Pancreatic β-cell regeneration in situ by the ALK3 agonist THR-123

Pancreatic β-cell regeneration in situ by the ALK3 agonist THR-123

Abstract The demonstration that BMP signaling activates progenitor-like populations within pancreatic ducts supports the potential use of BMP receptor agonists to induce islet neogenesis in situ. In this context, we tested the ability of THR-123, a cyclic peptide with BMP-7-like activity, to regener...

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Main Authors: Silvia Álvarez-Cubela, Isabella D. Altilio, Mayur Doke, Dagmar Klein, Alejandro Tamayo, Óscar Alcázar, Carlos García Santana, Mirza Muhammad Fahd Qadir, Charles García Alver, Francis Cruz, Olivia Biggs, Jorge David Tovar Castro, Belén Navarro-Rubio, Camillo Ricordi, Alejandro Caicedo, Peter Buchwald, Ashutosh Agarwal, Elisa Oltra, Ricardo Luis Pastori, Juan Domínguez-Bendala
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61534-2
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