MAFB: a key regulator of myeloid commitment involved in hematological diseases
Abstract The MAFB protein, a member of the MAF family of bZip transcription factors, plays a pivotal role in various biological processes, including cell differentiation, development, and homeostasis. Characterized by its selective expression in monocytes and macrophages, MAFB has been shown to play...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2025-06-01
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| Series: | Cell Death Discovery |
| Online Access: | https://doi.org/10.1038/s41420-025-02551-4 |
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| _version_ | 1850102257948819456 |
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| author | Antonio Benedetto Ventura Tiziana Loconte Antonio Negri Luigi Viggiano Giuseppe Fiermonte Sabino Ciavarella Attilio Guarini Giacomo Volpe |
| author_facet | Antonio Benedetto Ventura Tiziana Loconte Antonio Negri Luigi Viggiano Giuseppe Fiermonte Sabino Ciavarella Attilio Guarini Giacomo Volpe |
| author_sort | Antonio Benedetto Ventura |
| collection | DOAJ |
| description | Abstract The MAFB protein, a member of the MAF family of bZip transcription factors, plays a pivotal role in various biological processes, including cell differentiation, development, and homeostasis. Characterized by its selective expression in monocytes and macrophages, MAFB has been shown to play a crucial role during myeloid lineage differentiation, acting as a critical determinant in the transition from multipotent progenitors to fully differentiated monocytes. By modulating the expression of genes associated with immune activation and inflammation, MAFB plays a vital role in maintaining immune homeostasis and responding to pathogenic challenges. Dysregulation of MAFB expression or function has been implicated in several pathological conditions, including hematological malignancies and metabolic disorders. In particular, aberrant MAFB activity has been associated with the progression of diseases such as multiple myeloma and acute myeloid leukemia as well as other solid tumors, where it may contribute to the survival and proliferation of malignant cells, thereby promoting disease progression. MAFB and downstream targets of its transcriptional network are now being regarded as predictive biomarkers for certain types of tumors as well as being considered as potential therapeutic targets for cancer treatment. In this review, we summarize current knowledge on both physiological and pathological roles of MAFB and highlight the impact of its deregulation on hematological cancer initiation and progression. |
| format | Article |
| id | doaj-art-0c8d2af75ed54c718280e3f234e1983e |
| institution | DOAJ |
| issn | 2058-7716 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death Discovery |
| spelling | doaj-art-0c8d2af75ed54c718280e3f234e1983e2025-08-20T02:39:48ZengNature Publishing GroupCell Death Discovery2058-77162025-06-011111910.1038/s41420-025-02551-4MAFB: a key regulator of myeloid commitment involved in hematological diseasesAntonio Benedetto Ventura0Tiziana Loconte1Antonio Negri2Luigi Viggiano3Giuseppe Fiermonte4Sabino Ciavarella5Attilio Guarini6Giacomo Volpe7Hematology and Cell Therapy Unit, IRCCS Istituto Tumori “Giovanni Paolo II”Hematology and Cell Therapy Unit, IRCCS Istituto Tumori “Giovanni Paolo II”Hematology and Cell Therapy Unit, IRCCS Istituto Tumori “Giovanni Paolo II”Department of Biology, University of Bari “Aldo Moro”Department of Bioscience, Biotechnology and Environment, University of Bari “Aldo Moro”Hematology and Cell Therapy Unit, IRCCS Istituto Tumori “Giovanni Paolo II”Hematology and Cell Therapy Unit, IRCCS Istituto Tumori “Giovanni Paolo II”Hematology and Cell Therapy Unit, IRCCS Istituto Tumori “Giovanni Paolo II”Abstract The MAFB protein, a member of the MAF family of bZip transcription factors, plays a pivotal role in various biological processes, including cell differentiation, development, and homeostasis. Characterized by its selective expression in monocytes and macrophages, MAFB has been shown to play a crucial role during myeloid lineage differentiation, acting as a critical determinant in the transition from multipotent progenitors to fully differentiated monocytes. By modulating the expression of genes associated with immune activation and inflammation, MAFB plays a vital role in maintaining immune homeostasis and responding to pathogenic challenges. Dysregulation of MAFB expression or function has been implicated in several pathological conditions, including hematological malignancies and metabolic disorders. In particular, aberrant MAFB activity has been associated with the progression of diseases such as multiple myeloma and acute myeloid leukemia as well as other solid tumors, where it may contribute to the survival and proliferation of malignant cells, thereby promoting disease progression. MAFB and downstream targets of its transcriptional network are now being regarded as predictive biomarkers for certain types of tumors as well as being considered as potential therapeutic targets for cancer treatment. In this review, we summarize current knowledge on both physiological and pathological roles of MAFB and highlight the impact of its deregulation on hematological cancer initiation and progression.https://doi.org/10.1038/s41420-025-02551-4 |
| spellingShingle | Antonio Benedetto Ventura Tiziana Loconte Antonio Negri Luigi Viggiano Giuseppe Fiermonte Sabino Ciavarella Attilio Guarini Giacomo Volpe MAFB: a key regulator of myeloid commitment involved in hematological diseases Cell Death Discovery |
| title | MAFB: a key regulator of myeloid commitment involved in hematological diseases |
| title_full | MAFB: a key regulator of myeloid commitment involved in hematological diseases |
| title_fullStr | MAFB: a key regulator of myeloid commitment involved in hematological diseases |
| title_full_unstemmed | MAFB: a key regulator of myeloid commitment involved in hematological diseases |
| title_short | MAFB: a key regulator of myeloid commitment involved in hematological diseases |
| title_sort | mafb a key regulator of myeloid commitment involved in hematological diseases |
| url | https://doi.org/10.1038/s41420-025-02551-4 |
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