Unraveling the liver metabolomic profile of ADB-BUTINACA-induced hepatotoxicity

ADB-BUTINACA, as a new psychoactive substance, can induce physical and psychological dependence. However, the systemic biological impact of ADB-BUTINACA on hepatic metabolomics remains uncertain. The metabolic spectrum in rat livers following exposure to three varying doses of ADB-BUTINACA (0.1, 1,...

Full description

Saved in:

Bibliographic Details
Main Authors:	Yilei Fan, Yingyu Huang, Yi Zhou, Xing Ke, Yimei Tian, Siyue Zheng, Yang Sun, Zhongping Huang, Jing Zhou, Li Wu
Format:	Article
Language:	English
Published:	Elsevier 2024-12-01
Series:	Ecotoxicology and Environmental Safety
Subjects:	ADB-BUTINACA Non-targeted metabolomics Multivariate statistical analysis UHPLC-Q-Orbitrap-HRMS Molecular Docking Hepatotoxicity
Online Access:	http://www.sciencedirect.com/science/article/pii/S0147651324014519
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Evaluation of in-vitro and in-silico antidiabetic potential, glucose metabolism, antioxidant, cytotoxicity and phytochemical content of Ipomoea bolusiana Schinz and Ipomoea crassipes Hook tubers
by: Garland Kgosi More, et al.
Published: (2025-02-01)

Implementation of FTIR-Based Fingerprinting, Antioxidant Compounds Profiling by UHPLC-Q-Orbitrap HRMS, and Docking Study COVID-19 Inhibitor of Buas-Buas (Premna serratifolia) Leaf Extract from Pontianak Indonesia
by: Dini Hadiarti, et al.
Published: (2025-03-01)

Effect of Cooking and <i>in vitro</i> Digestion on the Polyphenols and Antioxidant Properties of <i>Asparagus officinalis</i> L. cultivars
by: Angela Di Matteo, et al.
Published: (2025-07-01)

Toxicological effects of ADB-FUBINACA on early zebrafish development: An analysis utilizing metabolomics
by: Yang Luo, et al.
Published: (2025-09-01)

Multipolarity in Development Banking: The Asian Infrastructure & Investment Bank (AIIB) and Asian Development Bank (ADB)
by: Yeremia Nicolaus Widjanarko
Published: (2024-12-01)

Simultaneous determination of 7 thiols associated proteins in lymphoma patients’serum and cerebrospinal fluid by UHPLC-HRMS technique
by: Qingkun Ma, et al.
Published: (2025-07-01)

Detection of ADB-4en-PINACA metabolite in the authentic urine samples
by: Ching Yee Fong, et al.
Published: (2024-12-01)

Mechanism Exploration of Dunyeguanxinning in the Treatment of Atherosclerosis Based on UPLC-Q-Orbitrap HRMS Technology, Network Pharmacology, Molecular Docking and Experimental Validation
by: Wang D, et al.
Published: (2025-04-01)

Interference of endogenous benzoic acid with the signatures of sulfonic acid derivatives and carbohydrates in fermented dairy products
by: Wei Jia, et al.
Published: (2024-11-01)

Untargeted metabolomics profiling for the geographical authentication of traditional pempek using high-resolution orbitrap mass spectrometry
by: Agus Supriadi, et al.
Published: (2025-03-01)

Metabolomics and lipidomics of plasma biomarkers for tuberculosis diagnostics using UHPLC-HRMS
by: Gaofeng Sun, et al.
Published: (2025-06-01)

Unraveling DINCH – Induced hepatotoxicity mechanisms via network toxicology and molecular docking with experimental validation
by: Jingxin Xin, et al.
Published: (2025-07-01)

Toxicological Assessment of Ketamine in Juvenile Zebrafish (<i>Danio rerio</i>)
by: Yin Tang, et al.
Published: (2025-01-01)

Evaluation of Untargeted Metabolomic and Mycotoxin Profiles in Corn Silage and High-Moisture Corn
by: Marco Lapris, et al.
Published: (2025-04-01)

Differential Effects of Non-Microbial Biostimulants on Secondary Metabolites and Nitrate Content in Organic Arugula Leaves
by: Michele Ciriello, et al.
Published: (2025-07-01)

Subacute Toxicity and Pharmacokinetic Evaluation of the Synthetic Cannabinoid 4F-MDMB-BUTINACA in Rats: A Forensic and Toxicological Perspective
by: Elkhatim Hassan Abdelgadir, et al.
Published: (2024-10-01)

Comprehensive analysis of histophysiology, transcriptomics and metabolomics in goslings exposed to gossypol acetate: unraveling hepatotoxic mechanisms
by: Jun Yu, et al.
Published: (2025-01-01)

