Dependence receptors: new targets for cancer therapy
Abstract Dependence receptors are known to promote survival and positive signaling such as proliferation, migration, and differentiation when activated, but to actively trigger apoptosis when unbound to their ligand. Their abnormal regulation was shown to be an important feature of tumorigenesis, al...
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| Format: | Article |
| Language: | English |
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Springer Nature
2021-09-01
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| Series: | EMBO Molecular Medicine |
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| Online Access: | https://doi.org/10.15252/emmm.202114495 |
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| _version_ | 1849343562507878400 |
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| author | Morgan Brisset Mélodie Grandin Agnès Bernet Patrick Mehlen Frédéric Hollande |
| author_facet | Morgan Brisset Mélodie Grandin Agnès Bernet Patrick Mehlen Frédéric Hollande |
| author_sort | Morgan Brisset |
| collection | DOAJ |
| description | Abstract Dependence receptors are known to promote survival and positive signaling such as proliferation, migration, and differentiation when activated, but to actively trigger apoptosis when unbound to their ligand. Their abnormal regulation was shown to be an important feature of tumorigenesis, allowing cancer cells to escape apoptosis triggered by these receptors while promoting in parallel major aspects of tumorigenesis such as proliferation, angiogenesis, invasiveness, and chemoresistance. This involvement in multiple cancer hallmarks has raised interest in dependence receptors as targets for cancer therapy. Although additional studies remain necessary to fully understand the complexity of signaling pathways activated by these receptors and to target them efficiently, it is now clear that dependence receptors represent very exciting targets for future cancer treatment. This manuscript reviews current knowledge on the contribution of dependence receptors to cancer and highlights the potential for therapies that activate pro‐apoptotic functions of these proteins. |
| format | Article |
| id | doaj-art-0c4f0d08899a4d80b0e26d0f7659852a |
| institution | Kabale University |
| issn | 1757-4676 1757-4684 |
| language | English |
| publishDate | 2021-09-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | EMBO Molecular Medicine |
| spelling | doaj-art-0c4f0d08899a4d80b0e26d0f7659852a2025-08-20T03:42:56ZengSpringer NatureEMBO Molecular Medicine1757-46761757-46842021-09-01131111410.15252/emmm.202114495Dependence receptors: new targets for cancer therapyMorgan Brisset0Mélodie Grandin1Agnès Bernet2Patrick Mehlen3Frédéric Hollande4Department of Clinical Pathology, Victorian Comprehensive Cancer Centre, The University of MelbourneDepartment of Clinical Pathology, Victorian Comprehensive Cancer Centre, The University of MelbourneApoptosis, Cancer and Development Laboratory, Centre de Recherche en Cancérologie de Lyon, INSERM U1052‐CNRS UMR5286, Centre Léon Bérard, Université de LyonApoptosis, Cancer and Development Laboratory, Centre de Recherche en Cancérologie de Lyon, INSERM U1052‐CNRS UMR5286, Centre Léon Bérard, Université de LyonDepartment of Clinical Pathology, Victorian Comprehensive Cancer Centre, The University of MelbourneAbstract Dependence receptors are known to promote survival and positive signaling such as proliferation, migration, and differentiation when activated, but to actively trigger apoptosis when unbound to their ligand. Their abnormal regulation was shown to be an important feature of tumorigenesis, allowing cancer cells to escape apoptosis triggered by these receptors while promoting in parallel major aspects of tumorigenesis such as proliferation, angiogenesis, invasiveness, and chemoresistance. This involvement in multiple cancer hallmarks has raised interest in dependence receptors as targets for cancer therapy. Although additional studies remain necessary to fully understand the complexity of signaling pathways activated by these receptors and to target them efficiently, it is now clear that dependence receptors represent very exciting targets for future cancer treatment. This manuscript reviews current knowledge on the contribution of dependence receptors to cancer and highlights the potential for therapies that activate pro‐apoptotic functions of these proteins.https://doi.org/10.15252/emmm.202114495apoptosiscancer hallmarkstreatment resistancetumor progression |
| spellingShingle | Morgan Brisset Mélodie Grandin Agnès Bernet Patrick Mehlen Frédéric Hollande Dependence receptors: new targets for cancer therapy EMBO Molecular Medicine apoptosis cancer hallmarks treatment resistance tumor progression |
| title | Dependence receptors: new targets for cancer therapy |
| title_full | Dependence receptors: new targets for cancer therapy |
| title_fullStr | Dependence receptors: new targets for cancer therapy |
| title_full_unstemmed | Dependence receptors: new targets for cancer therapy |
| title_short | Dependence receptors: new targets for cancer therapy |
| title_sort | dependence receptors new targets for cancer therapy |
| topic | apoptosis cancer hallmarks treatment resistance tumor progression |
| url | https://doi.org/10.15252/emmm.202114495 |
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