Improving Islet Engraftment by Gene Therapy
Islet cell transplantation is currently the only feasible long-term treatment option for patients with type 1 diabetes. However, the majority of transplanted islets experience damage and apoptosis during the isolation process, a blood-mediated inflammatory microenvironment in the portal vein upon is...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
|
| Series: | Journal of Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2011/594851 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849308999519830016 |
|---|---|
| author | Xiaojie Wang Mark Meloche C. Bruce Verchere Dawei Ou Alice Mui Garth L. Warnock |
| author_facet | Xiaojie Wang Mark Meloche C. Bruce Verchere Dawei Ou Alice Mui Garth L. Warnock |
| author_sort | Xiaojie Wang |
| collection | DOAJ |
| description | Islet cell transplantation is currently the only feasible long-term treatment option for patients with type 1 diabetes. However, the majority of transplanted islets experience damage and apoptosis during the isolation process, a blood-mediated inflammatory microenvironment in the portal vein upon islet infusion, hypoxia induced by the low oxygenated milieu, and poor-revascularization-mediated lack of nutrients, and impaired hormone modulation in the local transplanted site. Strategies using genetic modification methods through overexpression or silencing of those proteins involved in promoting new formation of blood vessels or inhibition of apoptosis may overcome these hurdles and improve islet engraftment outcomes. |
| format | Article |
| id | doaj-art-0c564eb16631439eb2a89757c97e1658 |
| institution | Kabale University |
| issn | 2090-0007 2090-0015 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Transplantation |
| spelling | doaj-art-0c564eb16631439eb2a89757c97e16582025-08-20T03:54:19ZengWileyJournal of Transplantation2090-00072090-00152011-01-01201110.1155/2011/594851594851Improving Islet Engraftment by Gene TherapyXiaojie Wang0Mark Meloche1C. Bruce Verchere2Dawei Ou3Alice Mui4Garth L. Warnock5Department of Surgery, University of British Columbia, Vancouver, BC, V5Z 4E3, CanadaDepartment of Surgery, University of British Columbia, Vancouver, BC, V5Z 4E3, CanadaDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, V5Z 4H4, CanadaDepartment of Surgery, University of British Columbia, Vancouver, BC, V5Z 4E3, CanadaDepartment of Surgery, University of British Columbia, Vancouver, BC, V5Z 4E3, CanadaDepartment of Surgery, University of British Columbia, Vancouver, BC, V5Z 4E3, CanadaIslet cell transplantation is currently the only feasible long-term treatment option for patients with type 1 diabetes. However, the majority of transplanted islets experience damage and apoptosis during the isolation process, a blood-mediated inflammatory microenvironment in the portal vein upon islet infusion, hypoxia induced by the low oxygenated milieu, and poor-revascularization-mediated lack of nutrients, and impaired hormone modulation in the local transplanted site. Strategies using genetic modification methods through overexpression or silencing of those proteins involved in promoting new formation of blood vessels or inhibition of apoptosis may overcome these hurdles and improve islet engraftment outcomes.http://dx.doi.org/10.1155/2011/594851 |
| spellingShingle | Xiaojie Wang Mark Meloche C. Bruce Verchere Dawei Ou Alice Mui Garth L. Warnock Improving Islet Engraftment by Gene Therapy Journal of Transplantation |
| title | Improving Islet Engraftment by Gene Therapy |
| title_full | Improving Islet Engraftment by Gene Therapy |
| title_fullStr | Improving Islet Engraftment by Gene Therapy |
| title_full_unstemmed | Improving Islet Engraftment by Gene Therapy |
| title_short | Improving Islet Engraftment by Gene Therapy |
| title_sort | improving islet engraftment by gene therapy |
| url | http://dx.doi.org/10.1155/2011/594851 |
| work_keys_str_mv | AT xiaojiewang improvingisletengraftmentbygenetherapy AT markmeloche improvingisletengraftmentbygenetherapy AT cbruceverchere improvingisletengraftmentbygenetherapy AT daweiou improvingisletengraftmentbygenetherapy AT alicemui improvingisletengraftmentbygenetherapy AT garthlwarnock improvingisletengraftmentbygenetherapy |