Causal Associations Between Sarcopenia and Gestational Diabetes Mellitus
Yihong Huang,1,2,* Shanshan Zhao,1,2,* Jiajun Hong,1,2 Lixia Shen,1,2 Zilian Wang,1,2 Dongyu Wang1,2 1Department of Obstetrics and Gynecology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, People’s Republic of China; 2Guangdong Provincial Clinical Research Cente...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2025-02-01
|
| Series: | International Journal of Women's Health |
| Subjects: | |
| Online Access: | https://www.dovepress.com/causal-associations-between-sarcopenia-and-gestational-diabetes-mellit-peer-reviewed-fulltext-article-IJWH |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832570251220353024 |
|---|---|
| author | Huang Y Zhao S Hong J Shen L Wang Z Wang D |
| author_facet | Huang Y Zhao S Hong J Shen L Wang Z Wang D |
| author_sort | Huang Y |
| collection | DOAJ |
| description | Yihong Huang,1,2,* Shanshan Zhao,1,2,* Jiajun Hong,1,2 Lixia Shen,1,2 Zilian Wang,1,2 Dongyu Wang1,2 1Department of Obstetrics and Gynecology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, People’s Republic of China; 2Guangdong Provincial Clinical Research Center for Obstetrical and Gynecological Diseases, Guangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Dongyu Wang; Zilian Wang, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Sun Yat-sen University, No. 58 Zhongshan Er Road, Guangzhou, People’s Republic of China, Email wangdy28@mail.sysu.edu.cn; wangzil@mail.sysu.edu.cnIntroduction: Sarcopenia may affect the onset of gestational diabetes mellitus (GDM). However, the causal relationship between sarcopenia and GDM remains unclear. In this study, we used a bi-directional Mendelian randomization (MR) approach to explore this intricate relationship.Methods: This study utilized data from FinnGen datasets and genome-wide association studies. A bi-directional MR study was conducted. First, a forward MR analysis evaluated the causality of sarcopenia on GDM risk, with sarcopenia-related traits as exposures and GDM as the outcome. Second, in the reverse MR analysis, we assessed whether GDM influenced sarcopenia-related traits. Finally, sensitivity analysis was conducted to assess the robustness of the MR analysis.Results: Forward MR analysis revealed that appendicular lean mass (odds ratio [OR] = 1.2182, 95% confidence interval [CI]: 1.1397– 1.3021, P < 0.0001), right-hand grip strength (OR= 1.4194, 95% CI: 1.0773– 1.8701, P= 0.0128), left-hand grip strength (OR= 1.6064, 95% CI: 1.2829– 2.0115, P < 0.0001), and usual walking pace (OR= 3.3676, 95% CI: 1.8769– 6.0423, P < 0.0001) were associated with an increased risk of GDM. However, according to the reverse MR results, GDM had no causal effect on sarcopenia. No pleiotropy was observed.Conclusion: In summary, sarcopenia had a significant causal influence on GDM, while GDM did not causally affect sarcopenia. Keywords: gestational diabetes mellitus, Mendelian randomization, sarcopenia, appendicular lean mass, hand grip strength, usual walking pace |
| format | Article |
| id | doaj-art-0c8def2046e64a2b8156610fca6e49ec |
| institution | Kabale University |
| issn | 1179-1411 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Women's Health |
