T-follicular helper cells are epigenetically poised to transdifferentiate into T-regulatory type 1 cells

T-follicular helper cells are epigenetically poised to transdifferentiate into T-regulatory type 1 cells

Chronic antigenic stimulation can trigger the formation of interleukin 10 (IL-10)-producing T-regulatory type 1 (TR1) cells in vivo. We have recently shown that murine T-follicular helper (TFH) cells are precursors of TR1 cells and that the TFH-to-TR1 cell transdifferentiation process is characteriz...

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Bibliographic Details
Main Authors: Josep Garnica, Patricia Sole, Jun Yamanouchi, Joel Moro, Debajyoti Mondal, Cesar Fandos, Pau Serra, Pere Santamaria
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-11-01
Series:eLife
Subjects:
T-regulatory type 1 cells
TR1 cells
T-follicular helper cells
TFH cells
transdifferentiation
epigenetics
Online Access:https://elifesciences.org/articles/97665
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