Single-cell RNA sequencing reveals immune microenvironment niche transitions during the invasive and metastatic processes of ground-glass nodules and part-solid nodules in lung adenocarcinoma

Single-cell RNA sequencing reveals immune microenvironment niche transitions during the invasive and metastatic processes of ground-glass nodules and part-solid nodules in lung adenocarcinoma

Abstract Background Radiographically, ground-glass nodules (GGN) and part-solid nodules (PSN) in lung adenocarcinoma (LUAD) have significant heterogeneity in their clinical manifestations, biological characteristics, and prognosis. This study aimed to explore the heterogeneity of LUAD in different r...

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Main Authors: Yi-Feng Ren, Qiong Ma, Xiao Zeng, Chun-Xia Huang, Jia-Li Ren, Fang Li, Jia-Jing Tong, Jia-Wei He, Yang Zhong, Shi-Yan Tan, Hua Jiang, Long-Fei Zhang, Heng-Zhou Lai, Ping Xiao, Xiang Zhuang, Peng Wu, Li-Ting You, Wei Shi, Xi Fu, Chuan Zheng, Feng-Ming You
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Molecular Cancer
Subjects:
Lung adenocarcinoma
Pulmonary nodule
Tumor microenvironment
Single-cell RNA sequencing
CXCL9
TREM2
Online Access:https://doi.org/10.1186/s12943-024-02177-7
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