SINGLE NUCLEOTIDE POLYMORPHISMS WITHIN GENES REGULATING IMMUNE RESPONSE AND ANTIOXIDANT DEFENCE IN PATIENTS WITH COLORECTAL AND GASTRIC CANCER
Background. During the recent decade, studies on inherited variation within innate immune response and antioxidant defense genes and cancer highlighted a number of significant associations; however, this is not the case for colorectal cancer. Aim. ofIL1B_1473G/C (rs1143623), SOD1_7958A/G (rs499855...
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| Format: | Article |
| Language: | Russian |
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The Publishing House Medicine and Enlightenment
2017-03-01
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| Series: | Медицина в Кузбассе |
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| Online Access: | http://mednauki.ru/index.php/MK/article/view/64 |
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| author | Асия Дамировна Падюкова Арсений Евгеньевич Южалин Антон Геннадьевич Кутихин Алексей Николаевич Волков Юлия Александровна Попова Алексей Станиславович Животовский Юрий Абрамович Магарилл Евгений Анатольевич Цитко Елена Борисовна Брусина |
| author_facet | Асия Дамировна Падюкова Арсений Евгеньевич Южалин Антон Геннадьевич Кутихин Алексей Николаевич Волков Юлия Александровна Попова Алексей Станиславович Животовский Юрий Абрамович Магарилл Евгений Анатольевич Цитко Елена Борисовна Брусина |
| author_sort | Асия Дамировна Падюкова |
| collection | DOAJ |
| description | Background. During the recent decade, studies on inherited variation within innate immune response and antioxidant defense genes and cancer highlighted a number of significant associations; however, this is not the case for colorectal cancer.
Aim. ofIL1B_1473G/C (rs1143623), SOD1_7958A/G (rs4998557), TLR4_1196C/T (rs4986791), IL10_1082A/G (rs1800896), IL17A_197G/A (rs2275913), andTLR4_896A/G (rs4986790) polymorphisms with colorectal and gastric cancer.
Materials and methods. We recruited 244 consecutive patients with colorectal cancer and 72 patients with gastric canceralong with 300 age- and gender-matched asymptomatic individuals. Genotyping was carried out using allele-specific polymerasechain reaction following electrophoretic detection. Statistical analysis was performed bySNPStats software.
Results. We revealed that heterozygous genotypes of theIL1B_1473G/C and TLR4_896A/G polymorphisms were significantly associated with a higher risk of colorectal cancer, particularly rectal cancer. Incontrast, C/Cgenotypeof the IL1B_1473G/C polymorphism was significantly associated with a lower risk of colon cancer.
Conclusion. Polymorphisms within the genes encoding interleukins and Toll-like receptors may play a role in the development of colorectal cancer. |
| format | Article |
| id | doaj-art-0cb0fc33ed8a4bf796a8445efaacc0b0 |
| institution | Kabale University |
| issn | 1819-0901 |
| language | Russian |
| publishDate | 2017-03-01 |
| publisher | The Publishing House Medicine and Enlightenment |
| record_format | Article |
| series | Медицина в Кузбассе |
