Serum Interleukin-6 Expression Level and Its Clinical Significance in Patients with Dermatomyositis
Objective. To analyze serum interleukin-6 (IL-6) expression level and its clinical significance in patients with dermatomyositis. Methods. Blood samples from 23 adult patients with dermatomyositis (DM), 22 with systemic lupus erythematosus (SLE), 22 with rheumatoid arthritis (RA), 16 with Sjögren�...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/717808 |
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| author | Min Yang Xiaomin Cen Qibing Xie Chuan Zuo Guixiu Shi Geng Yin |
| author_facet | Min Yang Xiaomin Cen Qibing Xie Chuan Zuo Guixiu Shi Geng Yin |
| author_sort | Min Yang |
| collection | DOAJ |
| description | Objective. To analyze serum interleukin-6 (IL-6) expression level and its clinical significance in patients with dermatomyositis. Methods. Blood samples from 23 adult patients with dermatomyositis (DM), 22 with systemic lupus erythematosus (SLE), 22 with rheumatoid arthritis (RA), 16 with Sjögren's syndrome (SS), and 20 healthy controls were collected. The IL-6 concentration was detected by chemiluminescence immunoassay. Correlations between IL-6 expression levels and clinical features or laboratory findings in patients with DM were investigated. Results. IL-6 expression level of DM patients was significantly higher than that of normal controls, significantly lower than that of RA patients, and slightly lower than that of SLE or SS patients with no significant differences. The incidence of fever was significantly higher in the IL-6 elevated group. Serum ferritin (SF) and C-reactive protein (CRP) were positively correlated with IL-6. Conclusions. IL-6 plays a less important role in DM than in RA. IL-6 monoclonal antibodies may have poor effect in patients with DM. |
| format | Article |
| id | doaj-art-0c6e769b36af481a913208cd253eb648 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-0c6e769b36af481a913208cd253eb6482025-02-03T00:59:47ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/717808717808Serum Interleukin-6 Expression Level and Its Clinical Significance in Patients with DermatomyositisMin Yang0Xiaomin Cen1Qibing Xie2Chuan Zuo3Guixiu Shi4Geng Yin5Department of Rheumatology and Immunology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, ChinaDepartment of Rheumatology and Immunology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, ChinaDepartment of Rheumatology and Immunology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, ChinaDepartment of Rheumatology and Immunology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, ChinaDepartment of Rheumatology and Immunology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, ChinaDepartment of Rheumatology and Immunology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, ChinaObjective. To analyze serum interleukin-6 (IL-6) expression level and its clinical significance in patients with dermatomyositis. Methods. Blood samples from 23 adult patients with dermatomyositis (DM), 22 with systemic lupus erythematosus (SLE), 22 with rheumatoid arthritis (RA), 16 with Sjögren's syndrome (SS), and 20 healthy controls were collected. The IL-6 concentration was detected by chemiluminescence immunoassay. Correlations between IL-6 expression levels and clinical features or laboratory findings in patients with DM were investigated. Results. IL-6 expression level of DM patients was significantly higher than that of normal controls, significantly lower than that of RA patients, and slightly lower than that of SLE or SS patients with no significant differences. The incidence of fever was significantly higher in the IL-6 elevated group. Serum ferritin (SF) and C-reactive protein (CRP) were positively correlated with IL-6. Conclusions. IL-6 plays a less important role in DM than in RA. IL-6 monoclonal antibodies may have poor effect in patients with DM.http://dx.doi.org/10.1155/2013/717808 |
| spellingShingle | Min Yang Xiaomin Cen Qibing Xie Chuan Zuo Guixiu Shi Geng Yin Serum Interleukin-6 Expression Level and Its Clinical Significance in Patients with Dermatomyositis Clinical and Developmental Immunology |
| title | Serum Interleukin-6 Expression Level and Its Clinical Significance in Patients with Dermatomyositis |
| title_full | Serum Interleukin-6 Expression Level and Its Clinical Significance in Patients with Dermatomyositis |
| title_fullStr | Serum Interleukin-6 Expression Level and Its Clinical Significance in Patients with Dermatomyositis |
| title_full_unstemmed | Serum Interleukin-6 Expression Level and Its Clinical Significance in Patients with Dermatomyositis |
| title_short | Serum Interleukin-6 Expression Level and Its Clinical Significance in Patients with Dermatomyositis |
| title_sort | serum interleukin 6 expression level and its clinical significance in patients with dermatomyositis |
| url | http://dx.doi.org/10.1155/2013/717808 |
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