Antibacterial Efficacy of Moringa oleifera Leaf Extract against Salmonella typhimurium in a Rat Model: An Experimental Study on Infection Treatment
Background: The rise of antibiotic resistance has necessitated the exploration of alternative treatments, including plant-based remedies. Moringa oleifera, known for its medicinal properties, exhibits antimicrobial activity against various pathogens. This study investigates the antibacterial effic...
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| Main Author: | |
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| Format: | Article |
| Language: | English |
| Published: |
College of Veterinary Medicine, University of Fallujah
2025-07-01
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| Series: | مجلة الانبار للعلوم البيطرية |
| Subjects: | |
| Online Access: | https://journals.lww.com/ajvs/_layouts/15/oaks.journals/downloadpdf.aspx?trckng_src_pg=ArticleViewer&an=02108118-202501000-00005 |
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| Summary: | Background: The rise of antibiotic resistance has necessitated the exploration of alternative treatments, including plant-based remedies.
Moringa oleifera, known for its medicinal properties, exhibits antimicrobial activity against various pathogens. This study investigates the
antibacterial efficacy of Moringa oleifera leaf extract against Salmonella typhimurium in a rat model. Aims and Objectives: (i) To evaluate the
antibacterial efficacy of Moringa oleifera leaf extract against Salmonella typhimurium in vivo; (ii) To assess survival rates and histopathological
changes in treated and untreated rats and (iii) To compare the efficacy of Moringa oleifera leaf extract with the standard antibiotic ciprofloxacin.
Materials and Methods: Thirty Wistar rats were divided into three groups: untreated control, positive control (ciprofloxacin-treated), and
experimental (Moringa oleifera leaf extract-treated). Rats were orally inoculated with S. typhimurium (10⁸ CFU/mL) and monitored for 14
days. Bacterial load, survival rates, and histopathological changes in liver, spleen, and intestines were analyzed. Results: The Moringa oleifera
extract significantly reduced bacterial load (from 10⁸ CFU/g to 10³ CFU/g by day 14), comparable to ciprofloxacin. Survival rates in the
experimental group (85%) were higher than the untreated control (30 %) and similar to the positive control (90 %). Histopathological analysis
revealed mild inflammation and moderate tissue damage in the treated group, contrasting with severe damage in untreated rats. Conclusion:
Moringa oleifera leaf extract demonstrated potent antibacterial activity against S. typhimurium, improving survival rates and reducing tissue
damage. Its efficacy was comparable to ciprofloxacin, suggesting its potential as a natural alternative for treating Salmonella infections |
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| ISSN: | 1999-6527 2707-0603 |