| spelling | doaj-art-0cb0fc33ed8a4bf796a8445efaacc0b02025-08-20T03:33:15ZrusThe Publishing House Medicine and EnlightenmentМедицина в Кузбассе1819-09012017-03-01161505655SINGLE NUCLEOTIDE POLYMORPHISMS WITHIN GENES REGULATING IMMUNE RESPONSE AND ANTIOXIDANT DEFENCE IN PATIENTS WITH COLORECTAL AND GASTRIC CANCERАсия Дамировна Падюкова0Арсений Евгеньевич Южалин1Антон Геннадьевич Кутихин2Алексей Николаевич Волков3Юлия Александровна Попова4Алексей Станиславович Животовский5Юрий Абрамович Магарилл6Евгений Анатольевич Цитко7Елена Борисовна Брусина8ФГБОУ ВО КемГМУ Минздрава России, г. КемеровоОксфордский институт радиационной онкологии, Оксфордский университетФГБНУ «НИИ КПССЗ», г. КемеровоФГБОУ ВО КемГМУ Минздрава России, г. КемеровоФГБОУ ВО КемГМУ Минздрава России, г. КемеровоГБУЗ КО «Областной клинический онкологический диспансер», г. КемеровоФГБОУ ВО КемГМУ Минздрава России, г. КемеровоФГБОУ ВО КемГМУ Минздрава России, г. КемеровоФГБОУ ВО КемГМУ Минздрава России, г. КемеровоBackground. During the recent decade, studies on inherited variation within innate immune response and antioxidant defense genes and cancer highlighted a number of significant associations; however, this is not the case for colorectal cancer. Aim. ofIL1B_1473G/C (rs1143623), SOD1_7958A/G (rs4998557), TLR4_1196C/T (rs4986791), IL10_1082A/G (rs1800896), IL17A_197G/A (rs2275913), andTLR4_896A/G (rs4986790) polymorphisms with colorectal and gastric cancer. Materials and methods. We recruited 244 consecutive patients with colorectal cancer and 72 patients with gastric canceralong with 300 age- and gender-matched asymptomatic individuals. Genotyping was carried out using allele-specific polymerasechain reaction following electrophoretic detection. Statistical analysis was performed bySNPStats software. Results. We revealed that heterozygous genotypes of theIL1B_1473G/C and TLR4_896A/G polymorphisms were significantly associated with a higher risk of colorectal cancer, particularly rectal cancer. Incontrast, C/Cgenotypeof the IL1B_1473G/C polymorphism was significantly associated with a lower risk of colon cancer. Conclusion. Polymorphisms within the genes encoding interleukins and Toll-like receptors may play a role in the development of colorectal cancer.http://mednauki.ru/index.php/MK/article/view/64колоректальный ракрак желудкагеныполиморфизмыгенетические факторы риска |
| spellingShingle | Асия Дамировна Падюкова Арсений Евгеньевич Южалин Антон Геннадьевич Кутихин Алексей Николаевич Волков Юлия Александровна Попова Алексей Станиславович Животовский Юрий Абрамович Магарилл Евгений Анатольевич Цитко Елена Борисовна Брусина SINGLE NUCLEOTIDE POLYMORPHISMS WITHIN GENES REGULATING IMMUNE RESPONSE AND ANTIOXIDANT DEFENCE IN PATIENTS WITH COLORECTAL AND GASTRIC CANCER Медицина в Кузбассе колоректальный рак рак желудка гены полиморфизмы генетические факторы риска |
| title | SINGLE NUCLEOTIDE POLYMORPHISMS WITHIN GENES REGULATING IMMUNE RESPONSE AND ANTIOXIDANT DEFENCE IN PATIENTS WITH COLORECTAL AND GASTRIC CANCER |
| title_full | SINGLE NUCLEOTIDE POLYMORPHISMS WITHIN GENES REGULATING IMMUNE RESPONSE AND ANTIOXIDANT DEFENCE IN PATIENTS WITH COLORECTAL AND GASTRIC CANCER |
| title_fullStr | SINGLE NUCLEOTIDE POLYMORPHISMS WITHIN GENES REGULATING IMMUNE RESPONSE AND ANTIOXIDANT DEFENCE IN PATIENTS WITH COLORECTAL AND GASTRIC CANCER |
| title_full_unstemmed | SINGLE NUCLEOTIDE POLYMORPHISMS WITHIN GENES REGULATING IMMUNE RESPONSE AND ANTIOXIDANT DEFENCE IN PATIENTS WITH COLORECTAL AND GASTRIC CANCER |
| title_short | SINGLE NUCLEOTIDE POLYMORPHISMS WITHIN GENES REGULATING IMMUNE RESPONSE AND ANTIOXIDANT DEFENCE IN PATIENTS WITH COLORECTAL AND GASTRIC CANCER |
| title_sort | single nucleotide polymorphisms within genes regulating immune response and antioxidant defence in patients with colorectal and gastric cancer |
| topic | колоректальный рак рак желудка гены полиморфизмы генетические факторы риска |
| url | http://mednauki.ru/index.php/MK/article/view/64 |
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