Hair growth-promotion effects and antioxidant activity of the banana flower extract HappyAngel®: double-blind, placebo-controlled trial
Banana flowers contain various bioactive components, including several antioxidants with anti-inflammatory effects. However, it is unclear whether they can reduce and prevent hair loss. This study examines the effect of banana flower extracts on preventing hair loss and strengthening hair roots. The...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tsinghua University Press
2023-09-01
|
| Series: | Food Science and Human Wellness |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453023000435 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832546441832169472 |
|---|---|
| author | Chia-Hua Liang Yung-Hsiang Lin Yung-Kai Lin Chi-Fu Chiang |
| author_facet | Chia-Hua Liang Yung-Hsiang Lin Yung-Kai Lin Chi-Fu Chiang |
| author_sort | Chia-Hua Liang |
| collection | DOAJ |
| description | Banana flowers contain various bioactive components, including several antioxidants with anti-inflammatory effects. However, it is unclear whether they can reduce and prevent hair loss. This study examines the effect of banana flower extracts on preventing hair loss and strengthening hair roots. The banana flower extract (HappyAngel®) was used to treat human hair follicle dermal papilla cells (HFDPCs) and the expression of reactive oxygen species (ROS), dihydrotestosterone (DHT), and hair-related genes (SRD5A1, SRD5A2, AR, and KROX20) were monitored. Fifty subjects were divided into a placebo group and a banana flower group. The experimental group consumed banana flower extract daily for twelve weeks and then underwent hair testing, hair-related genes analysis, collection of hair loss, and questionnaires. The results showed that the banana flower extract significantly increased hair cell growth and decreased the expression of ROS, DHT, and hair follicle growth inhibition-related SRD5A1, SRD5A2, and AR genes, and significantly increased the expression of hair growth-related KROX20 gene in HFDPCs. Consuming banana flower extract for twelve weeks increased the hair root diameter and reduced hair loss and scalp redness compared to the placebo group. Thus, banana flower extract (HappyAngel®) can stimulate hair growth and inhibit the activation of hair loss genes. |
| format | Article |
| id | doaj-art-0c9d7b88f5044d04b1e8ab6934d0ed7e |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2023-09-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-0c9d7b88f5044d04b1e8ab6934d0ed7e2025-02-03T06:52:50ZengTsinghua University PressFood Science and Human Wellness2213-45302023-09-0112519171923Hair growth-promotion effects and antioxidant activity of the banana flower extract HappyAngel®: double-blind, placebo-controlled trialChia-Hua Liang0Yung-Hsiang Lin1Yung-Kai Lin2Chi-Fu Chiang3Department of Cosmetic Science and Institute of Cosmetic Science, Chia Nan University of Pharmacy and Science, Tainan 71710, ChinaResearch & Design Center, TCI CO., Ltd., Taipei 114722, ChinaInstitute of Food Safety and Risk Management, Department of Food Science, Taiwan Ocean University, Keelung 202301, China; Graduate Institute of Biomedical Engineering, Chung Hsing University, Taichung 202301, China; Corresponding authors.Research & Design Center, TCI CO., Ltd., Taipei 114722, China; Corresponding authors.Banana flowers contain various bioactive components, including several antioxidants with anti-inflammatory effects. However, it is unclear whether they can reduce and prevent hair loss. This study examines the effect of banana flower extracts on preventing hair loss and strengthening hair roots. The banana flower extract (HappyAngel®) was used to treat human hair follicle dermal papilla cells (HFDPCs) and the expression of reactive oxygen species (ROS), dihydrotestosterone (DHT), and hair-related genes (SRD5A1, SRD5A2, AR, and KROX20) were monitored. Fifty subjects were divided into a placebo group and a banana flower group. The experimental group consumed banana flower extract daily for twelve weeks and then underwent hair testing, hair-related genes analysis, collection of hair loss, and questionnaires. The results showed that the banana flower extract significantly increased hair cell growth and decreased the expression of ROS, DHT, and hair follicle growth inhibition-related SRD5A1, SRD5A2, and AR genes, and significantly increased the expression of hair growth-related KROX20 gene in HFDPCs. Consuming banana flower extract for twelve weeks increased the hair root diameter and reduced hair loss and scalp redness compared to the placebo group. Thus, banana flower extract (HappyAngel®) can stimulate hair growth and inhibit the activation of hair loss genes.http://www.sciencedirect.com/science/article/pii/S2213453023000435Banana flowerDihydrotestosteroneHair lossROSFollicle dermal papilla cells |
| spellingShingle | Chia-Hua Liang Yung-Hsiang Lin Yung-Kai Lin Chi-Fu Chiang Hair growth-promotion effects and antioxidant activity of the banana flower extract HappyAngel®: double-blind, placebo-controlled trial Food Science and Human Wellness Banana flower Dihydrotestosterone Hair loss ROS Follicle dermal papilla cells |
| title | Hair growth-promotion effects and antioxidant activity of the banana flower extract HappyAngel®: double-blind, placebo-controlled trial |
| title_full | Hair growth-promotion effects and antioxidant activity of the banana flower extract HappyAngel®: double-blind, placebo-controlled trial |
| title_fullStr | Hair growth-promotion effects and antioxidant activity of the banana flower extract HappyAngel®: double-blind, placebo-controlled trial |
| title_full_unstemmed | Hair growth-promotion effects and antioxidant activity of the banana flower extract HappyAngel®: double-blind, placebo-controlled trial |
| title_short | Hair growth-promotion effects and antioxidant activity of the banana flower extract HappyAngel®: double-blind, placebo-controlled trial |
| title_sort | hair growth promotion effects and antioxidant activity of the banana flower extract happyangel r double blind placebo controlled trial |
| topic | Banana flower Dihydrotestosterone Hair loss ROS Follicle dermal papilla cells |
| url | http://www.sciencedirect.com/science/article/pii/S2213453023000435 |
| work_keys_str_mv | AT chiahualiang hairgrowthpromotioneffectsandantioxidantactivityofthebananaflowerextracthappyangeldoubleblindplacebocontrolledtrial AT yunghsianglin hairgrowthpromotioneffectsandantioxidantactivityofthebananaflowerextracthappyangeldoubleblindplacebocontrolledtrial AT yungkailin hairgrowthpromotioneffectsandantioxidantactivityofthebananaflowerextracthappyangeldoubleblindplacebocontrolledtrial AT chifuchiang hairgrowthpromotioneffectsandantioxidantactivityofthebananaflowerextracthappyangeldoubleblindplacebocontrolledtrial |