Mechanisms of T-cell Depletion in Tumors and Advances in Clinical Research
Abstract T lymphocytes (T cells) are essential components of the adaptive immune system that play a vital role in identifying and eliminating infected and tumor cells. In tumor immunotherapy, T cells have emerged as a promising therapeutic strategy due to their high specificity, potent cytotoxic cap...
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| Format: | Article |
| Language: | English |
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BMC
2025-02-01
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| Series: | Biological Procedures Online |
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| Online Access: | https://doi.org/10.1186/s12575-025-00265-6 |
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| author | Xiangfei Su Mi Zhang Hong Zhu Jingwen Cai Zhen Wang Yuewei Xu Li Wang Chen Shen Ming Cai |
| author_facet | Xiangfei Su Mi Zhang Hong Zhu Jingwen Cai Zhen Wang Yuewei Xu Li Wang Chen Shen Ming Cai |
| author_sort | Xiangfei Su |
| collection | DOAJ |
| description | Abstract T lymphocytes (T cells) are essential components of the adaptive immune system that play a vital role in identifying and eliminating infected and tumor cells. In tumor immunotherapy, T cells have emerged as a promising therapeutic strategy due to their high specificity, potent cytotoxic capability, long-lasting immune memory, and adaptability within immunotherapeutic approaches. However, tumors can evade the immune system by depleting T cells through various mechanisms, such as inhibitory receptor signaling, metabolic exhaustion, and physical barriers within the tumor microenvironment. This review provided an overview of the mechanisms underlying T-cell depletion in tumors and discussed recent advances in clinical research related to T-cell immunotherapy for tumors. It highlighted the need for in-depth studies on key issues such as indications, dosage, and sequencing of combined therapeutic strategies tailored to different patients and tumor types, providing practical guidance for individualized treatment. Future research on T-cell depletion would be necessary to uncover the fundamental mechanisms and laws of T-cell depletion, offering both theoretical insights and practical guidance for the selection and optimization of tumor immunotherapy. Furthermore, interdisciplinary, cross-disciplinary, and international collaborative innovations are necessary for developing more effective and safer treatments for tumor patients. |
| format | Article |
| id | doaj-art-0c8d7750507e47409adc7e11163f67f2 |
| institution | Kabale University |
| issn | 1480-9222 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Biological Procedures Online |
| spelling | doaj-art-0c8d7750507e47409adc7e11163f67f22025-02-09T12:12:40ZengBMCBiological Procedures Online1480-92222025-02-0127111110.1186/s12575-025-00265-6Mechanisms of T-cell Depletion in Tumors and Advances in Clinical ResearchXiangfei Su0Mi Zhang1Hong Zhu2Jingwen Cai3Zhen Wang4Yuewei Xu5Li Wang6Chen Shen7Ming Cai8China Association of Chinese MedicineDepartment of Pharmacy, The Second Affiliated Hospital of Anhui University of Chinese MedicineTongling People’s HospitalDivision of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of ChinaAnhui Provincial Children’s HospitalDepartment of Pharmacy, The Second Affiliated Hospital of Anhui University of Chinese MedicineDepartment of Pharmacy, The Second Affiliated Hospital of Anhui University of Chinese MedicineKey Laboratory of Data Science and Innovation and Development of Traditional Chinese Medicine and Social Sciences of Anhui Province, Anhui University of Chinese MedicineDepartment of Pharmacy, The Second Affiliated Hospital of Anhui University of Chinese MedicineAbstract T lymphocytes (T cells) are essential components of the adaptive immune system that play a vital role in identifying and eliminating infected and tumor cells. In tumor immunotherapy, T cells have emerged as a promising therapeutic strategy due to their high specificity, potent cytotoxic capability, long-lasting immune memory, and adaptability within immunotherapeutic approaches. However, tumors can evade the immune system by depleting T cells through various mechanisms, such as inhibitory receptor signaling, metabolic exhaustion, and physical barriers within the tumor microenvironment. This review provided an overview of the mechanisms underlying T-cell depletion in tumors and discussed recent advances in clinical research related to T-cell immunotherapy for tumors. It highlighted the need for in-depth studies on key issues such as indications, dosage, and sequencing of combined therapeutic strategies tailored to different patients and tumor types, providing practical guidance for individualized treatment. Future research on T-cell depletion would be necessary to uncover the fundamental mechanisms and laws of T-cell depletion, offering both theoretical insights and practical guidance for the selection and optimization of tumor immunotherapy. Furthermore, interdisciplinary, cross-disciplinary, and international collaborative innovations are necessary for developing more effective and safer treatments for tumor patients.https://doi.org/10.1186/s12575-025-00265-6T lymphocyteTumor immunotherapyT-cell depletionTherapeutic strategy |
| spellingShingle | Xiangfei Su Mi Zhang Hong Zhu Jingwen Cai Zhen Wang Yuewei Xu Li Wang Chen Shen Ming Cai Mechanisms of T-cell Depletion in Tumors and Advances in Clinical Research Biological Procedures Online T lymphocyte Tumor immunotherapy T-cell depletion Therapeutic strategy |
| title | Mechanisms of T-cell Depletion in Tumors and Advances in Clinical Research |
| title_full | Mechanisms of T-cell Depletion in Tumors and Advances in Clinical Research |
| title_fullStr | Mechanisms of T-cell Depletion in Tumors and Advances in Clinical Research |
| title_full_unstemmed | Mechanisms of T-cell Depletion in Tumors and Advances in Clinical Research |
| title_short | Mechanisms of T-cell Depletion in Tumors and Advances in Clinical Research |
| title_sort | mechanisms of t cell depletion in tumors and advances in clinical research |
| topic | T lymphocyte Tumor immunotherapy T-cell depletion Therapeutic strategy |
| url | https://doi.org/10.1186/s12575-025-00265-6 |
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