Evaluation of the efficacy of a novel perfusion solution for normothermic ex vivo lung perfusion compared with Steen solution™ (animal experimental study)
Respiratory diseases, together with infectious complications and hereditary lung diseases, rank third in international mortality statistics. Today, lung transplantation is a recognized method of treating end-stage lung diseases. However, the number of transplant surgeries performed is not much. This...
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| Format: | Article |
| Language: | Russian |
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Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
2021-09-01
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| Series: | Вестник трансплантологии и искусственных органов |
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| Online Access: | https://journal.transpl.ru/vtio/article/view/1387 |
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| author | S. V. Gautier O. M. Tsirulnikova I. V. Pashkov N. V. Grudinin D. O. Oleshkevich D. M. Bondarenko N. P. Моzheikо A. A. Karpov N. S. Bunenkov |
| author_facet | S. V. Gautier O. M. Tsirulnikova I. V. Pashkov N. V. Grudinin D. O. Oleshkevich D. M. Bondarenko N. P. Моzheikо A. A. Karpov N. S. Bunenkov |
| author_sort | S. V. Gautier |
| collection | DOAJ |
| description | Respiratory diseases, together with infectious complications and hereditary lung diseases, rank third in international mortality statistics. Today, lung transplantation is a recognized method of treating end-stage lung diseases. However, the number of transplant surgeries performed is not much. This is down to the high requirements on the condition of a potential lung donor and directly on the quality of the donor lung. This has significantly limited the number of optimal donors. Rehabilitation of donor lungs to optimal gas exchange indicators can be achieved and objectively assessed in the course of ex vivo lung perfusion (EVLP). The EVLP procedure is widespread in leading transplantation centers in Europe and North America. It allows to significantly expand the pool of donor lungs, thereby serving a greater number of patients in need of lung transplantation. The possibility of EVLP procedure using publicly available perfusion equipment was demonstrated. The optimized protocol fully demonstrated its reliability and efficiency. The developed perfusion solution had no statistically significant differences in comparison with the Steen SolutionTM, which in the future will serve as an alternative for EVLP procedure. |
| format | Article |
| id | doaj-art-0cb4121a735d4950891fe20169cc2f64 |
| institution | DOAJ |
| issn | 1995-1191 |
| language | Russian |
| publishDate | 2021-09-01 |
| publisher | Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov |
| record_format | Article |
| series | Вестник трансплантологии и искусственных органов |
| spelling | doaj-art-0cb4121a735d4950891fe20169cc2f642025-08-20T03:01:37ZrusFederal Research Center of Transplantology and Artificial Organs named after V.I.ShumakovВестник трансплантологии и искусственных органов1995-11912021-09-01233828910.15825/1995-1191-2021-3-82-891027Evaluation of the efficacy of a novel perfusion solution for normothermic ex vivo lung perfusion compared with Steen solution™ (animal experimental study)S. V. Gautier0O. M. Tsirulnikova1I. V. Pashkov2N. V. Grudinin3D. O. Oleshkevich4D. M. Bondarenko5N. P. Моzheikо6A. A. Karpov7N. S. Bunenkov8Shumakov National Medical Research Center of Transplantology and Artificial Organs; Sechenov UniversityShumakov National Medical Research Center of Transplantology and Artificial Organs; Sechenov UniversityShumakov National Medical Research Center of Transplantology and Artificial OrgansShumakov National Medical Research Center of Transplantology and Artificial OrgansShumakov National Medical Research Center of Transplantology and Artificial OrgansShumakov National Medical Research Center of Transplantology and Artificial OrgansShumakov National Medical Research Center of Transplantology and Artificial OrgansAlmazov National Medical Research CentrePavlov First St. Petersburg State Medical UniversityRespiratory diseases, together with infectious complications and hereditary lung diseases, rank third in international mortality statistics. Today, lung transplantation is a recognized method of treating end-stage lung diseases. However, the number of transplant surgeries performed is not much. This is down to the high requirements on the condition of a potential lung donor and directly on the quality of the donor lung. This has significantly limited the number of optimal donors. Rehabilitation of donor lungs to optimal gas exchange indicators can be achieved and objectively assessed in the course of ex vivo lung perfusion (EVLP). The EVLP procedure is widespread in leading transplantation centers in Europe and North America. It allows to significantly expand the pool of donor lungs, thereby serving a greater number of patients in need of lung transplantation. The possibility of EVLP procedure using publicly available perfusion equipment was demonstrated. The optimized protocol fully demonstrated its reliability and efficiency. The developed perfusion solution had no statistically significant differences in comparison with the Steen SolutionTM, which in the future will serve as an alternative for EVLP procedure.https://journal.transpl.ru/vtio/article/view/1387lung transplantationdonationex vivo lung perfusion |
| spellingShingle | S. V. Gautier O. M. Tsirulnikova I. V. Pashkov N. V. Grudinin D. O. Oleshkevich D. M. Bondarenko N. P. Моzheikо A. A. Karpov N. S. Bunenkov Evaluation of the efficacy of a novel perfusion solution for normothermic ex vivo lung perfusion compared with Steen solution™ (animal experimental study) Вестник трансплантологии и искусственных органов lung transplantation donation ex vivo lung perfusion |
| title | Evaluation of the efficacy of a novel perfusion solution for normothermic ex vivo lung perfusion compared with Steen solution™ (animal experimental study) |
| title_full | Evaluation of the efficacy of a novel perfusion solution for normothermic ex vivo lung perfusion compared with Steen solution™ (animal experimental study) |
| title_fullStr | Evaluation of the efficacy of a novel perfusion solution for normothermic ex vivo lung perfusion compared with Steen solution™ (animal experimental study) |
| title_full_unstemmed | Evaluation of the efficacy of a novel perfusion solution for normothermic ex vivo lung perfusion compared with Steen solution™ (animal experimental study) |
| title_short | Evaluation of the efficacy of a novel perfusion solution for normothermic ex vivo lung perfusion compared with Steen solution™ (animal experimental study) |
| title_sort | evaluation of the efficacy of a novel perfusion solution for normothermic ex vivo lung perfusion compared with steen solution™ animal experimental study |
| topic | lung transplantation donation ex vivo lung perfusion |
| url | https://journal.transpl.ru/vtio/article/view/1387 |
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