Untargeted Metabolomics Reveals Distinct Anthocyanin Profiles in Napier Grass (<i>Pennisetum purpureum</i> Schumach.) Cultivars
by: Zhi-Yue Wang, et al.
Published: (2025-07-01)

Studying chemical signals in plant–soil mesofauna interactions
by: Bohm, Victoria, et al.
Published: (2024-01-01)

Molecular Characterization of Organic Aerosol in Summer Suburban Shanghai Under High Humidity
by: Xiancheng Tang, et al.
Published: (2025-05-01)

Metabolomic profiling in a rat model of visual fatigue associated with liver-kidney yin deficiency syndrome
by: Xue Zhang, et al.
Published: (2025-07-01)

Identification of Bioactive Metabolites of <i>Capirona macrophylla</i> by Metabolomic Analysis, Molecular Docking, and In Vitro Antiparasitic Assays
by: Joseph Evaristo, et al.
Published: (2025-02-01)

Non-Targeted Lipidomics Analysis of Characteristic Milk Using High-Resolution Mass Spectrometry (UHPLC-HRMS)
by: Tingting Wei, et al.
Published: (2025-06-01)

Phytochemical profiling, antioxidant potential, and UHPLC-HRMS analysis of Phlomis genus aerial parts for therapeutic applications
by: Seyyed Ali Gheibi, et al.
Published: (2025-02-01)

Screening of native wild Salvia nemorosa populations for chemical compositions, antioxidant activity and UHPLC-HRMS profiling
by: Raheleh Moshari-Nasirkandi, et al.
Published: (2024-12-01)

Grape Seed Powders as a Source of Phenolic Compounds: UHPLC Orbitrap MS4 Characterization
by: Danijel D. Milinčić, et al.
Published: (2024-02-01)

A Systematic Methodology for the Identification of the Chemical Composition of the Mongolian Drug Erdun-Uril Compound Utilizing UHPLC-Q-Exactive Orbitrap Mass Spectrometry
by: Yanghui Huo, et al.
Published: (2024-09-01)

Protective effects and metabolomics analysis of dihydromyricetin on cyclophosphamide-induced hepatotoxicity in mice
by: Fei Teng, et al.
Published: (2025-12-01)

Trema micranthum (L.) Blume as a new source of cannabinoids
by: Rayssa Ribeiro, et al.
Published: (2024-11-01)

New Insights into the Metabolic Profile and Cytotoxic Activity of <i>Kigelia africana</i> Stem Bark
by: Dimitrina Zheleva-Dimitrova, et al.
Published: (2025-03-01)

Unveiling the anticancer potential of Curcuma amada rhizome extract against prostate cancer through computational and experimental approaches
by: Arpita Priyadarshini, et al.
Published: (2025-07-01)

Detection of pharmaceuticals and their transformation products in seawaters using off-line solid phase extraction and liquid chromatography-high resolution mass spectrometry
by: Aggeliki Kalogeropoulou, et al.
Published: (2024-11-01)

Uncovering mechanism of hepatotoxicity diseases caused by tetrahydrocannabinol based on novel network toxicology and experimental verification
by: Tiantian Zou, et al.
Published: (2025-04-01)

Comparing the Metabolic Characteristics of Hyacinth Bean (<i>Lablab purpureus</i> L.) Seeds from Five Local Varieties by UHPLC-QE HF HRMS
by: Li Yu, et al.
Published: (2025-05-01)

Pulsed Electric Field Induces Significant Changes in the Metabolome of <i>Fusarium</i> Species and Decreases Their Viability and Toxigenicity
by: Adam Behner, et al.
Published: (2025-01-01)

Mass spectrometry-based metabolomics reveal the effects and potential mechanism of isochlorogenic acid A in MC3T3-E1 cells
by: Lian Zhu, et al.
Published: (2025-03-01)

A novel UHPLC-HRMS method for simultaneous determination of 20 amino metabolites and proteins in lymphoma patients’ cells and serum
by: Mei Zhang, et al.
Published: (2025-07-01)

Salvadora persica leaves: phytochemical profile and in vitro-inhibitory activity on inflammatory mediators implicated in periodontal disease
by: Sabine Kobetitsch, et al.
Published: (2024-12-01)

Flavonoid compound from Forsythia suspensa leaves inhibits adenovirus infection related to cell cycle based on UHPLC-Q-Exactive-Orbitrap/MS and experimental validation
by: Lingling Wang, et al.
Published: (2025-08-01)

Hormetic effect of UV-C radiation on red mustard microgreens growth and chemical composition
by: Marta Silva, et al.
Published: (2024-12-01)