| spelling | doaj-art-0c8def2046e64a2b8156610fca6e49ec2025-02-02T15:59:39ZengDove Medical PressInternational Journal of Women's Health1179-14112025-02-01Volume 1725926999796Causal Associations Between Sarcopenia and Gestational Diabetes MellitusHuang YZhao SHong JShen LWang ZWang DYihong Huang,1,2,* Shanshan Zhao,1,2,* Jiajun Hong,1,2 Lixia Shen,1,2 Zilian Wang,1,2 Dongyu Wang1,2 1Department of Obstetrics and Gynecology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, People’s Republic of China; 2Guangdong Provincial Clinical Research Center for Obstetrical and Gynecological Diseases, Guangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Dongyu Wang; Zilian Wang, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Sun Yat-sen University, No. 58 Zhongshan Er Road, Guangzhou, People’s Republic of China, Email wangdy28@mail.sysu.edu.cn; wangzil@mail.sysu.edu.cnIntroduction: Sarcopenia may affect the onset of gestational diabetes mellitus (GDM). However, the causal relationship between sarcopenia and GDM remains unclear. In this study, we used a bi-directional Mendelian randomization (MR) approach to explore this intricate relationship.Methods: This study utilized data from FinnGen datasets and genome-wide association studies. A bi-directional MR study was conducted. First, a forward MR analysis evaluated the causality of sarcopenia on GDM risk, with sarcopenia-related traits as exposures and GDM as the outcome. Second, in the reverse MR analysis, we assessed whether GDM influenced sarcopenia-related traits. Finally, sensitivity analysis was conducted to assess the robustness of the MR analysis.Results: Forward MR analysis revealed that appendicular lean mass (odds ratio [OR] = 1.2182, 95% confidence interval [CI]: 1.1397– 1.3021, P < 0.0001), right-hand grip strength (OR= 1.4194, 95% CI: 1.0773– 1.8701, P= 0.0128), left-hand grip strength (OR= 1.6064, 95% CI: 1.2829– 2.0115, P < 0.0001), and usual walking pace (OR= 3.3676, 95% CI: 1.8769– 6.0423, P < 0.0001) were associated with an increased risk of GDM. However, according to the reverse MR results, GDM had no causal effect on sarcopenia. No pleiotropy was observed.Conclusion: In summary, sarcopenia had a significant causal influence on GDM, while GDM did not causally affect sarcopenia. Keywords: gestational diabetes mellitus, Mendelian randomization, sarcopenia, appendicular lean mass, hand grip strength, usual walking pacehttps://www.dovepress.com/causal-associations-between-sarcopenia-and-gestational-diabetes-mellit-peer-reviewed-fulltext-article-IJWHgestational diabetes mellitusmendelian randomizationsarcopeniaappendicular lean masshand grip strengthusual walking pace |
| spellingShingle | Huang Y Zhao S Hong J Shen L Wang Z Wang D Causal Associations Between Sarcopenia and Gestational Diabetes Mellitus International Journal of Women's Health gestational diabetes mellitus mendelian randomization sarcopenia appendicular lean mass hand grip strength usual walking pace |
| title | Causal Associations Between Sarcopenia and Gestational Diabetes Mellitus |
| title_full | Causal Associations Between Sarcopenia and Gestational Diabetes Mellitus |
| title_fullStr | Causal Associations Between Sarcopenia and Gestational Diabetes Mellitus |
| title_full_unstemmed | Causal Associations Between Sarcopenia and Gestational Diabetes Mellitus |
| title_short | Causal Associations Between Sarcopenia and Gestational Diabetes Mellitus |
| title_sort | causal associations between sarcopenia and gestational diabetes mellitus |
| topic | gestational diabetes mellitus mendelian randomization sarcopenia appendicular lean mass hand grip strength usual walking pace |
| url | https://www.dovepress.com/causal-associations-between-sarcopenia-and-gestational-diabetes-mellit-peer-reviewed-fulltext-article-IJWH |
| work_keys_str_mv | AT huangy causalassociationsbetweensarcopeniaandgestationaldiabetesmellitus AT zhaos causalassociationsbetweensarcopeniaandgestationaldiabetesmellitus AT hongj causalassociationsbetweensarcopeniaandgestationaldiabetesmellitus AT shenl causalassociationsbetweensarcopeniaandgestationaldiabetesmellitus AT wangz causalassociationsbetweensarcopeniaandgestationaldiabetesmellitus AT wangd causalassociationsbetweensarcopeniaandgestationaldiabetesmellitus |