Antibacterial Efficacy of Moringa oleifera Leaf Extract against Salmonella typhimurium in a Rat Model: An Experimental Study on Infection Treatment
Background: The rise of antibiotic resistance has necessitated the exploration of alternative treatments, including plant-based remedies. Moringa oleifera, known for its medicinal properties, exhibits antimicrobial activity against various pathogens. This study investigates the antibacterial effic...
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College of Veterinary Medicine, University of Fallujah
2025-07-01
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| Series: | مجلة الانبار للعلوم البيطرية |
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| Online Access: | https://journals.lww.com/ajvs/_layouts/15/oaks.journals/downloadpdf.aspx?trckng_src_pg=ArticleViewer&an=02108118-202501000-00005 |
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| author | Saranraj, P |
| author_facet | Saranraj, P |
| author_sort | Saranraj, P |
| collection | DOAJ |
| description | Background: The rise of antibiotic resistance has necessitated the exploration of alternative treatments, including plant-based remedies.
Moringa oleifera, known for its medicinal properties, exhibits antimicrobial activity against various pathogens. This study investigates the
antibacterial efficacy of Moringa oleifera leaf extract against Salmonella typhimurium in a rat model. Aims and Objectives: (i) To evaluate the
antibacterial efficacy of Moringa oleifera leaf extract against Salmonella typhimurium in vivo; (ii) To assess survival rates and histopathological
changes in treated and untreated rats and (iii) To compare the efficacy of Moringa oleifera leaf extract with the standard antibiotic ciprofloxacin.
Materials and Methods: Thirty Wistar rats were divided into three groups: untreated control, positive control (ciprofloxacin-treated), and
experimental (Moringa oleifera leaf extract-treated). Rats were orally inoculated with S. typhimurium (10⁸ CFU/mL) and monitored for 14
days. Bacterial load, survival rates, and histopathological changes in liver, spleen, and intestines were analyzed. Results: The Moringa oleifera
extract significantly reduced bacterial load (from 10⁸ CFU/g to 10³ CFU/g by day 14), comparable to ciprofloxacin. Survival rates in the
experimental group (85%) were higher than the untreated control (30 %) and similar to the positive control (90 %). Histopathological analysis
revealed mild inflammation and moderate tissue damage in the treated group, contrasting with severe damage in untreated rats. Conclusion:
Moringa oleifera leaf extract demonstrated potent antibacterial activity against S. typhimurium, improving survival rates and reducing tissue
damage. Its efficacy was comparable to ciprofloxacin, suggesting its potential as a natural alternative for treating Salmonella infections |
| format | Article |
| id | doaj-art-0c978d0c51fc439cb19ffba3202bc558 |
| institution | DOAJ |
| issn | 1999-6527 2707-0603 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | College of Veterinary Medicine, University of Fallujah |
| record_format | Article |
| series | مجلة الانبار للعلوم البيطرية |
| spelling | doaj-art-0c978d0c51fc439cb19ffba3202bc5582025-08-20T03:16:28ZengCollege of Veterinary Medicine, University of Fallujahمجلة الانبار للعلوم البيطرية1999-65272707-06032025-07-011811910.4103/AJVS.AJVS_5_25Antibacterial Efficacy of Moringa oleifera Leaf Extract against Salmonella typhimurium in a Rat Model: An Experimental Study on Infection TreatmentSaranraj, P0Department of Microbiology, Sacred Heart College (Autonomous), Tirupattur, Tamil Nadu, IndiaBackground: The rise of antibiotic resistance has necessitated the exploration of alternative treatments, including plant-based remedies. Moringa oleifera, known for its medicinal properties, exhibits antimicrobial activity against various pathogens. This study investigates the antibacterial efficacy of Moringa oleifera leaf extract against Salmonella typhimurium in a rat model. Aims and Objectives: (i) To evaluate the antibacterial efficacy of Moringa oleifera leaf extract against Salmonella typhimurium in vivo; (ii) To assess survival rates and histopathological changes in treated and untreated rats and (iii) To compare the efficacy of Moringa oleifera leaf extract with the standard antibiotic ciprofloxacin. Materials and Methods: Thirty Wistar rats were divided into three groups: untreated control, positive control (ciprofloxacin-treated), and experimental (Moringa oleifera leaf extract-treated). Rats were orally inoculated with S. typhimurium (10⁸ CFU/mL) and monitored for 14 days. Bacterial load, survival rates, and histopathological changes in liver, spleen, and intestines were analyzed. Results: The Moringa oleifera extract significantly reduced bacterial load (from 10⁸ CFU/g to 10³ CFU/g by day 14), comparable to ciprofloxacin. Survival rates in the experimental group (85%) were higher than the untreated control (30 %) and similar to the positive control (90 %). Histopathological analysis revealed mild inflammation and moderate tissue damage in the treated group, contrasting with severe damage in untreated rats. Conclusion: Moringa oleifera leaf extract demonstrated potent antibacterial activity against S. typhimurium, improving survival rates and reducing tissue damage. Its efficacy was comparable to ciprofloxacin, suggesting its potential as a natural alternative for treating Salmonella infectionshttps://journals.lww.com/ajvs/_layouts/15/oaks.journals/downloadpdf.aspx?trckng_src_pg=ArticleViewer&an=02108118-202501000-00005antibacterial activitymoringa oleifera leafrat |
| spellingShingle | Saranraj, P Antibacterial Efficacy of Moringa oleifera Leaf Extract against Salmonella typhimurium in a Rat Model: An Experimental Study on Infection Treatment مجلة الانبار للعلوم البيطرية antibacterial activity moringa oleifera leaf rat |
| title | Antibacterial Efficacy of Moringa oleifera Leaf Extract against Salmonella typhimurium in a Rat Model: An Experimental Study on Infection Treatment |
| title_full | Antibacterial Efficacy of Moringa oleifera Leaf Extract against Salmonella typhimurium in a Rat Model: An Experimental Study on Infection Treatment |
| title_fullStr | Antibacterial Efficacy of Moringa oleifera Leaf Extract against Salmonella typhimurium in a Rat Model: An Experimental Study on Infection Treatment |
| title_full_unstemmed | Antibacterial Efficacy of Moringa oleifera Leaf Extract against Salmonella typhimurium in a Rat Model: An Experimental Study on Infection Treatment |
| title_short | Antibacterial Efficacy of Moringa oleifera Leaf Extract against Salmonella typhimurium in a Rat Model: An Experimental Study on Infection Treatment |
| title_sort | antibacterial efficacy of moringa oleifera leaf extract against salmonella typhimurium in a rat model an experimental study on infection treatment |
| topic | antibacterial activity moringa oleifera leaf rat |
| url | https://journals.lww.com/ajvs/_layouts/15/oaks.journals/downloadpdf.aspx?trckng_src_pg=ArticleViewer&an=02108118-202501000-00005 |
| work_keys_str_mv | AT saranrajp antibacterialefficacyofmoringaoleiferaleafextractagainstsalmonellatyphimuriuminaratmodelanexperimentalstudyoninfectiontreatment |