Single-cell analyses identify monocyte gene expression profiles that influence HIV-1 reservoir size in acutely treated cohorts

Single-cell analyses identify monocyte gene expression profiles that influence HIV-1 reservoir size in acutely treated cohorts

Abstract Eliminating latent HIV-1 is a major goal of AIDS research but host factors determining the size of these reservoirs are poorly understood. Here, we investigate the role of host gene expression on HIV-1 reservoir size during suppressive antiretroviral therapy (ART). Peripheral blood cells of...

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Main Authors: Philip K. Ehrenberg, Aviva Geretz, Meta Volcic, Taisuke Izumi, Lauren K. Yum, Adam Waickman, Shida Shangguan, Dominic Paquin-Proulx, Matthew Creegan, Meera Bose, Kawthar Machmach, Aidan McGraw, Akshara Narahari, Jeffrey R. Currier, Carlo Sacdalan, Nittaya Phanuphak, Richard Apps, Michael Corley, Lishomwa C. Ndhlovu, Bonnie Slike, Shelly J. Krebs, Jintanat Anonworanich, Sodsai Tovanabutra, Merlin L. Robb, Michael A. Eller, Gregory M. Laird, Joshua Cyktor, Eric S. Daar, Trevor A. Crowell, John W. Mellors, Sandhya Vasan, Nelson L. Michael, Frank Kirchhoff, Rasmi Thomas
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59833-9
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