age-dependent alterations in the anterior segment of the eye, we found the mutation of the TGF-β gene and loss of autophagy in addition to oxidative stress, which contributes to the pathogenesis of degenerative diseases. Conclusions. In this review, we summarize the current knowledge regarding some of the molecular mechanisms related to aging in the anterior segment of the eye. We also introduce and propose potential roles of autophagy, an important mechanism responsible for maintaining homeostasis and proteostasis under stress conditions in the anterior segment during aging. |
| format | Article |
| id | doaj-art-0cc20f48cc5540bbbc4e42bced088411 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-0cc20f48cc5540bbbc4e42bced0884112025-02-03T06:06:01ZengWileyJournal of Ophthalmology2090-004X2090-00582017-01-01201710.1155/2017/12951321295132Molecular Age-Related Changes in the Anterior Segment of the EyeLuis Fernando Hernandez-Zimbron0Rosario Gulias-Cañizo1María F. Golzarri2Blanca Elizabeth Martínez-Báez3Hugo Quiroz-Mercado4Roberto Gonzalez-Salinas5Research Department, Asociación para Evitar la Ceguera “Hospital Luis Sanchez Bulnes”, I.A.P., 04030 México City, MexicoResearch Department, Asociación para Evitar la Ceguera “Hospital Luis Sanchez Bulnes”, I.A.P., 04030 México City, MexicoAnterior Segment Surgery Department, Asociación para Evitar la Ceguera “Hospital Luis Sanchez Bulnes”, I.A.P., 04030 México City, MexicoAnterior Segment Surgery Department, Asociación para Evitar la Ceguera “Hospital Luis Sanchez Bulnes”, I.A.P., 04030 México City, MexicoResearch Department, Asociación para Evitar la Ceguera “Hospital Luis Sanchez Bulnes”, I.A.P., 04030 México City, MexicoResearch Department, Asociación para Evitar la Ceguera “Hospital Luis Sanchez Bulnes”, I.A.P., 04030 México City, MexicoPurpose. To examine the current knowledge about the age-related processes in the anterior segment of the eye at a biological, clinical, and molecular level. Methods. We reviewed the available published literature that addresses the aging process of the anterior segment of the eye and its associated molecular and physiological events. We performed a search on PubMed, CINAHL, and Embase using the MeSH terms “eye,” “anterior segment,” and “age.” We generated searches to account for synonyms of these keywords and MESH headings as follows: (1) “Eye” AND “ageing process” OR “anterior segment ageing” and (2) “Anterior segment” AND “ageing process” OR “anterior segment” AND “molecular changes” AND “age.” Results. Among the principal causes of age-dependent alterations in the anterior segment of the eye, we found the mutation of the TGF-β gene and loss of autophagy in addition to oxidative stress, which contributes to the pathogenesis of degenerative diseases. Conclusions. In this review, we summarize the current knowledge regarding some of the molecular mechanisms related to aging in the anterior segment of the eye. We also introduce and propose potential roles of autophagy, an important mechanism responsible for maintaining homeostasis and proteostasis under stress conditions in the anterior segment during aging.http://dx.doi.org/10.1155/2017/1295132 |
| spellingShingle | Luis Fernando Hernandez-Zimbron Rosario Gulias-Cañizo María F. Golzarri Blanca Elizabeth Martínez-Báez Hugo Quiroz-Mercado Roberto Gonzalez-Salinas Molecular Age-Related Changes in the Anterior Segment of the Eye Journal of Ophthalmology |
| title | Molecular Age-Related Changes in the Anterior Segment of the Eye |
| title_full | Molecular Age-Related Changes in the Anterior Segment of the Eye |
| title_fullStr | Molecular Age-Related Changes in the Anterior Segment of the Eye |
| title_full_unstemmed | Molecular Age-Related Changes in the Anterior Segment of the Eye |
| title_short | Molecular Age-Related Changes in the Anterior Segment of the Eye |
| title_sort | molecular age related changes in the anterior segment of the eye |
| url | http://dx.doi.org/10.1155/2017/1295132 |
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