Vitamin D associates with improved quality of life in participants with irritable bowel syndrome: outcomes from a pilot trial
Background Vitamin D deficiency has been associated or implicated with the pathophysiology of the gastrointestinal conditions inflammatory bowel disease and colorectal cancer, as well as with depression. No trials or epidemiology studies to date have investigated a link with irritable bowel syndrome...
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BMJ Publishing Group
2015-12-01
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| Series: | BMJ Open Gastroenterology |
| Online Access: | https://bmjopengastro.bmj.com/content/2/1/e000052.full |
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| author | Sue F Plummer Iveta Garaiova Elizabeth A Williams Bernard M Corfe Simon Tazzyman Nicholas Richards Andrew R Trueman Amy L Evans Vicky A Grant |
| author_facet | Sue F Plummer Iveta Garaiova Elizabeth A Williams Bernard M Corfe Simon Tazzyman Nicholas Richards Andrew R Trueman Amy L Evans Vicky A Grant |
| author_sort | Sue F Plummer |
| collection | DOAJ |
| description | Background Vitamin D deficiency has been associated or implicated with the pathophysiology of the gastrointestinal conditions inflammatory bowel disease and colorectal cancer, as well as with depression. No trials or epidemiology studies to date have investigated a link with irritable bowel syndrome (IBS). A single case report has suggested a benefit in IBS of vitamin D supplementation. We hypothesised that IBS participants with vitamin D insufficiency would benefit from repletion in terms of their IBS symptoms. We undertook a pilot trial to provide data to support a power calculation and to justify a full trial.Methods This was a randomised, double blinded, three-arm parallel design trial of vitamin D, placebo or a combination of vitamin D and probiotics. Participants were further stratified according to whether they were vitamin D replete or insufficient. Vitamin D status was determined by blood test at baseline and exit; IBS symptoms were assessed by validated questionnaire; dietary intakes were assessed by food frequency questionnaire.Results A significant proportion of the IBS population were vitamin D deficient, such that the replete stratum could not be adequately recruited. There was a significant association in the baseline data between circulating vitamin D level and quality of life (“How much has IBS affected your life?”). Supplementation significantly improved vitamin D level versus placebo. IBS symptoms were not significantly improved in this pilot, although a power calculation was enabled from the intervention data.Conclusions The IBS population exhibits significant levels of vitamin D insufficiency and would benefit from screening and possible supplementation. The impact of IBS on quality of life may be reduced by vitamin D level. Future trials should have a sample size of over 97.Trial registration number: ICTRN 6116003917. |
| format | Article |
| id | doaj-art-0c8eeb25146548f793354c784c0f70ef |
| institution | Kabale University |
| issn | 2054-4774 |
| language | English |
| publishDate | 2015-12-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Gastroenterology |
| spelling | doaj-art-0c8eeb25146548f793354c784c0f70ef2025-02-07T16:30:14ZengBMJ Publishing GroupBMJ Open Gastroenterology2054-47742015-12-012110.1136/bmjgast-2015-000052Vitamin D associates with improved quality of life in participants with irritable bowel syndrome: outcomes from a pilot trialSue F Plummer0Iveta Garaiova1Elizabeth A Williams2Bernard M Corfe3Simon Tazzyman4Nicholas Richards5Andrew R Trueman6Amy L Evans7Vicky A Grant82 Research, Cultech Ltd, Port Talbot, UK2Research Department, Cultech Ltd, Baglan Industrial Park, Port Talbot, UK2 Department of Oncology & Metabolism, The University of Sheffield Medical School, Sheffield, UKPopulation and Health Science Institute, Newcastle University, Newcastle upon Tyne, UK1Academic Unit of Surgical Oncology, Department of Oncology, University of Sheffield, Sheffield, UK1Academic Unit of Surgical Oncology, Department of Oncology, University of Sheffield, Sheffield, UK1Academic Unit of Surgical Oncology, Department of Oncology, University of Sheffield, Sheffield, UK1Academic Unit of Surgical Oncology, Department of Oncology, University of Sheffield, Sheffield, UK1Academic Unit of Surgical Oncology, Department of Oncology, University of Sheffield, Sheffield, UKBackground Vitamin D deficiency has been associated or implicated with the pathophysiology of the gastrointestinal conditions inflammatory bowel disease and colorectal cancer, as well as with depression. No trials or epidemiology studies to date have investigated a link with irritable bowel syndrome (IBS). A single case report has suggested a benefit in IBS of vitamin D supplementation. We hypothesised that IBS participants with vitamin D insufficiency would benefit from repletion in terms of their IBS symptoms. We undertook a pilot trial to provide data to support a power calculation and to justify a full trial.Methods This was a randomised, double blinded, three-arm parallel design trial of vitamin D, placebo or a combination of vitamin D and probiotics. Participants were further stratified according to whether they were vitamin D replete or insufficient. Vitamin D status was determined by blood test at baseline and exit; IBS symptoms were assessed by validated questionnaire; dietary intakes were assessed by food frequency questionnaire.Results A significant proportion of the IBS population were vitamin D deficient, such that the replete stratum could not be adequately recruited. There was a significant association in the baseline data between circulating vitamin D level and quality of life (“How much has IBS affected your life?”). Supplementation significantly improved vitamin D level versus placebo. IBS symptoms were not significantly improved in this pilot, although a power calculation was enabled from the intervention data.Conclusions The IBS population exhibits significant levels of vitamin D insufficiency and would benefit from screening and possible supplementation. The impact of IBS on quality of life may be reduced by vitamin D level. Future trials should have a sample size of over 97.Trial registration number: ICTRN 6116003917.https://bmjopengastro.bmj.com/content/2/1/e000052.full |
| spellingShingle | Sue F Plummer Iveta Garaiova Elizabeth A Williams Bernard M Corfe Simon Tazzyman Nicholas Richards Andrew R Trueman Amy L Evans Vicky A Grant Vitamin D associates with improved quality of life in participants with irritable bowel syndrome: outcomes from a pilot trial BMJ Open Gastroenterology |
| title | Vitamin D associates with improved quality of life in participants with irritable bowel syndrome: outcomes from a pilot trial |
| title_full | Vitamin D associates with improved quality of life in participants with irritable bowel syndrome: outcomes from a pilot trial |
| title_fullStr | Vitamin D associates with improved quality of life in participants with irritable bowel syndrome: outcomes from a pilot trial |
| title_full_unstemmed | Vitamin D associates with improved quality of life in participants with irritable bowel syndrome: outcomes from a pilot trial |
| title_short | Vitamin D associates with improved quality of life in participants with irritable bowel syndrome: outcomes from a pilot trial |
| title_sort | vitamin d associates with improved quality of life in participants with irritable bowel syndrome outcomes from a pilot trial |
| url | https://bmjopengastro.bmj.com/content/2/1/e000052.full |
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