Investigation of KIF6 Trp719Arg in a case-control study of myocardial infarction: a Costa Rican population.
<h4>Background and methodology</h4>The 719Arg allele of KIF6 (rs20455) was associated with coronary events in Caucasian participants of five prospective studies. We investigated whether this KIF6 variant was associated with non-fatal myocardial infarction (MI) in a case-control study of...
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Public Library of Science (PLoS)
2010-09-01
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| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0013081&type=printable |
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| author | Lance A Bare Edward A Ruiz-Narvaéz Carmen H Tong Andre R Arellano Charles M Rowland Joseph J Catanese Frank M Sacks James J Devlin Hannia Campos |
| author_facet | Lance A Bare Edward A Ruiz-Narvaéz Carmen H Tong Andre R Arellano Charles M Rowland Joseph J Catanese Frank M Sacks James J Devlin Hannia Campos |
| author_sort | Lance A Bare |
| collection | DOAJ |
| description | <h4>Background and methodology</h4>The 719Arg allele of KIF6 (rs20455) was associated with coronary events in Caucasian participants of five prospective studies. We investigated whether this KIF6 variant was associated with non-fatal myocardial infarction (MI) in a case-control study of an admixed population from the Central Valley of Costa Rica. Genotypes of the KIF6 variant were determined for 4,134 men and women. Cases (1,987) had survived a first MI; controls (2,147) had no history of MI and were matched to cases by age, sex, and area of residence. We tested the association between the KIF6 719Arg allele and non-fatal MI by conditional logistic regression and adjusted for admixture of founder populations.<h4>Principal findings</h4>Compared with the reference Trp/Trp homozygotes, KIF6 719Arg carriers were not at significantly higher risk for non-fatal MI in this study after adjustment for traditional risk factors or admixture (OR= 1.12; 95%CI, 0.98-1.28). Heterozygotes of the KIF6 Trp719Arg variant were at increased risk of non-fatal MI: the adjusted odds ratio was 1.16 (95% confidence interval, 1.01-1.34), but this association would not be significant after a multiple testing correction.<h4>Conclusions/significance</h4>We found that carriers of the KIF6 719Arg allele were not at increased risk of non-fatal MI in a case-control study of Costa Ricans living in the Central Valley of Costa Rica. |
| format | Article |
| id | doaj-art-0cac423a7d1e4f8e812e723c3fefeb3c |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2010-09-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj-art-0cac423a7d1e4f8e812e723c3fefeb3c2025-08-20T03:19:50ZengPublic Library of Science (PLoS)PLoS ONE1932-62032010-09-0159e1308110.1371/journal.pone.0013081Investigation of KIF6 Trp719Arg in a case-control study of myocardial infarction: a Costa Rican population.Lance A BareEdward A Ruiz-NarvaézCarmen H TongAndre R ArellanoCharles M RowlandJoseph J CataneseFrank M SacksJames J DevlinHannia Campos<h4>Background and methodology</h4>The 719Arg allele of KIF6 (rs20455) was associated with coronary events in Caucasian participants of five prospective studies. We investigated whether this KIF6 variant was associated with non-fatal myocardial infarction (MI) in a case-control study of an admixed population from the Central Valley of Costa Rica. Genotypes of the KIF6 variant were determined for 4,134 men and women. Cases (1,987) had survived a first MI; controls (2,147) had no history of MI and were matched to cases by age, sex, and area of residence. We tested the association between the KIF6 719Arg allele and non-fatal MI by conditional logistic regression and adjusted for admixture of founder populations.<h4>Principal findings</h4>Compared with the reference Trp/Trp homozygotes, KIF6 719Arg carriers were not at significantly higher risk for non-fatal MI in this study after adjustment for traditional risk factors or admixture (OR= 1.12; 95%CI, 0.98-1.28). Heterozygotes of the KIF6 Trp719Arg variant were at increased risk of non-fatal MI: the adjusted odds ratio was 1.16 (95% confidence interval, 1.01-1.34), but this association would not be significant after a multiple testing correction.<h4>Conclusions/significance</h4>We found that carriers of the KIF6 719Arg allele were not at increased risk of non-fatal MI in a case-control study of Costa Ricans living in the Central Valley of Costa Rica.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0013081&type=printable |
| spellingShingle | Lance A Bare Edward A Ruiz-Narvaéz Carmen H Tong Andre R Arellano Charles M Rowland Joseph J Catanese Frank M Sacks James J Devlin Hannia Campos Investigation of KIF6 Trp719Arg in a case-control study of myocardial infarction: a Costa Rican population. PLoS ONE |
| title | Investigation of KIF6 Trp719Arg in a case-control study of myocardial infarction: a Costa Rican population. |
| title_full | Investigation of KIF6 Trp719Arg in a case-control study of myocardial infarction: a Costa Rican population. |
| title_fullStr | Investigation of KIF6 Trp719Arg in a case-control study of myocardial infarction: a Costa Rican population. |
| title_full_unstemmed | Investigation of KIF6 Trp719Arg in a case-control study of myocardial infarction: a Costa Rican population. |
| title_short | Investigation of KIF6 Trp719Arg in a case-control study of myocardial infarction: a Costa Rican population. |
| title_sort | investigation of kif6 trp719arg in a case control study of myocardial infarction a costa rican population |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0013081&type=printable |
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