Autoantibodies Affect Brain Density Reduction in Nonneuropsychiatric Systemic Lupus Erythematosus Patients
This study explores the relationship between autoantibodies and brain density reduction in SLE patients without major neuropsychiatric manifestation (NPSLE). Ninety-five NPSLE patients without obvious cerebral deficits, as determined by conventional MRI, as well as 89 control subjects, underwent hig...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2015/920718 |
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| author | Jian Xu Yuqi Cheng Aiyun Lai Zhaoping Lv Robert A. A. Campbell Hongjun Yu Chunrong Luo Baoci Shan Lin Xu Xiufeng Xu |
| author_facet | Jian Xu Yuqi Cheng Aiyun Lai Zhaoping Lv Robert A. A. Campbell Hongjun Yu Chunrong Luo Baoci Shan Lin Xu Xiufeng Xu |
| author_sort | Jian Xu |
| collection | DOAJ |
| description | This study explores the relationship between autoantibodies and brain density reduction in SLE patients without major neuropsychiatric manifestation (NPSLE). Ninety-five NPSLE patients without obvious cerebral deficits, as determined by conventional MRI, as well as 89 control subjects, underwent high-resolution structural MRI. Whole-brain density of grey matter (GMD) and white matter (WMD) were calculated for each individual, and correlations between the brain density, symptom severity, immunosuppressive agent (ISA), and autoantibody levels were assessed. The GMD and WMD of the SLE group decreased compared to controls. GMD was negatively associated with SLE activity. The WMD of patients who received ISA treatment were higher than that in the patients who did not. The WMD of patients with anticardiolipin (ACL) or anti-SSB/La antibodies was lower than in patients without these antibodies, while the GMD was lower in patients with anti-SM or anti-U1RNP antibodies. Thus, obvious brain atrophy can occur very early even before the development of significant symptoms and specific autoantibodies might contribute to the reduction of GMD or WMD in NPSLE patients. However, ISAs showed protective effects in minimizing GMD and WMD reduction. The presence of these specific autoantibodies might help identify early brain damage in NPSLE patients. |
| format | Article |
| id | doaj-art-0c8319362dfd43b3840fb6ab4d964cd8 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-0c8319362dfd43b3840fb6ab4d964cd82025-08-20T03:54:15ZengWileyJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/920718920718Autoantibodies Affect Brain Density Reduction in Nonneuropsychiatric Systemic Lupus Erythematosus PatientsJian Xu0Yuqi Cheng1Aiyun Lai2Zhaoping Lv3Robert A. A. Campbell4Hongjun Yu5Chunrong Luo6Baoci Shan7Lin Xu8Xiufeng Xu9Department of Rheumatology and Immunology, First Affiliated Hospital of Kunming Medical University, Kunming 650032, ChinaDepartment of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming 650032, ChinaDepartment of Rheumatology and Immunology, First Affiliated Hospital of Kunming Medical University, Kunming 650032, ChinaDepartment of Rheumatology and Immunology, First Affiliated Hospital of Kunming Medical University, Kunming 650032, ChinaDepartment of Neuroscience, Cold Spring Harbor Laboratory, New York, NY 11724, USAMagnetic Resonance Imaging Center, First Hospital of Kunming City, Kunming 650011, ChinaMagnetic Resonance Imaging Center, First Hospital of Kunming City, Kunming 650011, ChinaKey Laboratory of Nuclear Analysis, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, ChinaKey Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences, Kunming 650223, ChinaDepartment of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming 650032, ChinaThis study explores the relationship between autoantibodies and brain density reduction in SLE patients without major neuropsychiatric manifestation (NPSLE). Ninety-five NPSLE patients without obvious cerebral deficits, as determined by conventional MRI, as well as 89 control subjects, underwent high-resolution structural MRI. Whole-brain density of grey matter (GMD) and white matter (WMD) were calculated for each individual, and correlations between the brain density, symptom severity, immunosuppressive agent (ISA), and autoantibody levels were assessed. The GMD and WMD of the SLE group decreased compared to controls. GMD was negatively associated with SLE activity. The WMD of patients who received ISA treatment were higher than that in the patients who did not. The WMD of patients with anticardiolipin (ACL) or anti-SSB/La antibodies was lower than in patients without these antibodies, while the GMD was lower in patients with anti-SM or anti-U1RNP antibodies. Thus, obvious brain atrophy can occur very early even before the development of significant symptoms and specific autoantibodies might contribute to the reduction of GMD or WMD in NPSLE patients. However, ISAs showed protective effects in minimizing GMD and WMD reduction. The presence of these specific autoantibodies might help identify early brain damage in NPSLE patients.http://dx.doi.org/10.1155/2015/920718 |
| spellingShingle | Jian Xu Yuqi Cheng Aiyun Lai Zhaoping Lv Robert A. A. Campbell Hongjun Yu Chunrong Luo Baoci Shan Lin Xu Xiufeng Xu Autoantibodies Affect Brain Density Reduction in Nonneuropsychiatric Systemic Lupus Erythematosus Patients Journal of Immunology Research |
| title | Autoantibodies Affect Brain Density Reduction in Nonneuropsychiatric Systemic Lupus Erythematosus Patients |
| title_full | Autoantibodies Affect Brain Density Reduction in Nonneuropsychiatric Systemic Lupus Erythematosus Patients |
| title_fullStr | Autoantibodies Affect Brain Density Reduction in Nonneuropsychiatric Systemic Lupus Erythematosus Patients |
| title_full_unstemmed | Autoantibodies Affect Brain Density Reduction in Nonneuropsychiatric Systemic Lupus Erythematosus Patients |
| title_short | Autoantibodies Affect Brain Density Reduction in Nonneuropsychiatric Systemic Lupus Erythematosus Patients |
| title_sort | autoantibodies affect brain density reduction in nonneuropsychiatric systemic lupus erythematosus patients |
| url | http://dx.doi.org/10.1155/2015/920718 |
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