Bevacizumab Results in Ongoing Resolution of Bleeding From Gastrointestinal Arteriovenous Malformations After Treatment Discontinuation
Angiodysplasias cause gastrointestinal (GI) bleeding in patients with end-stage renal disease (ESRD). We present a novel case of a 62-year-old man with a history of recurrent GI bleeding requiring multiple transfusions secondary to angiodysplasias in the stomach, duodenum, and small bowel. Therapeut...
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| Format: | Article |
| Language: | English |
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American College of Physicians
2025-05-01
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| Series: | Annals of Internal Medicine: Clinical Cases |
| Online Access: | https://www.acpjournals.org/doi/10.7326/aimcc.2024.1352 |
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| author | Anand Shah Ritik Goyal Ankit S. Shah |
| author_facet | Anand Shah Ritik Goyal Ankit S. Shah |
| author_sort | Anand Shah |
| collection | DOAJ |
| description | Angiodysplasias cause gastrointestinal (GI) bleeding in patients with end-stage renal disease (ESRD). We present a novel case of a 62-year-old man with a history of recurrent GI bleeding requiring multiple transfusions secondary to angiodysplasias in the stomach, duodenum, and small bowel. Therapeutic endoscopic treatments were ineffective and, in total, required 40 units of packed red blood cells in 1 year. He was treated with bevacizumab and achieved a dramatic response of being transfusion free after the first dose. While various treatments for bleeding angiodysplasias exist, refractory cases require innovative approaches. Our case illustrates the successful use of bevacizumab in managing transfusion-dependent anemia secondary to angiodysplasias in ESRD. |
| format | Article |
| id | doaj-art-0cc1bb321d934fb78e10a56cb982bc4d |
| institution | DOAJ |
| issn | 2767-7664 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | American College of Physicians |
| record_format | Article |
| series | Annals of Internal Medicine: Clinical Cases |
| spelling | doaj-art-0cc1bb321d934fb78e10a56cb982bc4d2025-08-20T03:08:17ZengAmerican College of PhysiciansAnnals of Internal Medicine: Clinical Cases2767-76642025-05-014510.7326/aimcc.2024.1352Bevacizumab Results in Ongoing Resolution of Bleeding From Gastrointestinal Arteriovenous Malformations After Treatment DiscontinuationAnand Shah0Ritik Goyal1Ankit S. Shah21Department of Medicine, Rutgers New Jersey Medical School, Newark, New Jersey1Department of Medicine, Rutgers New Jersey Medical School, Newark, New Jersey1Department of Medicine, Rutgers New Jersey Medical School, Newark, New JerseyAngiodysplasias cause gastrointestinal (GI) bleeding in patients with end-stage renal disease (ESRD). We present a novel case of a 62-year-old man with a history of recurrent GI bleeding requiring multiple transfusions secondary to angiodysplasias in the stomach, duodenum, and small bowel. Therapeutic endoscopic treatments were ineffective and, in total, required 40 units of packed red blood cells in 1 year. He was treated with bevacizumab and achieved a dramatic response of being transfusion free after the first dose. While various treatments for bleeding angiodysplasias exist, refractory cases require innovative approaches. Our case illustrates the successful use of bevacizumab in managing transfusion-dependent anemia secondary to angiodysplasias in ESRD.https://www.acpjournals.org/doi/10.7326/aimcc.2024.1352 |
| spellingShingle | Anand Shah Ritik Goyal Ankit S. Shah Bevacizumab Results in Ongoing Resolution of Bleeding From Gastrointestinal Arteriovenous Malformations After Treatment Discontinuation Annals of Internal Medicine: Clinical Cases |
| title | Bevacizumab Results in Ongoing Resolution of Bleeding From Gastrointestinal Arteriovenous Malformations After Treatment Discontinuation |
| title_full | Bevacizumab Results in Ongoing Resolution of Bleeding From Gastrointestinal Arteriovenous Malformations After Treatment Discontinuation |
| title_fullStr | Bevacizumab Results in Ongoing Resolution of Bleeding From Gastrointestinal Arteriovenous Malformations After Treatment Discontinuation |
| title_full_unstemmed | Bevacizumab Results in Ongoing Resolution of Bleeding From Gastrointestinal Arteriovenous Malformations After Treatment Discontinuation |
| title_short | Bevacizumab Results in Ongoing Resolution of Bleeding From Gastrointestinal Arteriovenous Malformations After Treatment Discontinuation |
| title_sort | bevacizumab results in ongoing resolution of bleeding from gastrointestinal arteriovenous malformations after treatment discontinuation |
| url | https://www.acpjournals.org/doi/10.7326/aimcc.2024.1352 |
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