Predictors of patients with advanced pancreatic cancer undergoing conversion surgery via chemoimmunotherapy with a multifunctional Wilms’ tumor 1 (WT1) peptide cocktail-pulsed dendritic cell vaccine

Predictors of patients with advanced pancreatic cancer undergoing conversion surgery via chemoimmunotherapy with a multifunctional Wilms’ tumor 1 (WT1) peptide cocktail-pulsed dendritic cell vaccine

Background A chemoimmunotherapy regimen consisting of a novel Wilms’ tumor 1 (WT1) peptide-pulsed dendritic cell (WT1-DC) vaccine and multiagent chemotherapy was observed to modulate the tumor microenvironment (TME) to an immunostimulatory state, resulting in conversion surgery in seven out of nine...

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Main Authors: Nobuhiro Sato, Shigetaka Shimodaira, Masayuki Saruta, Yoko Shimizu, Shigeo Koido, Junichi Taguchi, Masamori Shimabuku, Tuuse Bito, Zensho Ito, Kan Uchiyama, Toshifumi Ohkusa, Haruo Sugiyama, Soyoko Morimoto, Yusuke Oji, Yoshihiro Oka, Masaki Ito
Format: Article
Language:English
Published: BMJ Publishing Group 2025-07-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/13/7/e011426.full
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