Vitamin E for intraventricular hemorrhage prevention in preterm neonates: A systematic review and meta‐analysis
Abstract Background Some research suggests that vitamin E may help prevent intraventricular hemorrhage (IVH) in preterm neonates. However, consolidated evidence regarding its effects on brain vascular health in this population is lacking. This study systematically reviews primary research on this to...
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| Format: | Article |
| Language: | English |
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Wiley
2025-06-01
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| Series: | Neuroprotection |
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| Online Access: | https://doi.org/10.1002/nep3.70005 |
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| author | Felipe Araujo Gouhie Ana Clara Nogueira Cezar Davi Alves Silva Beatriz Rizzo Parreira Larissa Ferreira Machado Laura Caroline Felipe deFreitas Paulo Roberto daSilva Lucena Patriota |
| author_facet | Felipe Araujo Gouhie Ana Clara Nogueira Cezar Davi Alves Silva Beatriz Rizzo Parreira Larissa Ferreira Machado Laura Caroline Felipe deFreitas Paulo Roberto daSilva Lucena Patriota |
| author_sort | Felipe Araujo Gouhie |
| collection | DOAJ |
| description | Abstract Background Some research suggests that vitamin E may help prevent intraventricular hemorrhage (IVH) in preterm neonates. However, consolidated evidence regarding its effects on brain vascular health in this population is lacking. This study systematically reviews primary research on this topic. This study examines the effectiveness of vitamin E supplementation in preventing IVH in preterm neonates than a placebo, thus addressing gaps in the literature. Methods The Cochrane, Dimensions, Embase, and PubMed databases were searched for relevant studies based on specific inclusion criteria. Subsequently, the relevant data were extracted, and statistical analysis was conducted using R studio (version 4.3.1) by applying appropriate models to account for heterogeneity and generate a combined estimate. The results were interpreted considering potential biases and limitations. Results Five studies involving 554 patients were included. Among them, 274 (49.45%) received vitamin E. The results (relative ratio 0.57; 95% confidence interval 0.35–0.92; p = 0.02; I2 = 56%) demonstrated a reduction in the incidence of IVH in patients who received administration of vitamin E (n = 274) compared with those who received a placebo (n = 280). Conclusion These findings highlight the potential therapeutic benefits of vitamin E supplementation in preterm neonates, which show a significant reduction in IVH incidence than placebo. Further research and clinical trials are required to fully explore its protective effects in this population. |
| format | Article |
| id | doaj-art-0c5332747114481ca4aa74a22bef2ec6 |
| institution | Kabale University |
| issn | 2770-7296 2770-730X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neuroprotection |
| spelling | doaj-art-0c5332747114481ca4aa74a22bef2ec62025-08-20T03:27:47ZengWileyNeuroprotection2770-72962770-730X2025-06-013216517110.1002/nep3.70005Vitamin E for intraventricular hemorrhage prevention in preterm neonates: A systematic review and meta‐analysisFelipe Araujo Gouhie0Ana Clara Nogueira Cezar1Davi Alves Silva2Beatriz Rizzo Parreira3Larissa Ferreira Machado4Laura Caroline Felipe deFreitas5Paulo Roberto daSilva Lucena Patriota6Faculty of Medicine Federal University of Uberlândia Uberlândia Minas Gerais BrazilFaculty of Medicine Federal University of Uberlândia Uberlândia Minas Gerais BrazilFaculty of Medicine Federal University of Uberlândia Uberlândia Minas Gerais BrazilFaculty of Medicine Federal University of Uberlândia Uberlândia Minas Gerais BrazilFaculty of Medicine Federal University of Uberlândia Uberlândia Minas Gerais BrazilFaculty of Medicine Federal University of Uberlândia Uberlândia Minas Gerais BrazilFaculty of Medicine Federal University of Uberlândia Uberlândia Minas Gerais BrazilAbstract Background Some research suggests that vitamin E may help prevent intraventricular hemorrhage (IVH) in preterm neonates. However, consolidated evidence regarding its effects on brain vascular health in this population is lacking. This study systematically reviews primary research on this topic. This study examines the effectiveness of vitamin E supplementation in preventing IVH in preterm neonates than a placebo, thus addressing gaps in the literature. Methods The Cochrane, Dimensions, Embase, and PubMed databases were searched for relevant studies based on specific inclusion criteria. Subsequently, the relevant data were extracted, and statistical analysis was conducted using R studio (version 4.3.1) by applying appropriate models to account for heterogeneity and generate a combined estimate. The results were interpreted considering potential biases and limitations. Results Five studies involving 554 patients were included. Among them, 274 (49.45%) received vitamin E. The results (relative ratio 0.57; 95% confidence interval 0.35–0.92; p = 0.02; I2 = 56%) demonstrated a reduction in the incidence of IVH in patients who received administration of vitamin E (n = 274) compared with those who received a placebo (n = 280). Conclusion These findings highlight the potential therapeutic benefits of vitamin E supplementation in preterm neonates, which show a significant reduction in IVH incidence than placebo. Further research and clinical trials are required to fully explore its protective effects in this population.https://doi.org/10.1002/nep3.70005brain vascularintraventricular hemorrhagenewbornpreterm neonatesvitamin E |
| spellingShingle | Felipe Araujo Gouhie Ana Clara Nogueira Cezar Davi Alves Silva Beatriz Rizzo Parreira Larissa Ferreira Machado Laura Caroline Felipe deFreitas Paulo Roberto daSilva Lucena Patriota Vitamin E for intraventricular hemorrhage prevention in preterm neonates: A systematic review and meta‐analysis Neuroprotection brain vascular intraventricular hemorrhage newborn preterm neonates vitamin E |
| title | Vitamin E for intraventricular hemorrhage prevention in preterm neonates: A systematic review and meta‐analysis |
| title_full | Vitamin E for intraventricular hemorrhage prevention in preterm neonates: A systematic review and meta‐analysis |
| title_fullStr | Vitamin E for intraventricular hemorrhage prevention in preterm neonates: A systematic review and meta‐analysis |
| title_full_unstemmed | Vitamin E for intraventricular hemorrhage prevention in preterm neonates: A systematic review and meta‐analysis |
| title_short | Vitamin E for intraventricular hemorrhage prevention in preterm neonates: A systematic review and meta‐analysis |
| title_sort | vitamin e for intraventricular hemorrhage prevention in preterm neonates a systematic review and meta analysis |
| topic | brain vascular intraventricular hemorrhage newborn preterm neonates vitamin E |
| url | https://doi.org/10.1002/nep3.70005 |
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