Lennox-gastaut syndrome in a pediatric patient with prader-willi syndrome: A case report and review
Prader-Willi Syndrome is typically caused by paternal deletion of chromosome 15q11-q13. It involves multiple systems and is commonly associated with hypotonia, global developmental delay, and endocrine abnormalities. Seizures are less frequently reported in individuals with Prader-Willi syndrome. He...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Brain Disorders |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666459325000216 |
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| author | Raidah Albaradie Sharook Alhawaj Wojod Alothman Shahid Bashir |
| author_facet | Raidah Albaradie Sharook Alhawaj Wojod Alothman Shahid Bashir |
| author_sort | Raidah Albaradie |
| collection | DOAJ |
| description | Prader-Willi Syndrome is typically caused by paternal deletion of chromosome 15q11-q13. It involves multiple systems and is commonly associated with hypotonia, global developmental delay, and endocrine abnormalities. Seizures are less frequently reported in individuals with Prader-Willi syndrome. Here, we present a rare case of a 3-year-old boy presenting with early-onset tonic seizures, global developmental delay, and an EEG showing a Lennox-Gastaut Syndrome-like pattern. Notably, brain MRI results were normal. This case represents previously unreported co-occurrence of Lennox-Gastaut Syndrome in a pediatric patient with Prader-Willi Syndrome. |
| format | Article |
| id | doaj-art-0cb357a8d9634f818fe0a853cc5eb833 |
| institution | DOAJ |
| issn | 2666-4593 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Disorders |
| spelling | doaj-art-0cb357a8d9634f818fe0a853cc5eb8332025-08-20T02:50:29ZengElsevierBrain Disorders2666-45932025-03-011710020110.1016/j.dscb.2025.100201Lennox-gastaut syndrome in a pediatric patient with prader-willi syndrome: A case report and reviewRaidah Albaradie0Sharook Alhawaj1Wojod Alothman2Shahid Bashir3Department of Pediatric neurology, Neuroscience Center, King Fahad Specialist Hospital, Dammam, Saudi Arabia; Corresponding author at: Neuroscience Center, King Fahad Specialist Hospital Dammam, Dammam, Saudi Arabia, P.O. Box 15215, Dammam, 31444, Saudi Arabia.Department of Pediatric neurology, Neuroscience Center, King Fahad Specialist Hospital, Dammam, Saudi ArabiaImam Abdulrahman bin Faisal University, College of Medicine, Dammam, Saudi ArabiaNeuroscience Center, King Fahad Specialist Hospital, Dammam, Saudi Arabia; King Salman Center for Disability Research, Riyadh, 11614, Saudi ArabiaPrader-Willi Syndrome is typically caused by paternal deletion of chromosome 15q11-q13. It involves multiple systems and is commonly associated with hypotonia, global developmental delay, and endocrine abnormalities. Seizures are less frequently reported in individuals with Prader-Willi syndrome. Here, we present a rare case of a 3-year-old boy presenting with early-onset tonic seizures, global developmental delay, and an EEG showing a Lennox-Gastaut Syndrome-like pattern. Notably, brain MRI results were normal. This case represents previously unreported co-occurrence of Lennox-Gastaut Syndrome in a pediatric patient with Prader-Willi Syndrome.http://www.sciencedirect.com/science/article/pii/S2666459325000216Prader-Willi Syndromeseizuredrop attacksLennox-Gastaut Syndrome |
| spellingShingle | Raidah Albaradie Sharook Alhawaj Wojod Alothman Shahid Bashir Lennox-gastaut syndrome in a pediatric patient with prader-willi syndrome: A case report and review Brain Disorders Prader-Willi Syndrome seizure drop attacks Lennox-Gastaut Syndrome |
| title | Lennox-gastaut syndrome in a pediatric patient with prader-willi syndrome: A case report and review |
| title_full | Lennox-gastaut syndrome in a pediatric patient with prader-willi syndrome: A case report and review |
| title_fullStr | Lennox-gastaut syndrome in a pediatric patient with prader-willi syndrome: A case report and review |
| title_full_unstemmed | Lennox-gastaut syndrome in a pediatric patient with prader-willi syndrome: A case report and review |
| title_short | Lennox-gastaut syndrome in a pediatric patient with prader-willi syndrome: A case report and review |
| title_sort | lennox gastaut syndrome in a pediatric patient with prader willi syndrome a case report and review |
| topic | Prader-Willi Syndrome seizure drop attacks Lennox-Gastaut Syndrome |
| url | http://www.sciencedirect.com/science/article/pii/S2666459325000216 |
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