Overexpression of Protein Kinase C iota as a prognostic marker and its role in oxaliplatin resistance in colorectal cancer
Abstract Background Protein Kinase C iota (PKCι) has been implicated in cancer progression and chemoresistance, but its prognostic significance in solid tumors remains unclear. This study aimed to evaluate the expression of PKCι in tumor tissues and its association with clinicopathological features,...
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BMC
2025-08-01
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| Series: | BMC Gastroenterology |
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| Online Access: | https://doi.org/10.1186/s12876-025-04153-x |
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| author | Xuankai Liao Mengyuan Liu Chunli Hong Yuyan Liu Qing Li Ying Chen Tingzhen Zhang Hongda Chen Shuying Fu |
| author_facet | Xuankai Liao Mengyuan Liu Chunli Hong Yuyan Liu Qing Li Ying Chen Tingzhen Zhang Hongda Chen Shuying Fu |
| author_sort | Xuankai Liao |
| collection | DOAJ |
| description | Abstract Background Protein Kinase C iota (PKCι) has been implicated in cancer progression and chemoresistance, but its prognostic significance in solid tumors remains unclear. This study aimed to evaluate the expression of PKCι in tumor tissues and its association with clinicopathological features, survival outcomes, and chemotherapy response in patients with cancer. Methods A retrospective analysis was conducted on patients with confirmed cancer diagnoses. Immunohistochemistry (IHC) was used to assess PKCι expression levels in tumor tissues. Kaplan-Meier survival curves and univariate Cox analysis were applied to evaluate the impact of PKCι expression and other clinicopathological variables on overall survival (OS) and progression-free survival (PFS). The association between PKCι expression and chemotherapy resistance, particularly oxaliplatin resistance, was also investigated. Results PKCι overexpression was possibly correlated with advanced clinical stage, metastasis, organs involvement, vascular invasion, and perineural invasion. Patients with PKCι overexpression was possibly correlated with oxaliplatin resistance(P = 0.014). Besides, Patients with PKCι overexpression exhibited significantly shorter PFS compared to those with low expression levels (P = 0.0006). Univariate Cox analysis confirmed that metastasis (H.R. = 11.910, P = 0.018) and clinical staging (H.R. = 5.498, P = 0.027) were independent prognostic factors for OS, whereas CEA levels (H.R. = 3.497, P = 0.005) was independent predictors of PFS. Conclusion PKCι overexpression is associated with tumor aggressiveness and chemotherapy resistance, indicating its potential as a prognostic biomarker and therapeutic target in cancer preliminarily. |
| format | Article |
| id | doaj-art-0c874415f8f04448b914c162fb12aaa3 |
| institution | Kabale University |
| issn | 1471-230X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj-art-0c874415f8f04448b914c162fb12aaa32025-08-20T04:03:02ZengBMCBMC Gastroenterology1471-230X2025-08-0125111110.1186/s12876-025-04153-xOverexpression of Protein Kinase C iota as a prognostic marker and its role in oxaliplatin resistance in colorectal cancerXuankai Liao0Mengyuan Liu1Chunli Hong2Yuyan Liu3Qing Li4Ying Chen5Tingzhen Zhang6Hongda Chen7Shuying Fu8Department of Pathology, The Seventh Affiliated Hospital, Sun Yat-sen UniversityDepartment of dermatology, The Seventh Affiliated Hospital, Sun Yat-sen UniversityDepartment of dermatology, The Seventh Affiliated Hospital, Sun Yat-sen UniversityDepartment of dermatology, The Seventh Affiliated Hospital, Sun Yat-sen UniversityDepartment of dermatology, The Seventh Affiliated Hospital, Sun Yat-sen UniversityDepartment of Traditional Chinese Medicine, Shenzhen Longhua Maternity and Child Healthcare HospitalDepartment of Pathology, The Seventh Affiliated Hospital, Sun Yat-sen UniversityDepartment of Traditional Chinese Medicine, The Seventh Affiliated Hospital, Sun Yat-sen UniversityDepartment of dermatology, The Seventh Affiliated Hospital, Sun Yat-sen UniversityAbstract Background Protein Kinase C iota (PKCι) has been implicated in cancer progression and chemoresistance, but its prognostic significance in solid tumors remains unclear. This study aimed to evaluate the expression of PKCι in tumor tissues and its association with clinicopathological features, survival outcomes, and chemotherapy response in patients with cancer. Methods A retrospective analysis was conducted on patients with confirmed cancer diagnoses. Immunohistochemistry (IHC) was used to assess PKCι expression levels in tumor tissues. Kaplan-Meier survival curves and univariate Cox analysis were applied to evaluate the impact of PKCι expression and other clinicopathological variables on overall survival (OS) and progression-free survival (PFS). The association between PKCι expression and chemotherapy resistance, particularly oxaliplatin resistance, was also investigated. Results PKCι overexpression was possibly correlated with advanced clinical stage, metastasis, organs involvement, vascular invasion, and perineural invasion. Patients with PKCι overexpression was possibly correlated with oxaliplatin resistance(P = 0.014). Besides, Patients with PKCι overexpression exhibited significantly shorter PFS compared to those with low expression levels (P = 0.0006). Univariate Cox analysis confirmed that metastasis (H.R. = 11.910, P = 0.018) and clinical staging (H.R. = 5.498, P = 0.027) were independent prognostic factors for OS, whereas CEA levels (H.R. = 3.497, P = 0.005) was independent predictors of PFS. Conclusion PKCι overexpression is associated with tumor aggressiveness and chemotherapy resistance, indicating its potential as a prognostic biomarker and therapeutic target in cancer preliminarily.https://doi.org/10.1186/s12876-025-04153-xPKCιCancer prognosisMetastasisVascular invasionOxaliplatin resistanceOverall survival |
| spellingShingle | Xuankai Liao Mengyuan Liu Chunli Hong Yuyan Liu Qing Li Ying Chen Tingzhen Zhang Hongda Chen Shuying Fu Overexpression of Protein Kinase C iota as a prognostic marker and its role in oxaliplatin resistance in colorectal cancer BMC Gastroenterology PKCι Cancer prognosis Metastasis Vascular invasion Oxaliplatin resistance Overall survival |
| title | Overexpression of Protein Kinase C iota as a prognostic marker and its role in oxaliplatin resistance in colorectal cancer |
| title_full | Overexpression of Protein Kinase C iota as a prognostic marker and its role in oxaliplatin resistance in colorectal cancer |
| title_fullStr | Overexpression of Protein Kinase C iota as a prognostic marker and its role in oxaliplatin resistance in colorectal cancer |
| title_full_unstemmed | Overexpression of Protein Kinase C iota as a prognostic marker and its role in oxaliplatin resistance in colorectal cancer |
| title_short | Overexpression of Protein Kinase C iota as a prognostic marker and its role in oxaliplatin resistance in colorectal cancer |
| title_sort | overexpression of protein kinase c iota as a prognostic marker and its role in oxaliplatin resistance in colorectal cancer |
| topic | PKCι Cancer prognosis Metastasis Vascular invasion Oxaliplatin resistance Overall survival |
| url | https://doi.org/10.1186/s12876-025-04153-x |
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