Overexpression of Protein Kinase C iota as a prognostic marker and its role in oxaliplatin resistance in colorectal cancer

Overexpression of Protein Kinase C iota as a prognostic marker and its role in oxaliplatin resistance in colorectal cancer

Abstract Background Protein Kinase C iota (PKCι) has been implicated in cancer progression and chemoresistance, but its prognostic significance in solid tumors remains unclear. This study aimed to evaluate the expression of PKCι in tumor tissues and its association with clinicopathological features,...

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Bibliographic Details
Main Authors: Xuankai Liao, Mengyuan Liu, Chunli Hong, Yuyan Liu, Qing Li, Ying Chen, Tingzhen Zhang, Hongda Chen, Shuying Fu
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Gastroenterology
Subjects:
PKCι
Cancer prognosis
Metastasis
Vascular invasion
Oxaliplatin resistance
Overall survival
Online Access:https://doi.org/10.1186/s12876-025-04153-x
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