Unveiling the wonders of bacteria-derived extracellular vesicles: From fundamental functions to beneficial applications
Extracellular vesicles (EVs), are critical mediators of intercellular communication and exhibit significant potential across various biomedical domains. These nano-sized, membrane-encapsulated entities have captured substantial interest due to their diverse roles in pathogenesis and promising therap...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844025008898 |
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| author | Mariam Rima Mariam Dakramanji Elie El Hayek Tia El Khoury Ziad Fajloun Mohamad Rima |
| author_facet | Mariam Rima Mariam Dakramanji Elie El Hayek Tia El Khoury Ziad Fajloun Mohamad Rima |
| author_sort | Mariam Rima |
| collection | DOAJ |
| description | Extracellular vesicles (EVs), are critical mediators of intercellular communication and exhibit significant potential across various biomedical domains. These nano-sized, membrane-encapsulated entities have captured substantial interest due to their diverse roles in pathogenesis and promising therapeutic applications. EVs manage numerous physiological processes by transferring bioactive molecules, including proteins, lipids, and nucleic acids, between cells. This review delves into the factors influencing the properties of EVs, such as temperature and stress conditions, which collectively influence their size, composition, and functional attributes. We also describe the emerging roles of EVs, emphasizing their involvement in microbial interactions, immune modulation, antimicrobial resistance spread and their potential as innovative diagnostic and therapeutic instruments. Despite their promising applications, the advancement of EV-based therapies faces several challenges, which will also be discussed. By elucidating these critical elements, we aim to provide a comprehensive overview of the transformative potential of EVs in revolutionizing diagnostics and therapeutics in medicine. |
| format | Article |
| id | doaj-art-0c93057ee44c45e7bb180fdfa1367d27 |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-0c93057ee44c45e7bb180fdfa1367d272025-02-12T05:31:24ZengElsevierHeliyon2405-84402025-02-01114e42509Unveiling the wonders of bacteria-derived extracellular vesicles: From fundamental functions to beneficial applicationsMariam Rima0Mariam Dakramanji1Elie El Hayek2Tia El Khoury3Ziad Fajloun4Mohamad Rima5Laboratory of Applied Biotechnology (LBA3B), Azm Center for Research in Biotechnology and Its Applications, EDST, Lebanese University, 1300, Tripoli, LebanonDepartment of Biological Sciences, Lebanese American University, P.O. Box 36, Byblos, LebanonDepartment of Biological Sciences, Lebanese American University, P.O. Box 36, Byblos, LebanonDepartment of Biological Sciences, Lebanese American University, P.O. Box 36, Byblos, LebanonLaboratory of Applied Biotechnology (LBA3B), Azm Center for Research in Biotechnology and Its Applications, EDST, Lebanese University, 1300, Tripoli, Lebanon; Department of Biology, Faculty of Sciences 3, Campus Michel Slayman Ras Maska, Lebanese University, 1352, Tripoli, LebanonDepartment of Biological Sciences, Lebanese American University, P.O. Box 36, Byblos, Lebanon; Corresponding author.Extracellular vesicles (EVs), are critical mediators of intercellular communication and exhibit significant potential across various biomedical domains. These nano-sized, membrane-encapsulated entities have captured substantial interest due to their diverse roles in pathogenesis and promising therapeutic applications. EVs manage numerous physiological processes by transferring bioactive molecules, including proteins, lipids, and nucleic acids, between cells. This review delves into the factors influencing the properties of EVs, such as temperature and stress conditions, which collectively influence their size, composition, and functional attributes. We also describe the emerging roles of EVs, emphasizing their involvement in microbial interactions, immune modulation, antimicrobial resistance spread and their potential as innovative diagnostic and therapeutic instruments. Despite their promising applications, the advancement of EV-based therapies faces several challenges, which will also be discussed. By elucidating these critical elements, we aim to provide a comprehensive overview of the transformative potential of EVs in revolutionizing diagnostics and therapeutics in medicine.http://www.sciencedirect.com/science/article/pii/S2405844025008898Extracellular vesiclesBiofilmAntimicrobial resistanceDrug delivery |
| spellingShingle | Mariam Rima Mariam Dakramanji Elie El Hayek Tia El Khoury Ziad Fajloun Mohamad Rima Unveiling the wonders of bacteria-derived extracellular vesicles: From fundamental functions to beneficial applications Heliyon Extracellular vesicles Biofilm Antimicrobial resistance Drug delivery |
| title | Unveiling the wonders of bacteria-derived extracellular vesicles: From fundamental functions to beneficial applications |
| title_full | Unveiling the wonders of bacteria-derived extracellular vesicles: From fundamental functions to beneficial applications |
| title_fullStr | Unveiling the wonders of bacteria-derived extracellular vesicles: From fundamental functions to beneficial applications |
| title_full_unstemmed | Unveiling the wonders of bacteria-derived extracellular vesicles: From fundamental functions to beneficial applications |
| title_short | Unveiling the wonders of bacteria-derived extracellular vesicles: From fundamental functions to beneficial applications |
| title_sort | unveiling the wonders of bacteria derived extracellular vesicles from fundamental functions to beneficial applications |
| topic | Extracellular vesicles Biofilm Antimicrobial resistance Drug delivery |
| url | http://www.sciencedirect.com/science/article/pii/S2405844025008898 |
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