<i>In vitro</i> Study of Elution Characteristics of Antiviral Drugs Immersed in Bone Cement
The objective: to assess elution characteristics of certain antiviral drugs immersed in bone cement samples and placed in a liquid medium to determine the fundamental possibility of using such systems.Subjects and Methods. For the in vitro study, dispersed ART formulation mixed with bone cement were...
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2024-12-01
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| Series: | Туберкулез и болезни лёгких |
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| Online Access: | https://www.tibl-journal.com/jour/article/view/1852 |
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| author | E. O. Peretsmanas A. A. Artyukhov I. A. Gerasimov V. S. Zubikov T. E. Tyulkova Ya. A. Rukin |
| author_facet | E. O. Peretsmanas A. A. Artyukhov I. A. Gerasimov V. S. Zubikov T. E. Tyulkova Ya. A. Rukin |
| author_sort | E. O. Peretsmanas |
| collection | DOAJ |
| description | The objective: to assess elution characteristics of certain antiviral drugs immersed in bone cement samples and placed in a liquid medium to determine the fundamental possibility of using such systems.Subjects and Methods. For the in vitro study, dispersed ART formulation mixed with bone cement were used. To study kinetics of drug elution, a spectrophotometry was used.Results. It was found out that raltegravir, emtricitabine and lamivudine possessed satisfactory thermostability and elution parameters thus allowing their use in a mixture with bone cement. The results demonstrated the fundamental possibility of developing systems with controlled release of these drugs immersed in bone cement and placed into a liquid medium. |
| format | Article |
| id | doaj-art-0c9f089d6bfa4830bdbd781178a447dc |
| institution | OA Journals |
| issn | 2075-1230 2542-1506 |
| language | Russian |
| publishDate | 2024-12-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Туберкулез и болезни лёгких |
| spelling | doaj-art-0c9f089d6bfa4830bdbd781178a447dc2025-08-20T01:47:42ZrusNew Terra Publishing HouseТуберкулез и болезни лёгких2075-12302542-15062024-12-011026667210.58838/2075-1230-2024-102-6-66-721847<i>In vitro</i> Study of Elution Characteristics of Antiviral Drugs Immersed in Bone CementE. O. Peretsmanas0A. A. Artyukhov1I. A. Gerasimov2V. S. Zubikov3T. E. Tyulkova4Ya. A. Rukin5National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of HealthMendeleev University of Chemical Technology; A.N. Nesmeyanov Institute of Organoelement Compounds of the Russian Academy of SciencesNational Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of HealthNational Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of HealthNational Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of HealthNational Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of HealthThe objective: to assess elution characteristics of certain antiviral drugs immersed in bone cement samples and placed in a liquid medium to determine the fundamental possibility of using such systems.Subjects and Methods. For the in vitro study, dispersed ART formulation mixed with bone cement were used. To study kinetics of drug elution, a spectrophotometry was used.Results. It was found out that raltegravir, emtricitabine and lamivudine possessed satisfactory thermostability and elution parameters thus allowing their use in a mixture with bone cement. The results demonstrated the fundamental possibility of developing systems with controlled release of these drugs immersed in bone cement and placed into a liquid medium.https://www.tibl-journal.com/jour/article/view/1852elutionabsorption spectraresistance to heatantiretroviral drugsbone cement |
| spellingShingle | E. O. Peretsmanas A. A. Artyukhov I. A. Gerasimov V. S. Zubikov T. E. Tyulkova Ya. A. Rukin <i>In vitro</i> Study of Elution Characteristics of Antiviral Drugs Immersed in Bone Cement Туберкулез и болезни лёгких elution absorption spectra resistance to heat antiretroviral drugs bone cement |
| title | <i>In vitro</i> Study of Elution Characteristics of Antiviral Drugs Immersed in Bone Cement |
| title_full | <i>In vitro</i> Study of Elution Characteristics of Antiviral Drugs Immersed in Bone Cement |
| title_fullStr | <i>In vitro</i> Study of Elution Characteristics of Antiviral Drugs Immersed in Bone Cement |
| title_full_unstemmed | <i>In vitro</i> Study of Elution Characteristics of Antiviral Drugs Immersed in Bone Cement |
| title_short | <i>In vitro</i> Study of Elution Characteristics of Antiviral Drugs Immersed in Bone Cement |
| title_sort | i in vitro i study of elution characteristics of antiviral drugs immersed in bone cement |
| topic | elution absorption spectra resistance to heat antiretroviral drugs bone cement |
| url | https://www.tibl-journal.com/jour/article/view/1852 |
| work_keys_str_mv | AT eoperetsmanas iinvitroistudyofelutioncharacteristicsofantiviraldrugsimmersedinbonecement AT aaartyukhov iinvitroistudyofelutioncharacteristicsofantiviraldrugsimmersedinbonecement AT iagerasimov iinvitroistudyofelutioncharacteristicsofantiviraldrugsimmersedinbonecement AT vszubikov iinvitroistudyofelutioncharacteristicsofantiviraldrugsimmersedinbonecement AT tetyulkova iinvitroistudyofelutioncharacteristicsofantiviraldrugsimmersedinbonecement AT yaarukin iinvitroistudyofelutioncharacteristicsofantiviraldrugsimmersedinbonecement |