Cross-kingdom regulation of plant microRNAs: potential application in crop improvement and human disease therapeutics
Plant microRNAs (miRNAs) are small non-coding RNA molecules that usually negatively regulate gene expression at the post-transcriptional level. Recent data reveal that plant miRNAs are not limited to individual plants but can transfer across different species, allowing for communication with the pla...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-12-01
|
| Series: | Frontiers in Plant Science |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpls.2024.1512047/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850063403060559872 |
|---|---|
| author | Lei Shi Lei Shi Chao Guo Miaomiao Fang Yingmei Yang Fei Yin Yuan Shen Yuan Shen |
| author_facet | Lei Shi Lei Shi Chao Guo Miaomiao Fang Yingmei Yang Fei Yin Yuan Shen Yuan Shen |
| author_sort | Lei Shi |
| collection | DOAJ |
| description | Plant microRNAs (miRNAs) are small non-coding RNA molecules that usually negatively regulate gene expression at the post-transcriptional level. Recent data reveal that plant miRNAs are not limited to individual plants but can transfer across different species, allowing for communication with the plant, animal, and microbial worlds in a cross-kingdom approach. This review discusses the differences in miRNA biosynthesis between plants and animals and summarizes the current research on the cross-species regulatory effects of plant miRNAs on nearby plants, pathogenic fungi, and insects, which can be applied to crop disease and pest resistance. In particular, this review highlights the latest findings regarding the function of plant miRNAs in the transboundary regulation of human gene expression, which may greatly expand the clinical applicability of plant miRNAs as intriguing tools in natural plant-based medicinal products in the future. |
| format | Article |
| id | doaj-art-0c92cd4776794ceea1b8833904f06ca5 |
| institution | DOAJ |
| issn | 1664-462X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Plant Science |
| spelling | doaj-art-0c92cd4776794ceea1b8833904f06ca52025-08-20T02:49:36ZengFrontiers Media S.A.Frontiers in Plant Science1664-462X2024-12-011510.3389/fpls.2024.15120471512047Cross-kingdom regulation of plant microRNAs: potential application in crop improvement and human disease therapeuticsLei Shi0Lei Shi1Chao Guo2Miaomiao Fang3Yingmei Yang4Fei Yin5Yuan Shen6Yuan Shen7International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Xinxiang Medical University, Xinxiang, ChinaSchool of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, ChinaSchool of Pharmacy, Xinxiang Medical University, Xinxiang, ChinaSchool of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, ChinaSchool of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, ChinaNational Demonstration Center for Experimental (Aquaculture) Education, School of Marine Sciences, Ningbo University, Ningbo, ChinaInternational Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Xinxiang Medical University, Xinxiang, ChinaSchool of Pharmacy, Xinxiang Medical University, Xinxiang, ChinaPlant microRNAs (miRNAs) are small non-coding RNA molecules that usually negatively regulate gene expression at the post-transcriptional level. Recent data reveal that plant miRNAs are not limited to individual plants but can transfer across different species, allowing for communication with the plant, animal, and microbial worlds in a cross-kingdom approach. This review discusses the differences in miRNA biosynthesis between plants and animals and summarizes the current research on the cross-species regulatory effects of plant miRNAs on nearby plants, pathogenic fungi, and insects, which can be applied to crop disease and pest resistance. In particular, this review highlights the latest findings regarding the function of plant miRNAs in the transboundary regulation of human gene expression, which may greatly expand the clinical applicability of plant miRNAs as intriguing tools in natural plant-based medicinal products in the future.https://www.frontiersin.org/articles/10.3389/fpls.2024.1512047/fullplant miRNAsmiRNA biosynthesiscross-kingdom regulationmiRNA transferplant-derived exosome-like nanoparticles |
| spellingShingle | Lei Shi Lei Shi Chao Guo Miaomiao Fang Yingmei Yang Fei Yin Yuan Shen Yuan Shen Cross-kingdom regulation of plant microRNAs: potential application in crop improvement and human disease therapeutics Frontiers in Plant Science plant miRNAs miRNA biosynthesis cross-kingdom regulation miRNA transfer plant-derived exosome-like nanoparticles |
| title | Cross-kingdom regulation of plant microRNAs: potential application in crop improvement and human disease therapeutics |
| title_full | Cross-kingdom regulation of plant microRNAs: potential application in crop improvement and human disease therapeutics |
| title_fullStr | Cross-kingdom regulation of plant microRNAs: potential application in crop improvement and human disease therapeutics |
| title_full_unstemmed | Cross-kingdom regulation of plant microRNAs: potential application in crop improvement and human disease therapeutics |
| title_short | Cross-kingdom regulation of plant microRNAs: potential application in crop improvement and human disease therapeutics |
| title_sort | cross kingdom regulation of plant micrornas potential application in crop improvement and human disease therapeutics |
| topic | plant miRNAs miRNA biosynthesis cross-kingdom regulation miRNA transfer plant-derived exosome-like nanoparticles |
| url | https://www.frontiersin.org/articles/10.3389/fpls.2024.1512047/full |
| work_keys_str_mv | AT leishi crosskingdomregulationofplantmicrornaspotentialapplicationincropimprovementandhumandiseasetherapeutics AT leishi crosskingdomregulationofplantmicrornaspotentialapplicationincropimprovementandhumandiseasetherapeutics AT chaoguo crosskingdomregulationofplantmicrornaspotentialapplicationincropimprovementandhumandiseasetherapeutics AT miaomiaofang crosskingdomregulationofplantmicrornaspotentialapplicationincropimprovementandhumandiseasetherapeutics AT yingmeiyang crosskingdomregulationofplantmicrornaspotentialapplicationincropimprovementandhumandiseasetherapeutics AT feiyin crosskingdomregulationofplantmicrornaspotentialapplicationincropimprovementandhumandiseasetherapeutics AT yuanshen crosskingdomregulationofplantmicrornaspotentialapplicationincropimprovementandhumandiseasetherapeutics AT yuanshen crosskingdomregulationofplantmicrornaspotentialapplicationincropimprovementandhumandiseasetherapeutics |