Right ventricular outflow tract morphology and its clinical significance for invasive procedures
Abstract We aimed to evaluate in detail the right ventricular outflow tract (RVOT) morphology to enhance clinical procedures performed within this area. Two hundred twenty autopsied adult human hearts (37.2% females, 47.6 ± 18.0 years old) without macrostructural cardiac abnormalities were examined....
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Nature Portfolio
2025-07-01
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| Online Access: | https://doi.org/10.1038/s41598-025-06663-w |
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| author | Marcin Jakiel Rafał Jakiel Jakub Batko Edyta Dyngosz Maria Kurek Karolina Gutkowska Jakub Hołda Filip Bolechała Marcin Strona Mateusz K. Hołda |
| author_facet | Marcin Jakiel Rafał Jakiel Jakub Batko Edyta Dyngosz Maria Kurek Karolina Gutkowska Jakub Hołda Filip Bolechała Marcin Strona Mateusz K. Hołda |
| author_sort | Marcin Jakiel |
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| description | Abstract We aimed to evaluate in detail the right ventricular outflow tract (RVOT) morphology to enhance clinical procedures performed within this area. Two hundred twenty autopsied adult human hearts (37.2% females, 47.6 ± 18.0 years old) without macrostructural cardiac abnormalities were examined. The RVOT was macroscopically and morphometrically evaluated. The RVOT has a truncated cone shape with the elliptical RVOT base being significantly larger than its distal boundary (pulmonary root basal ring) (mean perimeter: 126.6 ± 27.7 vs. 73.2 ± 11.6 mm, p < 0.001). The right RVOT wall is the highest (30.5 ± 6.1 mm), followed by the anterior (29.4 ± 7.3 mm), left (27.3 ± 6.4 mm), and posterior (26.9 ± 6.5 mm). The RVOT may be divided into the free-standing thin-walled subpulmonary infundibulum and the septal component, which constitutes a significant portion of the RVOT posterior wall (37.3 ± 13.8%). The RVOT wall thickness demonstrated significant differences among the respective RVOT walls and across the RVOT levels. The length of the supraventricular crest is 29.1 ± 6.9 mm, and it narrows along its course (thickness at origin: 12.26 ± 2.9 mm vs. at termination: 9.2 ± 1.9 mm, p < 0.001). The length of the septoparietal band is 16.6 ± 3.9 mm, and its thickness remains relatively constant along its entire length (at origin: 6.9 ± 1.6 mm, at termination: 7.2 ± 2.4 mm, p = 0.124). Endocardial roughness of the RVOT, such as trabeculations, recesses, or muscular bridges, are present in all hearts within the subpulmonary infundibulum and in only 8.2% of the septal component. No significant differences between sexes were found in any of the measured RVOT parameters. In conclusion, this study provides a detailed definition, along with anatomical and structural analysis of the RVOT, highlighting its complex morphology and its significant role in cardiac functionality and clinical interventions. |
| format | Article |
| id | doaj-art-0c69ec00616745d4b360c044c197b3a0 |
| institution | Kabale University |
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| spelling | doaj-art-0c69ec00616745d4b360c044c197b3a02025-08-20T04:03:03ZengNature PortfolioScientific Reports2045-23222025-07-0115111510.1038/s41598-025-06663-wRight ventricular outflow tract morphology and its clinical significance for invasive proceduresMarcin Jakiel0Rafał Jakiel1Jakub Batko2Edyta Dyngosz3Maria Kurek4Karolina Gutkowska5Jakub Hołda6Filip Bolechała7Marcin Strona8Mateusz K. Hołda9HEART – Heart Embryology and Anatomy Research Team, Department of Anatomy, Jagiellonian University Medical CollegeHEART – Heart Embryology and Anatomy Research Team, Department of Anatomy, Jagiellonian University Medical CollegeHEART – Heart Embryology and Anatomy Research Team, Department of Anatomy, Jagiellonian University Medical CollegeHEART – Heart Embryology and Anatomy Research Team, Department of Anatomy, Jagiellonian University Medical CollegeHEART – Heart Embryology