Prognostic Role of Basophils to Predict Major Adverse Cardiac Cerebrovascular Events in ST Elevation Myocardial Infarction Patients: Egyptian PCI-Capable Center Experience
Abstract Background Previous studies have shown that inflammation and immune cells play a critical role in acute ST elevation myocardial infarction (STEMI). Little is known about association of basophils and major adverse cardiac cerebrovascular events (MACCE) in STEMI. Aim of the study To evaluate...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Springer
2021-12-01
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| Series: | Egyptian Journal of Critical Care Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1097/EJ9.0000000000000033 |
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| Summary: | Abstract Background Previous studies have shown that inflammation and immune cells play a critical role in acute ST elevation myocardial infarction (STEMI). Little is known about association of basophils and major adverse cardiac cerebrovascular events (MACCE) in STEMI. Aim of the study To evaluate the association between basophil counts and in-hospital MACCE in STEMI patients. Methods A retrospective analysis was conducted on 607 STEMI patients. Routine laboratory tests including complete blood picture on admission and 24 hours later. In-hospital MACCE were recorded. Results The mean age was 57.7 ±11.3 (488 male patients). Length of hospital stay was 6.5 ±5.0 days. Patients who developed MACCEs were 79 (13%) with mortality (11%) Patients who experienced MACCE, had higher absolute basophil count on admission (1052.3±1237.4 versus 466.0±587.3, P < 70%), total leucocytic count within 1st 24 hours, basophilic counts on admission and within 1st 24 hours, contrast-induced nephropathy and need for organ support measures were potential significant predictors for MACCE. Absolute basophilic count on admission cutoff (370.0/mm3) showed area under curve 0.71, sensitivity of 68.4% and specificity of 63.6% for predicting MACCE. Absolute basophilic count within 1st 24 hours cutoff (350.0/mm3) showed area under curve 0.763, sensitivity of 73.4% and specificity of 68.7% for predicting MACCE. Conclusion Basophilic counts on admission and 24 hours later were higher in MACCE group and could provide acceptable cutoffs for predicting in-hospital MACCE. Trial registration Study ID ISRCTN17329623. |
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| ISSN: | 2090-7303 2090-9209 |