Type I IFN receptor blockade alleviates liver fibrosis through macrophage-derived STAT3 signaling

Liver macrophages play a role in the development of liver fibrosis progression via the regulation of inflammatory signaling. However, the precise mechanisms of macrophages contributing to liver fibrosis progression remain unclear. Using a preclinical model of CCl4-treated mice, we determined the com...

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Bibliographic Details
Main Authors: Soo-Jeung Park, Josefina Garcia Diaz, Tina Comlekoglu, Young S. Hahn
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
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Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1528382/full
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