and Anatomy Research Team, Department of Anatomy, Jagiellonian University Medical CollegeHEART – Heart Embryology and Anatomy Research Team, Department of Anatomy, Jagiellonian University Medical CollegeHEART – Heart Embryology and Anatomy Research Team, Department of Anatomy, Jagiellonian University Medical CollegeDepartment of Forensic Medicine, Jagiellonian University Medical CollegeDepartment of Forensic Medicine, Jagiellonian University Medical CollegeHEART – Heart Embryology and Anatomy Research Team, Department of Anatomy, Jagiellonian University Medical CollegeAbstract We aimed to evaluate in detail the right ventricular outflow tract (RVOT) morphology to enhance clinical procedures performed within this area. Two hundred twenty autopsied adult human hearts (37.2% females, 47.6 ± 18.0 years old) without macrostructural cardiac abnormalities were examined. The RVOT was macroscopically and morphometrically evaluated. The RVOT has a truncated cone shape with the elliptical RVOT base being significantly larger than its distal boundary (pulmonary root basal ring) (mean perimeter: 126.6 ± 27.7 vs. 73.2 ± 11.6 mm, p < 0.001). The right RVOT wall is the highest (30.5 ± 6.1 mm), followed by the anterior (29.4 ± 7.3 mm), left (27.3 ± 6.4 mm), and posterior (26.9 ± 6.5 mm). The RVOT may be divided into the free-standing thin-walled subpulmonary infundibulum and the septal component, which constitutes a significant portion of the RVOT posterior wall (37.3 ± 13.8%). The RVOT wall thickness demonstrated significant differences among the respective RVOT walls and across the RVOT levels. The length of the supraventricular crest is 29.1 ± 6.9 mm, and it narrows along its course (thickness at origin: 12.26 ± 2.9 mm vs. at termination: 9.2 ± 1.9 mm, p < 0.001). The length of the septoparietal band is 16.6 ± 3.9 mm, and its thickness remains relatively constant along its entire length (at origin: 6.9 ± 1.6 mm, at termination: 7.2 ± 2.4 mm, p = 0.124). Endocardial roughness of the RVOT, such as trabeculations, recesses, or muscular bridges, are present in all hearts within the subpulmonary infundibulum and in only 8.2% of the septal component. No significant differences between sexes were found in any of the measured RVOT parameters. In conclusion, this study provides a detailed definition, along with anatomical and structural analysis of the RVOT, highlighting its complex morphology and its significant role in cardiac functionality and clinical interventions.https://doi.org/10.1038/s41598-025-06663-wRight ventricular outflow trackRight ventricleRVOT septal componentSubpulmonary infundibulumPulmonary rootSupraventricular crest |
| spellingShingle | Marcin Jakiel Rafał Jakiel Jakub Batko Edyta Dyngosz Maria Kurek Karolina Gutkowska Jakub Hołda Filip Bolechała Marcin Strona Mateusz K. Hołda Right ventricular outflow tract morphology and its clinical significance for invasive procedures Scientific Reports Right ventricular outflow track Right ventricle RVOT septal component Subpulmonary infundibulum Pulmonary root Supraventricular crest |
| title | Right ventricular outflow tract morphology and its clinical significance for invasive procedures |
| title_full | Right ventricular outflow tract morphology and its clinical significance for invasive procedures |
| title_fullStr | Right ventricular outflow tract morphology and its clinical significance for invasive procedures |
| title_full_unstemmed | Right ventricular outflow tract morphology and its clinical significance for invasive procedures |
| title_short | Right ventricular outflow tract morphology and its clinical significance for invasive procedures |
| title_sort | right ventricular outflow tract morphology and its clinical significance for invasive procedures |
| topic | Right ventricular outflow track Right ventricle RVOT septal component Subpulmonary infundibulum Pulmonary root Supraventricular crest |
| url | https://doi.org/10.1038/s41598-025-06663-w |
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